Green process for preparing diosgenin

Abstract

The invention discloses a green process for preparing diosgenin and belongs to the technical field of natural product extraction. The main procedure of the process comprises the steps of washing, smashing, naturally fermenting, emulsifying, separating fibers, separating starch, separating emulsion, performing acidolysis, separating oil and water, performing reduced-pressure condensing, and recrystallizing to get the product; recovering acid and monosaccharide in the acidolysis solution through a simulated moving bed; and adding a nonpolar solvent into a natural fermentation solution while grinding by a colloid mill, emulsifying the diosgenin to form the emulsion fixed in the water, and separating to get the cellulose, starch, supernate and emulsion after emulsifying. The emulsion is directly acidolysis processed so that the hydrolysis condition is reduced, the diosgenin is free of being damaged, and the quality of the diosgenin is increased; the pollution source is completely eliminated by the acid and the monosaccharide in the acidolysis solution. The process meets the standards of high purity, high yield, low cost and pollution free. The prepared diosgenin content is greater than 98%, the yield is greater than 80%, the recovery rate of the cellulose, the starch and the like is greater than 95%, the production cost is reduced by 30%, the ton cost is reduced by **-** and no pollution is discharged.

Description

technical field [0001] The invention relates to a green process for preparing diosgenin, which belongs to the technical field of natural product extraction. Background technique [0002] The hydrolyzed product of diosgenin, diosgenin, is the basic raw material for the synthesis of more than 60 kinds of steroid hormones and contraceptive drugs, and the latter is an indispensable basic drug for modern medicine, constituting the second largest class of drugs after antibiotics. The international demand for high-quality diosgenin has been stable at about 1,000-1,200 tons (equivalent to about 8,000-9,000 tons of crude product). 75% of diosgenin is derived from dioscin, and my country has resources of dioscens scutellaria, and the output of diosgenin ranks first in the world for many years. In recent years, the monopoly position of Chinese saponin in the international market has been seriously threatened. First of all, the price of diosgenin in my country is far lower than th...

AI Technical Summary

Problems solved by technology

However, there are three major defects in this type of method: 1. Microorganisms may destroy part of saponin, so its saponin increase is not significant; 2. The introduction of microbial secondary metabolic impurities reduces the quality of saponin; 3. Fermentation products are not dioscin Elements have become the main industry, introducing new competitive risks, and the uncertainty of enterprises is expected to increase

[0013] In summary, the currently disclosed methods have not yet fully met the four standards of high purity, high yield, low cost, and cleanliness. The relatively perfect natural fermentation-total glycoside alcohol extraction-acid hydrolysis method still needs to further improve the yield of saponin , quality, cost reduction and comprehensive utilization of acid hydrolyzate (recovery of acid and sugar)

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