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A biological material containing PEG or its derivatives

A technology of biological materials and derivatives, applied in bandages, absorbent pads, medical science, etc., can solve the problems of cumbersome, poor wound use effect, poor adhesive strength, etc., and achieve rapid hemostasis, easy to use, beautiful and complete appearance Effect

Active Publication Date: 2018-01-09
GUANGZHOU BEIT SONG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fibrin glue is very cumbersome to use and needs to be prepared a certain time in advance. In addition, its adhesive strength is not good, and the effect on wounds with a large amount of bleeding is poor.

Method used

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  • A biological material containing PEG or its derivatives
  • A biological material containing PEG or its derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A biological product / biological material containing PEG or its derivatives, comprising the main components of fibrinogen, thrombin, albumin, coagulation factor XIII derived from mammalian plasma, and coagulation factor derived from mammalian skin, cartilage, and Achilles tendon Collagen; and Auxiliary Ingredients containing PEG or its derivatives. The preparation method of biological product / biological material comprises the following steps:

[0025] (1) the main raw material is fibrinogen, and the auxiliary raw material is the mixed solution of the XIII blood coagulation factor, sugar, sugar alcohol, amino acid, salt, vitamin, PEG and is placed in the mold box and frozen to form the first solid;

[0026] (2) Spraying the main raw material on the frozen first solid is thrombin, the auxiliary raw material is a mixed solution of salt and amino acid, and rapidly freezes to form a second solid;

[0027] (3) Pour the collagen solution on the frozen second solid, and quickly...

Embodiment 2

[0032] A biological product / biological material containing PEG or its derivatives, comprising the main components of fibrinogen, thrombin, albumin, coagulation factor XIII derived from mammalian plasma, and coagulation factor derived from mammalian skin, cartilage, and Achilles tendon Collagen; and Auxiliary Ingredients containing PEG or its derivatives. The preparation method of biological product / biological material comprises the following steps:

[0033] (1) the main raw material is fibrinogen, and the auxiliary raw material is the mixed solution of the XIII blood coagulation factor, sugar, sugar alcohol, amino acid, salt, vitamin, PEG derivative and is placed in the mold box and frozen to form the first solid;

[0034] (2) Spraying the main raw material on the frozen first solid is thrombin, and the auxiliary raw material is a mixed solution of salt, amino acid and PEG derivative, and rapidly freezes to form a second solid;

[0035] (3) Pour the collagen solution on the f...

Embodiment 3

[0041] A biological product / biological material containing PEG or its derivatives, comprising the main components of fibrinogen, thrombin, albumin, coagulation factor XIII derived from mammalian plasma, and coagulation factor derived from mammalian skin, cartilage, and Achilles tendon Collagen; and Auxiliary Ingredients containing PEG or its derivatives. The preparation method of biological product / biological material comprises the following steps:

[0042] (1) The main raw material is fibrinogen, and the auxiliary raw material is the mixed solution of the XIII blood coagulation factor, sugar, sugar alcohol, amino acid, salt, vitamin, PEG and is placed in the mold box to freeze to form the first solid;

[0043] (2) Spraying the main raw material on the frozen first solid is thrombin, and the auxiliary raw material is a mixed solution of salt, amino acid and PEG, and rapidly freezes to form a second solid;

[0044] (3) Pour the mixed solution of collagen and PEG on the frozen ...

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Abstract

A biological material containing PEG or its derivatives, including fibrinogen, thrombin, albumin, blood coagulation factor XIII as the main components derived from mammalian plasma, and collagen derived from mammalian skin, cartilage and Achilles tendon; and auxiliary ingredients containing polyethylene glycol or its derivatives. Biological products / biological materials contain main components such as fibrinogen, thrombin, albumin, coagulation factor XIII, collagen, and auxiliary components such as PEG or its derivatives, sugar, sugar alcohol, amino acid, salt, vitamin, etc. The formula composition and ratio have a very important impact on the preparation, appearance, stability, and efficacy of the product, and the addition of PEG or its derivatives can significantly improve the product performance.

Description

technical field [0001] The present invention relates to a biomedical product, especially a hemostatic biological product / biological material that can be absorbed by a biological body and can be used in clinical operations and emergency situations for auxiliary hemostasis, wound closure, and promotion of wound healing. Background technique [0002] Bleeding is the main symptom after trauma, and excessive bleeding can lead to shock and even death. Effective hemostasis and reduction of bleeding volume are major issues that need to be solved in surgery, and are also key issues in reducing mortality in combat trauma, which play a decisive role in saving lives. The tourniquet is a life-saving device that can control bleeding, but it cannot be used or is invalid for many parts of the human body such as the chest, abdomen, head, neck and other tourniquets. Traditional hemostatic materials (such as cotton gauze and bandages) are not ideal for the hemostatic effect of common wounds s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/26A61L15/44A61L15/42
Inventor 黄志霞李若冰万德夫付岩霖朱晋辉李敏万华印
Owner GUANGZHOU BEIT SONG PHARMA TECH CO LTD
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