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A tumor-targeted radioactive nanoparticle and its preparation method

A nanoparticle and radioactive technology, applied in the field of radionuclide-labeled nanoparticles and its preparation, can solve the problems of insufficient specificity in the early diagnosis of lung cancer

Active Publication Date: 2018-12-25
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] In order to solve the problem of insufficient specificity in the early diagnosis of lung cancer at present, and realize that it can be used for PET / MRI imaging at the same time, the present invention provides a radioactive nanoparticle targeting lung cancer, including a carrier, a surface modification molecule, a tumor targeting molecule and a radionuclide , characterized by:

Method used

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  • A tumor-targeted radioactive nanoparticle and its preparation method

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Embodiment 1

[0048] Example 1, the preparation method of radioactive nanoparticles targeting lung cancer of the present invention:

[0049] Weigh 353mg of iron acetylacetonate into a three-necked flask, add 144mg of polyacrylic acid solution (mass fraction: 50%), add 30ml of triethylene glycol, heat the mixture to 185°C for 0.5h, and heat it at 10°C / Heat at a heating rate of 3min to 287°C for 0.5h, cool naturally to room temperature, add 50ml of ethyl acetate for flocculation, magnetic separation, remove the supernatant, wash the remaining ethyl acetate and unreacted substances with ethanol, and finally remove the black Iron oxide nanoparticles, dissolved in deionized water, concentrate the iron oxide nanoparticles to 4mg / ml.

[0050] Take 500 μL iron oxide nanoparticle suspension in a 2 mL straight plastic centrifuge tube, add 4 mg propargylamine (structural formula: NH 2 -CH 2 -C≡CH), weigh 8mg EDC, add 100ul water to make EDC solution, weigh 12mg sulfo-NHS, add 100ul water to make su...

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Abstract

The invention discloses lung cancer targeted radioactive nano-particles and a preparation method thereof. The nano-particles comprise iron oxide nano-particles of which the particle size is smaller than or equal to 10 nm, polyacrylic acid, propargyl amine compounds (as shown in specifications ), cyclic peptide (as shown in specifications) containing the sequence of arginine-glycine-aspartic acid-phenylalanine-lysine-azidoacetic acid, small peptide (as shown in specifications) containing the sequence of tyrosine-histidine-tryptophan-tyrosine-glycine-tyrosine-threonine-proline-glutamine-asparaginate-valine-isoleucine-lysine-azidoacetic acid and radioactive nuclides containing fluorine-18(18F). The prepared nano-particles can be used for performing PET / MRI early-stage and specific diagnosis on the lung tumor.

Description

technical field [0001] The invention relates to a novel nanoparticle and a preparation method thereof, in particular to a tumor-targeted, radionuclide-labeled nanoparticle and a preparation method thereof. Background technique [0002] In recent years, new contrast agents have been developed at a rapid rate, and molecular imaging can monitor biological metabolism non-invasively. Traditional imaging techniques include positron emission computed tomography (PET for short), computed tomography (CT for short), magnetic resonance imaging (MRI for short), optical imaging, and ultrasound imaging. Integrating two or more imaging techniques is a hot topic of research. The fusion of PET and CT is an example of application. PET / CT combines the histological information provided by CT with the functional metabolic information provided by PET to achieve better identification and localization results. However, PET / CT also has some shortcomings. Compared with CT, MRI has better soft tissu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K51/12A61K49/08A61K49/18A61K101/02
Inventor 张春富童美魁
Owner SHANGHAI JIAO TONG UNIV
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