Application of tanshinone II A in preparing medicine for curing tendon adhesion
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A technology of tendon adhesion and tanshinone, applied in the field of medicine
Inactive Publication Date: 2015-08-19
THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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[0011] At present, there are no effective drugs and methods that can completely solve the problem of tendon adhesion. Local injection of traditional Chinese medicine has the advantages of overall dynamic adjustment and individualized treatment.
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Embodiment 1
[0042] The making of embodiment 1 Achilles tendon adhesion rat model
[0043] Experimental animals: SD rats, male, about 350 g, SPF grade, provided by the Experimental Animal Center of Zhejiang University School of Medicine.
[0044] The making of Achilles tendon adhesion rat model: intraperitoneal injection of phenobarbital (4% phenobarbital, 40mg / kg) anesthetized rats, 0.15cm incision on the calcaneus of the right hind leg, about 2cm long, with improved Rothkopf and Peterson's experimental injury method: Take a 0.5cm long Achilles tendon, peel off the tendon sheath, and use Kocher forceps to clamp 10 times from the distal end to the proximal end. Each time, the clamps are buckled to the bottom, and then released after 1 second. Cut through the tendon longitudinally three times, resulting in crushing and bruising cuts, local pressure to stop the bleeding, suture the wound, aseptic bandage, fix the knee joint flexion, ankle joint plantar flexion, and toes to the natural positi...
Embodiment 2
[0045] Example 2 Observation of Tanshinone IIA Preventing and Treating Achilles Tendon Adhesion in Rats
[0046] Get 64 SD rats after modeling in Example 1 and divide them into Danshen group and blank group. The Danshen group is treated as local injection of Tanshinone IIA Sodium Sulfonate Injection (trade name: Nuoxinkang 2mL / Branch, Shanghai No. 1 Biochemical Pharmaceutical Factory) 0.5mL, injected once; the blank group was treated with injection of 0.5mL normal saline, and the operation steps were the same as above. After 6 weeks, the rats were sacrificed, during which the rats were generally observed, and after the sacrifice, the general observation and histological observation were carried out.
[0047] (1) General observation: Dynamic observations were made on the mental state, activity, fur, body weight, and Achilles tendon wound healing of the rats. Rats in the Danshen group and the blank group survived, the wounds healed by first intention, and no infection and disu...
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Abstract
The invention discloses application of tanshinone II A in preparing medicine for curing tendon adhesion, and belongs to the technical field of medicine. After a heel tendon adhesion rat model is manufactured, tanshinone II A sulfonic acid natrium local injection is carried out on heel tendon of the heel tendon adhesion rat model, and the heel tendon adhesion conditions are compared through a contrast to a blank group, and a histological observation and a statistical analysis are carried out. The result shows that in a general observation, the heel tendon adhesion of a salvia miltiorrhiza group is less than that of the blank group, and p is less than 0.05, and statistical difference exists; in the histological observation, the quantities of collagenous fiber and fibroblasts of the salvia miltiorrhiza group are increased by comparing with common heel tendon tissue; the arrangement is relatively regular; the quantities of collagenous fiber and fibroblasts of the blank group are obviously increased, and the arrangement is irregular; The Real-time PCR found that the expression of TGF(transforming growth factor)-beta 1 of the salvia miltiorrhiza group is obviously reduced relative to that of the blank group. The results show that the tanshinone II A has the function of inhibiting the generation and development of tendon adhesion, and can be used for preparing medicine for curing tendon adhesion.
Description
technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of tanshinone IIA in the preparation of medicine for treating tendon adhesion. Background technique [0002] Tendon adhesion refers to the hyperplasia and invasion of surrounding tissues during tendon injury repair, resulting in tendon motor dysfunction. Tendon adhesion after trauma is one of the common problems after tendon injury, and it is one of the unsolved problems in hand surgery. So far, there is still no effective solution. [0003] The reason for tendon adhesion may be that mechanical and chemical injury induce interstitial cells and mast cells to release a variety of active substances, including thrombin, histamine, heparin and other vasoactive substances, causing tissue inflammation, capillary Increased vascular permeability, a large amount of serous exudation. If these exudates cannot be decomposed and absorbed, they will promote the accumulation of ...
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P41/00
Inventor 卢荟沈向前杨虎沈辉陈强吴守成
Owner THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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