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Europium-doped titanium dioxide/graphene oxide composite film and preparation method thereof

A graphene composite and titanium dioxide technology, applied in the direction of material excitation analysis, etc., can solve the problems of in-situ characterization of protein adsorption, achieve good adsorption, low cost, and simple PL test

Active Publication Date: 2015-05-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Nowadays, many methods such as BCA can detect the amount of protein adsorption, but these methods are basically unable to characterize the amount of protein adsorption in situ

Method used

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  • Europium-doped titanium dioxide/graphene oxide composite film and preparation method thereof
  • Europium-doped titanium dioxide/graphene oxide composite film and preparation method thereof
  • Europium-doped titanium dioxide/graphene oxide composite film and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0023] 1) Using the sol-gel method, the titanium dioxide precursor sol uses tetrabutyl titanate (TBOT) as the titanium source, ethanol as the solvent, and adds europium source Eu(TMHD) 3 , complexing agent acetylacetone (AcAc) and polyvinylpyrrolidone (PVP), the concentration of tetrabutyl titanate is 0.1 mol / L, Eu(TMHD) 3 The concentration was 0.01 mol / L, the molar ratio of acetylacetone, deionized water and tetrabutyl titanate was 0.3:1:1, stirred at room temperature to form a homogeneous sol; then, 20 μL of the precursor sol was taken at 8000 rpm Spin coating on the surface of the silicon wafer at a high speed, and the spin coating time was set at 40 s; after the spin-coated sample was kept at 500 °C for 2 h, a europium-doped titanium dioxide film without graphene oxide was obtained (see SEM image figure 1 ). The size of titanium dioxide nanodots is mostly 95-110 nm, and the density is about 5.4×10 10 / cm 2 .

Embodiment 2

[0025] 1) First, graphene oxide and Eu(TMHD) 3 Add to absolute ethanol, stir until Eu(TMHD) 3 After completely dissolving, add tetrabutyl titanate (TBOT), complexing agent acetylacetone (AcAc) and deionized water, the molar ratio of acetylacetone, deionized water and tetrabutyl titanate is 0.3:1:1, Then add polyvinylpyrrolidone, stir well at room temperature, prepare tetrabutyl titanate concentration of 0.1 mol / L, polyvinylpyrrolidone concentration of 40 g / L, Eu(TMHD) 3 Concentration is 0.01 mol / L, and the concentration of graphene oxide is the titania precursor sol of 10 mg / L;

[0026] 2) Drop the titania precursor sol onto the cleaned silicon wafer surface until it is covered, spin-coat at 8000 rpm for 40 s, and then keep it at 500 °C for 2 h to obtain Eu-doped titania / oxide Graphene composite film. Its SEM image is shown in figure 2 , the size of titanium dioxide nanodots is mostly 90-105 nm, and the density is about 5.2×10 10 / cm 2 .

[0027] This example is compa...

Embodiment 3

[0029] 1) First, graphene oxide and Eu(TMHD) 3 Add to absolute ethanol, stir until Eu(TMHD) 3 After completely dissolving, add tetrabutyl titanate, complexing agent acetylacetone and deionized water, the molar ratio of acetylacetone, deionized water and tetrabutyl titanate is 0.3:1:1, then add polyvinylpyrrolidone, Stir well at room temperature, prepare tetrabutyl titanate concentration of 0.1 mol / L, polyvinylpyrrolidone concentration of 35 g / L, Eu(TMHD) 3 Concentration is 0.012 mol / L, and the concentration of graphene oxide is the titania precursor sol of 8 mg / L;

[0030] 2) The titania precursor sol was dropped onto the cleaned quartz glass surface until it was covered, and spin-coated at 8000 rpm for 40 s, and then kept at 500 °C for 2 h to obtain Eu-doped titania / Graphene oxide composite film, the size of titanium dioxide nano-dots is mostly 94-110 nm, and the density is about 5.1×10 10 / cm 2 .

[0031] The PL test was performed on the sample prepared in this example,...

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Abstract

The invention discloses a europium-doped titanium dioxide / graphene oxide composite film and a preparation method thereof. According to the film, a substrate is provided with a europium-doped titanium dioxide nanodot and graphene oxide mixed layer, wherein titanium dioxide nanodots in the mixed layer are 30-150nm in size and 1.0*10<10>-1.0*10<11> / cm<2> in density, the molar concentration of Eu<3+> is 0.005-0.015mol / L, and the concentration of graphene oxide is 5-15mg / L. The preparation method is based on a sol-gel method and comprises the steps of preparing europium-doped titanium dioxide / graphene oxide precursor sol and then performing thermal treatment of the precursor sol on the substrate by a spin-coating method. The film provided by the invention has favorable biocompatibility, protein adsorption property and luminescence property, and can be used for in-situ semi-quantitative characterization of the protein adsorption capacity of a film surface. The film can be applied in the biomedical engineering fields of cell culture in vitro, tissue engineering and the like.

Description

technical field [0001] The invention belongs to the field of biomedical thin films, and in particular relates to a europium-doped titanium dioxide / graphene oxide composite thin film and a preparation method thereof, which can be used for in-situ semi-quantitative characterization of protein adsorption on the surface of materials. Background technique [0002] Titanium dioxide is a non-toxic material with good biocompatibility and chemical stability, which is widely used in the medical field and is developing rapidly. Studies have shown that mouse calvaria-derived preosteoblast MC3T3-E1 cells grow well on the surface of titanium dioxide nanodots [Y. Hong, M. F. Yu, W. J. Weng, K. Cheng, H. M. Wang, J. Lin. Light-induced cell detachment for cell sheet technology. Biomaterials, 2013,34(1):11-18], no cytotoxicity. [0003] Graphene oxide is widely studied as one of the derivatives of graphene, and it is considered to have great development prospects in biomaterial application e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/63C03C17/22C04B41/50
Inventor 程逵朱翼飞翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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