Anti-hypertension urapidil medicine compound

Abstract

The invention discloses an anti-hypertension urapidil medicine compound, and belongs to the technical field of medicine. X-ray powder diffraction patterns of the anti-hypertension urapidil medicine compound measured by Cu-Ka rays are shown as a figure 1. Compared with the prior art, the anti-hypertension urapidil medicine compound has the advantages that the anti-hypertension urapidil medicine compound which is a urapidil crystal-form compound is good in stability and rarely contains impurities I, and the total impurity content of the anti-hypertension urapidil medicine compound is within a narrow range under the control and rarely changes along with extension of the storage time; the solubility and the flowability of the urapidil crystal-form compound in water are obviously improved, accordingly, the anti-hypertension urapidil medicine compound brings convenience for preparing preparations, and the efficacy of the anti-hypertension urapidil medicine compound can be greatly improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antihypertensive drug urapidil compound. Background technique [0002] Hypertension is a kind of common disease, frequently-occurring disease. With the improvement of people's living standards, the number of hypertensive patients is increasing day by day, especially the number of hypertensive crisis and severe hypertensive patients is constantly increasing, but there are few safe and effective injection drugs clinically used for this type of disease. High blood pressure affects work and life, and high blood pressure is the most important risk factor for coronary heart disease and cerebrovascular disease. 50% of myocardial infarction patients are hypertensive patients, and 76% of stroke patients have a history of hypertension. Therefore, the risk of high blood pressure is sudden death or disability. Hypertensive patients should learn how to take care of life and early treat...

AI Technical Summary

Problems solved by technology

However, because urapidil hydrochloride is easily soluble in water and slightly soluble in organic solvents (such as ethanol), urapidil hydrochloride is not easy to be refined by general purification processes such as recrystallization, and the quality of urapidil hydrochloride after refining It cannot meet the requirements of the Chinese National Drug Standard WS-(X-116)-2003Z, especially the clarity>No. 2 standard turbidity liquid, and the quality cannot meet the purity requirements of injection drugs. Therefore, the purification of urapidil is particularly important

[0006] Urapidil in the prior art has disadvantages such as poor stability, easy decomposition and deterioration, and difficult storage under special circumstances (such as high temperature and light), which are largely limits the wide application of the drug

Find that there is a certain amount of oxidative degradation product I in the urapidil in the prior art through a large number of experimental studies simultaneously, as impurity, it shows the risk that has toxicity to patient or is harmful in other respects, has had a strong impact on the quality of medicine, increases patient risk

The existing technology solves the problems of water solubility and stability by changing the excipients and preparation methods of the preparation. It must rely on specific prescriptions and processes to achieve its stable effect, which brings certain limitations to the preparation of preparations and the selection of excipients. sex

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