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Astragalus membranaceus extract, astragalus membranaceus tablet and preparation method thereof

An extract of Astragalus membranaceus, the technology of Astragalus membranaceus, applied in the field of medicine, can solve the problems of undisclosed extraction process steps and parameters, complicated post-processing process, and affecting the active components of Astragalus membranaceus extract or its ratio, so as to achieve ideal curative effect, effective absorption and utilization , the effect of a large drug effect

Active Publication Date: 2015-07-22
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the reports on the bionic extraction of Astragalus include: Chen Xin, et al., Comparative Study on Biomimetic Extraction and Water Extraction of Astragalus, Xinglin Traditional Chinese Medicine, Volume 29, No. 12, December 2009; the extraction method is full bionic extraction, The process needs to add pepsin, and the extraction temperature is controlled at 37 degrees; and the detailed extraction process steps and parameters are not disclosed; because pepsin is added to the process, it will inactivate or degrade more than one active ingredient in Astragalus. The treatment process is more complicated, and the medicinal liquid or reaction liquid contains unnecessary proteins and polypeptides, which will also affect the active ingredients or their ratio of Astragalus extract

Method used

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  • Astragalus membranaceus extract, astragalus membranaceus tablet and preparation method thereof
  • Astragalus membranaceus extract, astragalus membranaceus tablet and preparation method thereof
  • Astragalus membranaceus extract, astragalus membranaceus tablet and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0030] Preparation of the reference substance in the experiment: Accurately weigh an appropriate amount of the reference substance of astragaloside IV, add methanol to make a solution containing 0.5 mg per m1, and set aside.

[0031] The preparation of need testing solution: get extractum (dry) 10 grams or preparation 20. (The film coat needs to be removed from the tablet), accurately weighed, ground into fine powder, and about 4g was taken; again accurately weighed. Place in a Soxhlet extractor, add 40ml of methanol, heat, reflux for 4 hours, extract the solvent under reduced pressure, and concentrate to dryness. Add 10ml of water to the residue, heat slightly to dissolve it, and extract 4 times with n-butanol saturated with water, 40ml each time. Combine the n-butanol solutions, and fully wash with 40% ammonia test solution 2 to 4 times, 40ml each time. Take n-butanol solution and evaporate to dryness. The residue was dissolved by adding 5ml of water, and allowed to cool....

Embodiment 1

[0034] Example 1 Extraction times investigation test in Astragalus extracting process of the present invention

[0035] The original medicinal material of Radix Astragali is used as a raw material, adding 10 times of its weight in water, adjusting the pH value to 2.0-2.5, extracting at 45-65°C, extracting for 2-4 hours, concentrating the extract to prepare an extract. Investigate the influence of different extraction times on the dry paste rate of the extract and the content of astragaloside IV in the extract, so as to determine the extraction times. The test results are shown in Table 1.

[0036] Table 1 The influence of water extraction times on the extraction effect

[0037]

[0038] The results in Table 1 show that increasing the number of extractions can improve the extraction effect, but when the number of extractions exceeds 2, the effect on the extraction effect is not much different.

Embodiment 2

[0039] In the extraction method of the present invention in embodiment 2, the impact of adding water times amount

[0040] Take the raw medicinal material of Astragalus membranaceus, add water with different multiples of the weight of the raw material, adjust the pH value to 2.0-2.5, and extract the temperature at 45-65°C, perform two extractions, each extraction time is 2 hours, and the dry paste rate of the extract is And the content of astragaloside IV in the extract was used as an index, and the influence of different water additions on the extraction effect of the first decoction and the second decoction were investigated respectively. The test results are shown in Table 2:

[0041] Table 2, the influence of water consumption on the extraction effect during extraction

[0042]

[0043] The results showed that the amount of water added in the first decoction and extraction ranged from 8 to 14 times, and there was little difference in the extraction effect. From the persp...

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Abstract

The invention provides a preparation method of an astragalus membranaceus extract. The preparation method comprises the following steps: a, taking astragalus membranaceus, adding water which has the weight of 8-12 times that of the astragalus membranaceus, regulating pH value to 2.0-2.5, extracting for 2-4 hours at 45-65 DEG C, and filtering to obtain filter residues, and filtrate for use; b, taking the filter residues obtained in the step a, adding water which has the weight of 6-8 times that of the astragalus membranaceus, extracting, regulating the pH value to 8.5-9.5, extracting for 2-4 hours at 45-65 DEG C, and filtering to obtain filtrate for use; c, mixing the filtrate obtained in the step a and the filtrate obtained in the step b, and regulating the pH value to 6.5-7.5; reducing the pressure to -0.03 Mpa to -0.08 Mpa, and concentrating to obtain an extract with the relative density of 1.12-1.50 (30-45 DEG C), namely the astragalus membranaceus extract. The invention further provides a preparation containing the astragalus membranaceus extract. The astragalus membranaceus extract is prepared into corresponding oral preparations, such as capsules, tablets, granules and the like; the prepared preparation is high in effective component content, stable in quality and good in reproducibility, so that a stable and reliable therapeutic effect is guaranteed to a maximum extent.

Description

technical field [0001] The invention relates to an astragalus extract, astragalus tablets and a preparation method thereof, belonging to the field of medicines. Background technique [0002] Astragalus is a traditional Chinese medicinal material commonly used in clinical practice. Astragalus tablet is a classic prescription recorded in the standard issued by the State Food and Drug Administration, the standard number is YBZ12262009, and it is a conventional preparation prepared from Astragalus medicinal material by water extraction and alcohol precipitation. Its functions and indications are to invigorate qi and strengthen the exterior. For shortness of breath, palpitations, spontaneous sweating, etc. When prescribed in hospitals, it is more widely used and can be used for shortness of breath, palpitations, prostration, physical weakness, edema, tumor chemoradiotherapy and after surgery, chronic kidney disease, chronic diarrhea, prolapse of the anus, uterine prolapse, gyne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/48A61K9/20A61K9/16A61P9/06A61P39/00A61P7/10A61P35/00A61P13/12A61P1/10A61P1/00A61P15/00A61P37/04
Inventor 任娅莉石万棋史成刚孙晓琳刘芳
Owner SICHUAN GUOKANG PHARMA
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