Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of strontium, iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method

A technology of hydroxyapatite and collagen fibers, which is applied in the fields of iron compounds, chemical instruments and methods, medical science, etc., to achieve the effects of repairing and treating bone defects, improving mechanical strength, and good biological activity

Active Publication Date: 2018-06-12
SHANGHAI NAT ENG RES CENT FORNANOTECH
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiency of single bone repair material performance, and introduce certain functional particle, provide a kind of strontium, iron doped hydroxyapatite / collagen fiber composite support material and preparation method, to obtain a kind of having excellent Composite scaffold materials for bone repair with biological properties, mechanical properties, and certain drug therapy functions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of strontium, iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 4gSr(NO 3 ) 2 , 61gFeCl 3 ·6H 2 O, added to 200mL deionized water, added to deionized water, magnetically stirred to dissolve; after it was completely dissolved, added to 250mL 60% sodium carbonate solution, controlled temperature at 35°C, stirred to make it co-precipitate, and then ultrasonicated for 10 min, vacuum filtration, and then put the filter cake in a blast drying oven, and dry at 90°C for 24 hours to obtain a precursor powder; weigh 1.0g NaCl and mix it with the precursor powder, grind it evenly and place it in a muffle furnace, The speed of ℃ / min is raised to 900 ℃, and calcined for 6 hours to obtain SrFe 12 o 19 powder.

[0031] (2) Weigh 5.54g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 Powder, stir evenly at room temperature; weigh 3.95g ammonium hydrogen phosphate and add it to...

Embodiment 2

[0035] (1) The same as described in Example 1.

[0036] (2) Weigh 11.08g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 Powder, stir evenly at room temperature; weigh 7.91g of ammonium hydrogen phosphate and add it to deionized water to dissolve, adjust the pH of the solution to 10 with ammonia water, slowly add it to the above mixed solution containing calcium chloride at room temperature, continue to stir for 1 hour, and let it stand for 12 hours , then washed with deionized water and ethanol, dried at 80°C for 24 hours to obtain strontium and iron doped hydroxyapatite, and ball milled the prepared strontium and iron doped hydroxyapatite at a speed of 300 r / min for 10 hours, and set aside .

[0037] (3) The same as described in Example 1.

Embodiment 3

[0039] (1) The same as described in Example 1.

[0040] (2) Weigh 16.61g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 Powder, stir evenly at room temperature; weigh 11.86g of ammonium hydrogen phosphate and add it to deionized water to dissolve, adjust the pH of the solution to 10 with ammonia water, slowly add it to the above mixed solution containing calcium chloride at room temperature, continue stirring for 1 hour, and let it stand for 12 hours , then washed with deionized water and ethanol, dried at 80°C for 24 hours to obtain strontium and iron doped hydroxyapatite, and ball milled the prepared strontium and iron doped hydroxyapatite at a speed of 300 r / min for 10 hours, and set aside .

[0041] (3) The same as described in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and a preparation method thereof. The scaffold material is prepared through compounding collagen fibers having a three dimensional connective porous structure with strontium and iron doped hydroxyapatite with a good drug therapy function. The preparation method mainly comprises the following steps: preparing strontium and iron doped hydroxyapatite through a co-precipitation technology; and compounding the collagen fibers through a dipping-pulling technology. The functional bone restoration scaffold material has excellent biologic performances, very good mechanical strength and toughness and a three dimensional connective macro-porous structure, can deliver drugs to a specific position under the induction of a magnetic field, can restore and treat bone defects induced by various bone diseases, and has wide application prospect in the field of bone restoration materials and biological drugs.

Description

technical field [0001] The invention relates to the field of artificial bone repair materials and biomedicine, in particular to a strontium and iron doped hydroxyapatite / collagen fiber composite scaffold material and a preparation method thereof. Background technique [0002] With the continuous development of biomedicine, the repair of bone defects caused by various diseases and traumas has attracted widespread attention. Due to the limited sources of natural bone and autologous bone, the development of new artificial bone repair materials has an important theory significance and application value. [0003] Hydroxyapatite is the main inorganic component of human bones and teeth. Because of its good biocompatibility and osteoinductive ability, it can form a tight chemical bond with human bone tissue at the interface after implanted in the human body, thereby inducing bone formation. The growth of tissue promotes bone repair, and it is a good hard tissue replacement material...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/54A61L27/56A61L27/58C01G49/00
Inventor 何丹农阳俊周涓张彬金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com