Method for measuring eight carbonyl compounds in electronic cigarette tobacco tar
A carbonyl compound and e-cigarette liquid technology, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of affecting the measurement results, restricting applications, and large differences in ratios, and achieves good repeatability, high sensitivity, and fewer impurity peaks Effect
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example 1
[0025] Standard working solutions with different concentrations were injected into HPLC, and the limit of detection (LOD) was calculated with a 3-fold signal-to-noise ratio (S / N = 3), and the detection limit was between 0.029 μg / g and 0.076 μg / g. The spiked recovery experiment was carried out at three concentration levels of low, medium and high, and the experiments were carried out in parallel for 5 times, and the results were averaged (see Table 2). The results showed that the recoveries of eight carbonyl compounds ranged from 91.1% to 102.3%, and the average relative standard deviation (RSD) was less than 6.0%.
[0026] Table 2 Recovery and repeatability of 8 carbonyl compounds (n=5)
[0027] serial number Compound name LOD(μg / g) Recovery rate(%) RSD (%) 1 formaldehyde 0.029 97.5 3.8 2 Acetaldehyde 0.037 91.1 4.5 3 acetone 0.048 100.2 4.3 4 acrolein 0.044 90.3 5.1 5 ...
example 2
[0029] Weigh 0.5 g of e-cigarette liquid, add DNPH derivatization reagent, dilute to 5 mL, shake well, place at room temperature for 30-150 min for derivatization reaction, pass the reaction solution through a 0.45 μm organic phase filter membrane; pipette 0.5 mL for reaction solution, and added 0.5 mL of Tris base, shaken, into the HPLC analysis. The measurement was repeated 5 times, and the relative standard deviation was calculated to obtain the precision of the method.
[0030] Table 3 Method precision
[0031]
[0032] Note: N.D. is not detected.
example 3
[0034] A commercially available mint-flavored e-cigarette liquid was pretreated according to the method described in Example 2 and tested by HPLC. The contents of the eight carbonyl compounds in the e-cigarette liquid sample were: formaldehyde 12.03 μg / g, acetaldehyde 0.03 μg / g, acetone 0.39 μg / g, acrolein 0.78 μg / g, propionaldehyde, crotonaldehyde, 2-butanone and butyraldehyde were not detected.
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