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Albendazole ivermectin rumen floating tablets used for cud chewer and preparation method of albendazole ivermectin rumen floating tablets

A technology of albendazole and albendazole is applied in the field of albendazole ivermectin rumen floating tablet and its preparation, which can solve the problems of repeated administration, inconvenience and the like, and reduce the number of times of medication , Increase the stability, the effect of long floating time

Active Publication Date: 2016-02-24
LONGCHANG RUIZHI HENGCHUANG BIOLOGICAL TECHCO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently used products are mainly albendazole ivermectin powder and albendazole ivermectin tablet. The biggest problem is that repeated administration is required, and it usually takes 7 days of continuous administration to achieve the desired result. The insect repellent effect brings great inconvenience to the use of this type of product

Method used

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  • Albendazole ivermectin rumen floating tablets used for cud chewer and preparation method of albendazole ivermectin rumen floating tablets
  • Albendazole ivermectin rumen floating tablets used for cud chewer and preparation method of albendazole ivermectin rumen floating tablets
  • Albendazole ivermectin rumen floating tablets used for cud chewer and preparation method of albendazole ivermectin rumen floating tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of albendazol ivermectin rumen floating tablet, it comprises following components, and each component is by the weight of 1000 used amounts:

[0032]

[0033]

[0034] The foaming material is a sodium bicarbonate-citric acid composition, and its weight ratio is 1:0.7.

[0035] The preparation method of albendazole ivermectin rumen floating tablet comprises the following steps:

[0036] (1), HPMCK100M, sodium bicarbonate, citric acid, albendazole, and ivermectin were pulverized respectively, and passed through an 80-mesh sieve for subsequent use;

[0037] (2), take the glyceryl monostearate of recipe quantity, heat to 70-80 ℃, wait for it to melt into liquid state, keep 5-10 minute;

[0038] (3), add the prescribed amount of albendazole and ivermectin to the liquid obtained in step (2), keep the temperature at 70-80°C, and stir until the albendazole and ivermectin are completely distributed evenly;

[0039] (4), the suspension obtained in step (3) is evenl...

Embodiment 2

[0042] A kind of albendazol ivermectin rumen floating tablet, it comprises following components, and the parts by weight of each component are by 1000 used amounts:

[0043]

[0044] The foaming material is a sodium bicarbonate-citric acid composition, and its weight ratio is 1:0.7.

[0045] The preparation method of albendazole ivermectin rumen floating tablet comprises the following steps:

[0046] (1), HPMCK100M, sodium bicarbonate, citric acid, albendazole, and ivermectin were pulverized respectively, and passed through an 80-mesh sieve for subsequent use;

[0047] (2), take the glyceryl monostearate of recipe quantity, heat to 70-80 ℃, wait for it to melt into liquid state, keep 5-10 minute;

[0048] (3), add the prescribed amount of albendazole and ivermectin to the liquid obtained in step (2), keep the temperature at 70-80°C, and stir until the albendazole and ivermectin are completely distributed evenly;

[0049] (4), the suspension obtained in step (3) is evenly ...

Embodiment 3

[0052] A kind of albendazol ivermectin rumen floating tablet, it comprises following components, and the parts by weight of each component are by 1000 used amounts:

[0053]

[0054] The foaming material is a sodium bicarbonate-citric acid composition, and its weight ratio is 1:0.7.

[0055] The preparation method of albendazole ivermectin rumen floating tablet comprises the following steps:

[0056] (1), HPMCK100M, sodium bicarbonate, citric acid, albendazole, and ivermectin were pulverized respectively, and passed through an 80-mesh sieve for subsequent use;

[0057] (2), take the glyceryl monostearate of recipe quantity, heat to 70-80 ℃, wait for it to melt into liquid state, keep 5-10 minute;

[0058] (3), add the prescribed amount of albendazole and ivermectin to the liquid obtained in step (2), keep the temperature at 70-80°C, and stir until the albendazole and ivermectin are completely distributed evenly;

[0059](4), the suspension obtained in step (3) is evenly s...

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Abstract

The invention belongs to the field of veterinary drugs and relates to the technical field of animal pharmaceutical manufacturing, in particular to albendazole ivermectin rumen floating tablets used for a cud chewer and a preparation method of the albendazole ivermectin rumen floating tablets. The albendazole ivermectin rumen floating tablets are prepared from, by weight, 10-50 parts of albendazole, 0.02-0.2 part of ivermectin, 10-50 parts of water-based gel materials, 10-60 parts of slow-release material and floating-assisted materials and 5-30 parts of foaming materials. The prepared albendazole ivermectin rumen floating tablets are short in blenching time, continuous floating time is 20 hours or more, blood drug concentration peak valley fluctuation of a product is small, and the medicine taking times can be reduced.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, relates to the technical field of animal medicine manufacture, and specifically relates to an albendazole ivermectin rumen floating tablet for ruminants and a preparation method thereof. Background technique [0002] Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. It has a wide anthelmintic spectrum and the strongest insecticidal effect among benzimidazoles. The mechanism of action is that after albendazole is metabolized into sulfoxides or sulfones in the body, it inhibits the absorption of glucose by the parasite, leading to the depletion of glycogen in the parasite, or inhibits the fumarate reductase system, hinders the production of ATP, and makes the parasite unable to absorb glucose. survive and reproduce. It is highly active against nematodes, schistosomes, and tapeworms, and has a significant inhibitory effect on the development of eggs. Suitable fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/14A61K31/7048A61P33/00A61K31/4184
CPCA61K9/0068A61K9/2013A61K31/4184A61K31/7048A61K2300/00
Inventor 张槐陶勇张纯林陈强黄玉伟黄声全卢朝华张德萍
Owner LONGCHANG RUIZHI HENGCHUANG BIOLOGICAL TECHCO LTD
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