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Medicinal composition containing fenofibric acid

A fenofibric acid and composition technology, which is applied in the field of medicine, can solve the problems of long processing time, difficult dosage control and high related substances, and achieves the effects of good stability, simple and easy production operation and complete dissolution.

Active Publication Date: 2016-05-18
长春海悦药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the micropellet process requires fluidized bed bottom spray coating technology, multiple coatings on the micropellets, long processing time, the prepared suspension is not conducive to patients taking, and the dosage is not easy to control
[0007] None of the above information mentions fenofibric acid and its physiologically acceptable salt common tablet and its preparation method
Although the dissolution rate can be improved by using wet granulation process, the related substances are relatively high

Method used

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  • Medicinal composition containing fenofibric acid
  • Medicinal composition containing fenofibric acid
  • Medicinal composition containing fenofibric acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] prescription

[0072] Fenofibric acid 1.0g

[0073] Methylcellulose 7.2g

[0074] Erythritol 3.6g

[0075] Starch 35g

[0076] Micropowder silica gel 1.8g.

[0077] Preparation method: sieve fenofibric acid, methylcellulose, erythritol, starch, and micropowdered silica gel respectively, mix, sieve, mix evenly, and press into tablets to obtain fenofibric acid tablets.

Embodiment 2

[0079] prescription

[0080] Fenofibric acid 1.5g

[0081] Methylcellulose 4.5g

[0082] Erythritol 2.0g

[0083] Lactose 38g

[0084] Talc powder 2.8g.

[0085] Preparation method: sieve fenofibric acid, methylcellulose, erythritol, lactose, and talcum powder respectively, mix evenly, sieve, mix evenly, and press into tablets to obtain fenofibric acid tablets.

Embodiment 3

[0087] prescription

[0088] Fenofibric acid 2.0g

[0089] Methylcellulose 6.2g

[0090] Erythritol 2.8g

[0091] 45g powdered sugar

[0092] Micropowder silica gel 2.5g.

[0093] Preparation method: sieve and mix fenofibric acid, methylcellulose, erythritol, powdered sugar, and micronized silica gel respectively, pass through a 20-mesh sieve, mix for 20 minutes, and press into tablets to obtain fenofibric acid tablets .

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a medicinal composition containing fenofibric acid. The medicinal composition contains the fenofibric acid, a filling agent, a disintegrating agent, a lubricating agent, methylcellulose and mannitol granules. The medicinal composition is good in stability, dissolves out completely, and has excellent quality; the production of the medicinal composition is simple and feasible to operate, and the medicinal composition is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing fenofibric acid and a preparation method of tablets thereof. Background technique [0002] Fenofibric acid (English name FenofibricAcid), its chemical name is: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid. Molecular formula: C 17 h 15 ClO 4 , molecular weight: 318.75, its structural formula is as follows: [0003] [0004] Fenofibric acid is a second-generation phenoxyaromatic acid drug used to treat hypercholesterolemia and hypertriglyceridemia. It is the metabolite and active ingredient of fenofibrate in the human body. Therefore, it has better bioavailability than fenofibrate, and the bioavailability is not affected by food. [0005] Chinese patent CN102172347A discloses a preparation process of fenofibric acid enteric-coated sustained-release capsules. By granulating and pressing tablets to form microtable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/216A61K47/38A61K47/26A61P3/06
Inventor 郝昕袁春玲韩翠娟
Owner 长春海悦药业股份有限公司
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