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Organic composite hydrogel cross-linked by modified gelatin nano-microsphere and preparation method of organic composite hydrogel

A technology of composite hydrogels and nano-microspheres, applied in the field of biomedical materials, can solve the problems that have not yet been seen, and achieve the effects of improving biocompatibility, low cost, and mild preparation conditions

Active Publication Date: 2015-03-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no patent reports on the preparation of organic composite hydrogels using modified gelatin nanospheres as crosslinking agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 0.4g of modified gelatin nanospheres with a substitution degree of 35% into a 20mL stoppered glass bottle, then add 1.0g of N-isopropylacrylamide monomer and 10mL of deionized water, blow in nitrogen, and stir for 30min until A homogeneous dispersion is formed. Then add 100 μL of N,N,N',N'-tetramethylethylenediamine solution with a concentration of 10% by mass, mix well and continue to pass nitrogen gas for 10 minutes, then add 200 μL of ammonium persulfate solution with a concentration of 4% by mass. Then seal it quickly and place it at -20 o After reacting in C water bath for 24h, the reactant was taken out and soaked in 20 o C deionized water for 48 hours, changing the deionized water every 8 hours, the organic composite hydrogel with fast response and good mechanical properties was obtained.

Embodiment 2

[0024] Add 0.2g of modified gelatin nanospheres with a substitution degree of 60% into a 20mL stoppered glass bottle, then add 1.0g of acrylamide monomer and 10mL of deionized water, blow in nitrogen, and stir for 30min until a uniform dispersion is formed . Then add 100 μL of N,N,N',N'-tetramethylethylenediamine solution with a concentration of 10% by mass, mix well and continue to pass nitrogen gas for 10 minutes, then add 200 μL of ammonium persulfate solution with a concentration of 4% by mass. Then seal it quickly and place it at -40 o After reacting in C water bath for 24h, the reactant was taken out and soaked in 20 o C deionized water for 48 hours, changing the deionized water every 8 hours, the organic composite hydrogel with fast response and good mechanical properties was obtained.

Embodiment 3

[0026]Add 0.1g of modified gelatin nanospheres with a substitution degree of 60% into a 20mL stoppered glass bottle, then add 1.0g of N-isopropylacrylamide monomer and 10mL of deionized water, blow in nitrogen, and stir for 30min until A homogeneous dispersion is formed. Then add 100 μL of N,N,N',N'-tetramethylethylenediamine solution with a concentration of 10% by mass, mix well and continue to pass nitrogen gas for 10 minutes, then add 200 μL of ammonium persulfate solution with a concentration of 4% by mass. Then seal it quickly and place it at -10 o After reacting in C water bath for 24h, the reactant was taken out and soaked in 20 o C deionized water for 48 hours, changing the deionized water every 8 hours, the organic composite hydrogel with fast response and good mechanical properties was obtained.

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Abstract

The invention provides an organic composite hydrogel cross-linked by a modified gelatin nano-microsphere and a preparation method of the organic composite hydrogel. Specifically, the preparation method comprises the following steps: preparing a modified gelatin nano-microsphere by virtue of a two-step solvent removal process, then respectively dissolving an acrylamide monomer and the modified gelatin nano-microsphere in de-ionized water and stirring in an inert atmosphere for 5-30min; adding a catalyst, stirring in the inert atmosphere for 5-10min, and adding an initiator; carrying out a free radical polymerization reaction at minus 40-40 DEG C for 12-48hr; and soaking a reactant in de-ionized water at 20 DEG C, replacing the de-ionized water once every other 5-8hr, and keeping for 48-72hr to obtain the organic composite hydrogel. The method disclosed by the invention is simple in process and controllable in condition, and the prepared organic composite hydrogel integrates the characteristics of a nano composite material and covalent cross-linking and has the characteristics of being good in biocompatibility, mechanical property, macro-porous property, rapid swelling property and the like; and the organic composite hydrogel can be widely applied to the biomedical materials of biological scaffold, cell culture, medicine controlled release, tissue engineering and the like.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a modified gelatin nano microsphere cross-linked organic composite hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of hydrophilic polymer with obvious three-dimensional network structure, which can swell in water without dissolving. Hydrogels have excellent permeability, water absorption, and biocompatibility, so they are widely used in the fields of biomedical materials such as bioscaffolds, cell culture, drug controlled release, and tissue engineering. However, due to the use of chemical cross-linking agents or light irradiation to prepare traditional hydrogels, they usually have the disadvantage of poor mechanical properties, which greatly limits the wider application of hydrogels in tissue engineering scaffold materials. Therefore, many researchers have focused their efforts on how to improve the mechanical properties of hydroge...

Claims

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Application Information

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IPC IPC(8): C08F290/00C08F220/56C08F220/54C08J9/28C08J3/12C08J3/075
Inventor 林炜李昌朋穆畅道王春华
Owner SICHUAN UNIV
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