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Clean Production Method of Methionine

A production method and technology of methionine, which is applied in the field of clean production technology of methionine, can solve the problems such as the difficulty of separating methionine analog salts, achieve the effects of high purity and yield, clean and environmentally friendly production, and reduce production costs

Active Publication Date: 2017-01-04
NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method solves the problem of difficult separation of methionine, by-produced inorganic salts and by-produced methionine analog salts in the prior art, solves the environmental protection problems of the company's current production of methionine, improves the quality of methionine products, and reduces the production of methionine Discharge of salt-containing and methionine-containing mother liquor in the process, reduce the loss rate of methionine, and reduce the production cost of methionine

Method used

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  • Clean Production Method of Methionine
  • Clean Production Method of Methionine
  • Clean Production Method of Methionine

Examples

Experimental program
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Effect test

Embodiment 1

[0039] At 40°C, introduce 113.3g of 60% ammonia water (4mol) into a 500ml autoclave, then add 1mol of 2-hydroxy-4-methylthiobutyronitrile with a pump within 2 minutes, stirring The temperature was raised to 60° C., and the pressure of the reaction system reached 1.5 MPa. Stirring was continued at this temperature for 40 minutes, then the temperature was immediately cooled to room temperature, and the pressure was reduced to normal pressure. The mixture in the reaction system was analyzed by HPLC, showing that 99.2% of 2-amino-4-methylthiobutyronitrile was formed, and 0.8% of 2,2'-bis-(2-methylthioethyl)iminodiacetonitrile was formed.

[0040] The 2-amino-4-methylthiobutyronitrile aqueous solution obtained above is directly added dropwise in the emulsion of calcium hydroxide (1.5mol), the mass ratio of calcium hydroxide and water in this emulsion is 1:4, and the reaction temperature is 80°C, controlled dropwise for about 2 hours, while stirring to discharge ammonia; fully hydr...

Embodiment 2

[0043] At 40°C, introduce 113.3g of 60% ammonia water (4mol) into a 500ml autoclave, then add 1mol of 2-hydroxy-4-methylthiobutyronitrile with a pump within 2 minutes, stirring The temperature was raised to 60° C., and the pressure of the reaction system reached 1.5 MPa. Stirring was continued at this temperature for 40 minutes, then the temperature was immediately cooled to room temperature, and the pressure was reduced to normal pressure. The mixture in the reaction system was analyzed by HPLC, showing that 99.2% of 2-amino-4-methylthiobutyronitrile was formed, and 0.8% of 2,2'-bis-(2-methylthioethyl)iminodiacetonitrile was formed.

[0044] The 2-amino-4-methylthiobutyronitrile aqueous solution obtained above is directly added dropwise in the emulsion of calcium hydroxide (1.5mol), the mass ratio of calcium hydroxide and water in this emulsion is 1:4, and the reaction temperature is 80°C, controlled dropwise for about 2 hours, while stirring to discharge ammonia; fully hydr...

Embodiment 3

[0048] At 45°C, introduce 85g of 80% ammonia water (4mol) into a 250ml autoclave, then add 1mol of 2-hydroxy-4-methylthiobutyronitrile with a pump within 2 minutes, and heat up while stirring At 60°C, the pressure of the reaction system reaches 2.0 MPa. Stirring was continued at this temperature for 40 minutes, then the temperature was immediately cooled to room temperature, and the pressure was reduced to normal pressure. The mixture in the reaction system was analyzed by HPLC, showing that 99.5% of 2-amino-4-methylthiobutyronitrile was formed, and 0.5% of 2,2'-bis-(2-methylthioethyl)iminodiacetonitrile was formed.

[0049] The 2-amino-4-methylthiobutyronitrile aqueous solution obtained above is directly added in the 1L autoclave that calcium hydroxide (1.5mol) emulsion is housed, and the mass ratio of calcium hydroxide and water in this emulsion is 1: 4. The reaction temperature is 100°C, heat preservation and stirring for about 2 hours, fully hydrolyzed, then release the p...

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Abstract

The present invention belongs to the technical field of organic compound production, separation and purification, and particularly relates to a clean production method of methionine. According to the method, 2-amino-4-methylthiobutyronitrile is subjected to hydrolysis by using calcium hydroxide and / or barium hydroxide to prepare methionine calcium / barium, the calcium / barium salt of the byproduct 2,2'-bis-(2-methylthioethyl)iminodiacetic acid is insoluble in water so as to easily separate and purify the methionine calcium / barium and the insoluble byproduct, then the methionine calcium / barium aqueous solution is neutralized by using carbon dioxide to produce the insoluble calcium carbonate / barium and other insoluble precipitates at a high temperature so as to achieve the methionine separation purpose, and the calcium carbonate / barium salt is subjected to calcination to decompose into the carbon dioxide and the oxides, wherein the carbon dioxide and the oxides can be recycled. Compared with the method in the prior art, the method of the present invention has characteristics of low methionine loss rate, high product purity, simple operation, low cost, no low-value inorganic salt production, no emission of a lot of acidic and odor wastewater, and green environmental protection.

Description

technical field [0001] The invention belongs to the technical field of production, separation and purification of organic compounds, and in particular relates to a clean production process of methionine. Background technique [0002] D, L-methionine, also known as methionine, is one of the basic units of protein and the only amino acid containing sulfur among the essential amino acids. In addition to participating in the transfer of methyl groups in animals, phosphorus metabolism and adrenaline, choline, In addition to the synthesis of creatine, it is also a raw material for the synthesis of protein and cystine. Methionine is widely used in the fields of medicine, food, feed and cosmetics, among which a large amount is used as a feed additive. The global demand for methionine has reached 1.6 million tons per year, and the demand for methionine in China in 2014 exceeded 130,000 tons. Foreign imports, domestic production cannot meet demand. [0003] At present, there are tw...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C319/20C07C323/58
Inventor 吴传隆秦岭李欧王用贵姚如杰郑道敏
Owner NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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