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Medicine for treating diastolic cardiac insufficiency and preparation method of medicine

A technique for cardiac insufficiency and relaxation, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients. It can solve problems such as increased ventricular filling pressure and poor compliance of ventricular wall motion, achieving good stability The effect of high bioavailability

Inactive Publication Date: 2016-06-22
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Diastolic heart failure (diastolic heart failure, DHF) refers to the normal or slightly reduced ventricular systolic function, the reduction of ventricular muscle relaxation and compliance, the reduction of ventricular filling and the increase of filling pressure, resulting in pulmonary and systemic circulation congestion. A clinical syndrome in which a patient has clinical symptoms of heart failure but a normal ejection fraction and the heart has thickened walls and poor wall motion compliance

Method used

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  • Medicine for treating diastolic cardiac insufficiency and preparation method of medicine
  • Medicine for treating diastolic cardiac insufficiency and preparation method of medicine
  • Medicine for treating diastolic cardiac insufficiency and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 metoprolol liposome:

[0026] 1) Dissolve 50g of metoprolol, 100g of cholesterol, 20g of soybean lecithin, 80g of distearoylphosphatidylethanolamine-polyethylene glycol, 5g of propyl gallate and 20g of spar in an appropriate amount of ethanol, mix well, Filtrate, remove ethanol by evaporation to obtain a phospholipid film, and dry; 2) add a phosphate buffer solution with a pH value of 7.0 to completely hydrate the phospholipid film, then homogeneously emulsify with a tissue grinder, mix the solution evenly, and ultrasonically treat for 60 minutes to prepare Obtain liposome suspension; 3) spray-dry the suspension obtained in step 2) to obtain metoprolol liposome powder.

Embodiment 2

[0027] The preparation of embodiment 2 metoprolol liposomes:

[0028] 1) Dissolve 50g of metoprolol, 80g of cholesterol, 30g of soybean lecithin, 60g of distearoylphosphatidylethanolamine-polyethylene glycol, 10g of propyl gallate and 10g of spar in an appropriate amount of ethanol, mix well, Filtrate, remove ethanol by evaporation to obtain a phospholipid film, and dry; 2) add a phosphate buffer solution with a pH value of 6.5 to completely hydrate the phospholipid film, then use a tissue masher to homogeneously emulsify, mix the solution evenly, and ultrasonically treat for 60 minutes to prepare Obtain liposome suspension; 3) spray-dry the suspension obtained in step 2) to prepare metoprolol liposome powder.

Embodiment 3

[0029] Embodiment 3 The preparation of the medicine for the treatment of diastolic cardiac insufficiency

[0030]

[0031]

[0032] Preparation Process:

[0033]1) get the metoprolol liposome, hydrochlorothiazide, spironolactone prepared by the embodiment 1 of prescription quantity, and various adjuvants for subsequent use; , carboxymethylcellulose calcium, sucrose stearate, sodium lauryl sulfate, and stevioside are mixed evenly, and an appropriate amount of ethanol is added to make a soft material, granulated with a 20-mesh sieve and dried, granulated with a 20-mesh sieve, added The magnesium stearate is mixed evenly, the weight of the tablet is controlled, and the tablet is compressed.

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Abstract

The invention relates to a medicine for treating diastolic cardiac insufficiency and a preparation method of the medicine. The medicine contains metoprolol lipidosome, hydrochlorothiazide, spirolactone, filler, a disintegrating agent and a surfactant, wherein metoprolol lipidsome comprises metoprolol, cholesterol, soybean lecithin, (distearoyl-phosphatidylethanolamine)-polyethylene glycol, propylgallate and Span. The medicine has the advantages that the accumulative dissolutive degree is high, the medicine is slowly and constantly released, the biological utilization rate is high, the stability is good, the medicine has a remarkable treatment effect on diastolic cardiac insufficiency, a preparation process is simple and suitable for industrial production and the like.

Description

technical field [0001] The invention belongs to the field of western medicine preparations, and relates to a medicine for treating diastolic cardiac insufficiency and a preparation method thereof, in particular to a medicine for treating diastolic cardiac insufficiency containing metoprolol liposome, hydrochlorothiazide and spironolactone . Background technique [0002] Diastolic heart failure (DHF) refers to the decrease of ventricular muscle relaxation and compliance in the case of normal or slightly reduced ventricular systolic function, resulting in reduced ventricular filling and increased filling pressure, resulting in congestion in the pulmonary and systemic circulation. A group of clinical syndromes in which patients have clinical symptoms of heart failure but a normal ejection fraction and the heart has thickened walls and poor wall motion compliance. From the perspective of pathophysiology, diastolic heart failure is a compensatory state in which the left ventricl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/127A61K31/585A61P9/00A61K31/138A61K31/549
CPCA61K9/127A61K9/2059A61K31/138A61K31/549A61K31/585A61K2300/00
Inventor 董春红刘麒赵琳
Owner QINGDAO CENT HOSPITAL
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