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Oral composition and preparation method thereof

A composition and oral technology, applied in the field of daily chemical products, to achieve the effect of protecting oral health, fast foaming, stable color and smell

Active Publication Date: 2015-06-10
耿福能
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN102861116 discloses a method for preparing pomegranate peel polyphenol toothpaste for treating gynecological inflammation, and the prepared toothpaste is used to prevent and treat gynecological inflammation vaginitis and cervicitis caused by bacteria; patent CN102973608 discloses a cockroach extract The effective parts of the drug are used to prepare drugs for inhibiting fungal growth, and the prepared pharmaceutical preparations are used to prepare pharmaceutical preparations, medical devices, and daily chemical products for preventing and treating fungal infections; the disclosed toothpaste preparations use pomegranate peel polyphenols or Kangfuxin extract alone Preparations, the toothpaste prepared with Kangfuxin and pomegranate peel polyphenols has not been reported

Method used

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  • Oral composition and preparation method thereof
  • Oral composition and preparation method thereof
  • Oral composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0066] Preparation of pomegranate polyphenols:

[0067] a. Take pomegranate peel powder and grind it into coarse powder, add 8 times the concentration of 75% ethanol to extract 3 times, 1.5 hours each time, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to 0.1-0.3g of crude drug per ml Concentrate;

[0068] b. Add the concentrated solution obtained in step a to the processed HPD100 type perforated adsorption resin column, adsorb for 15 hours, first rinse with deionized water until the color of the effluent is lighter, and then use 6 times the column volume of 50% Ethanol elution, collecting alcohol-containing eluate, recovering ethanol, concentrating under reduced pressure and vacuum drying to form an extract, crushed, and sieved through a 100 mesh sieve to obtain pomegranate polyphenols.

[0069] The rest of the raw materials are available on the market

[0070] The distribution ratio of each group in Example 1-3 and Reference Example 1-2 is ...

experiment example 1

[0087] Experimental example 1 Screening of the optimal ratio of American cockroach extract and pomegranate polyphenols

[0088] Strains: Escherichia coli, Staphylococcus aureus (provided by Chengdu University of Traditional Chinese Medicine)

[0089] Medium: nutrient agar medium

[0090] Main instruments: electronic balance DS-101S (Shimadzu Corporation of Japan), constant temperature water bath (Zhengzhou Great Wall Science and Industry Trading Co., Ltd.), RE-52A rotary evaporator (Shanghai Yarong Biochemical Instrument Factory), DHG-9623A constant temperature incubator ( Shanghai Jinghong Test Equipment Co., Ltd.), LS-S11 automatic vertical electric pressure steam sterilizer (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory)

[0091] Preparation of bacterial suspension:

[0092] The test bacteria were inoculated on the corresponding slant medium, the bacteria were cultured at 37°C for 24 hours, and the activated bacteria were mixed with sterile saline (10 6 -10 7 ) / ml ba...

experiment example 2

[0104] Experimental example 2 The specific application of toothpaste loaded with Periplaneta americana extract and pomegranate polyphenols in oral problems

[0105] 1. Application of toothpaste loaded with Periplaneta americana extract and pomegranate polyphenols in oral ulcers and sores on the mouth and tongue:

[0106] 1.1 Test subjects: patients with oral ulcers, mouth and tongue sores

[0107] 1.2 Experimental grouping:

[0108] 1.2.1 100 patients with oral ulcers meet the diagnostic criteria. They were randomly divided into control group and treatment group. There were 50 patients in the treatment group, 30 males and 20 females, aged 20-55 years; in the control group, 50 patients, 27 males and 23 females, aged 20-55 years. The age, gender and disease course of the two groups of patients were statistically processed, and the differences were not significant and comparable.

[0109] 1.2.2 100 patients with sores on the tongue and mouth meet the diagnostic criteria. Randomly divid...

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Abstract

The invention provides an oral composition which is an oral preparation prepared by taking Periplaneta americana extract and Punicosides as active ingredients, wherein the weight ratio of the Periplaneta americana extract to Punicosides is 1:1-1:5. The invention also provides a preparation method and application of the oral composition. According to the oral composition disclosed by the invention, toothpaste can perform synchronous nursing on the oral cavity, teeth and gingiva and can effectively solve dental ulcer, the Punicosides have high in-vivo anti-oxidation and free radical cleaning activities, and the oral composition has a broad-spectrum antibacterial effect, has obvious effects of inhibiting staphylococcus aureus, hemolytic streptococcus, comma bacillus and shigella dysenteriae and has the effects of astringing, stopping bleeding, improving eyesight and the like.

Description

Technical field [0001] The invention belongs to the technical field of daily chemicals, and particularly relates to a composition for cleaning the oral cavity with antibacterial, antiviral, wound repair, anti-inflammatory and analgesic effects and a preparation method thereof. Background technique [0002] As a traditional Chinese medicine, pomegranate peel is included in the historical pharmacopoeias of China. It has the effects of astringent intestines to stop diarrhea, hemostasis, and deworming. According to modern pharmacological research, pomegranate peel also has antiviral, antibacterial, immune regulation, and antioxidant effects. Because the tannin in pomegranate peel can coagulate the protoplasm in the microorganisms and affect various enzymes, it has an inhibitory effect on a variety of bacteria and fungi. The literature reports that the extract of pomegranate peel has an effect on Staphylococcus aureus, Salmonella, and large intestine. Bacillus, Aspergillus niger, Pseu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/97A61Q11/00A61P1/02
Inventor 耿福能
Owner 耿福能
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