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Processing process for salinomycin granular preparation

A technology of granule preparation and processing technology, which is applied in the field of medicine, can solve problems such as low yield and unsatisfactory spray effect, and achieve the effects of overcoming low yield, shortening the time of stratification, and improving efficiency

Inactive Publication Date: 2016-02-17
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide the processing technology of salinomycin granule preparation, to overcome the problems of low yield and unsatisfactory spray effect caused by the existing salinomycin granule preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The processing technology of salinomycin granule preparation comprises the following steps:

[0024] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 80,000u / ml to 4.0 with sulfuric acid;

[0025] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 60°C for 3 hours;

[0026] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 8.5, full saponification;

[0027] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation 10% of the liquid mass;

[0028] 5) S...

Embodiment 2

[0032] The processing technology of salinomycin granule preparation comprises the following steps:

[0033] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 90000u / ml to 4.5 with sulfuric acid;

[0034] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 62°C for 3.5 hours;

[0035] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.0, fully saponified;

[0036] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation 15% of the liquid mass;

[0037] 5) Spr...

Embodiment 3

[0041] The processing technology of salinomycin granule preparation comprises the following steps:

[0042] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 100,000u / ml to 5.0 with sulfuric acid;

[0043] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 65°C for 4 hours;

[0044] 3) Plate and frame filtration: Add sodium hydroxide as a saponification agent to the acidic fermentation broth obtained in step 2), add perlite, diatomaceous earth and light calcium carbonate as filter aids, and add sodium carbonate to adjust the pH to 9.5, full saponification;

[0045] 4) Preparation of salinomycin feed liquid: add a certain amount of light calcium carbonate to the fermentation liquid obtained after saponification in step 3) to make salinomycin feed liquid, the amount of light calcium carbonate added is for acidic fermentation 20% of the liquid mass;

[0046] 5) ...

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Abstract

The invention relates to a processing process for a salinomycin granular preparation. The processing process includes the following steps that acid fermentation liquor is prepared; the pH value of the salinomycin fermentation liquor is adjusted to range from 4.0 to 5.0 through acid liquor; the acid fermentation liquor is pre-treated, wherein the acid fermentation liquor with the adjusted pH value is subjected to heat preservation for 3-4 hours at the temperature of 60 DEG C to 65 DEG C; the pH value is adjusted into an alkaline state for saponification, and salinomycin feed liquor is prepared, wherein a certain amount of light calcium carbonate is added to the obtained acid fermentation liquor to prepare the salinomycin feed liquor; spray drying is conducted, wherein after spraying particles are added to the prepared salinomycin feed liquor, the salinomycin feed liquor is prepared into particles through a spray drying method, the particles are screened, the particles and auxiliary materials are packaged in a mixed mode, and then the salinomycin granular preparation is obtained. The problems of the low yield and the unideal spraying effect caused by an existing salinomycin granular preparation process are solved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the processing technology of salinomycin granule preparation. Background technique [0002] Salinomycin is a polyether ionophore antibiotic produced by Streptomyces albus. Salinomycin granule preparation not only has good antibacterial effect, low toxicity and low residue, simple production process, readily available raw materials and low price, it is one of the most promising veterinary drugs recognized in the market. [0003] Salinomycin has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidiosis, and it is not easy to produce drug resistance and cross-resistance. It is excreted quickly and the residual amount is extremely low. It can be used to prevent diarrhea, Promote production and increase survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, and rubidium ions, but these ion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7048A61P31/04
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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