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Traditional Chinese medicine composition for treating parkinson disease

A technology of Parkinson's disease and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of Parkinson's disease, can solve the problems of unable to prevent the death of dopaminergic neurons, apoptosis of nerve cells, and affecting the treatment effect and quality of life of patients, and achieve relief Effects of oxidative stress damage in the body, increase of dopamine content, and enhancement of antioxidant levels

Active Publication Date: 2015-03-25
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, dopamine replacement therapy is the main treatment, among which levodopa is the representative. Although its treatment has a rapid onset, many side effects have attracted people's attention, such as "on-off phenomenon" and "end-of-dose phenomenon". , movement disorders, mental abnormalities and other problems; and levodopa itself not only cannot prevent or delay the progressive death of dopaminergic neurons, but can also induce neuronal apoptosis through its own oxidation products
These have greatly affected the treatment effect and quality of life of patients.

Method used

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  • Traditional Chinese medicine composition for treating parkinson disease
  • Traditional Chinese medicine composition for treating parkinson disease
  • Traditional Chinese medicine composition for treating parkinson disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Influence of the traditional Chinese medicine composition of the present invention on the morphology of neuron cells in the substantia nigra and striatum of the Parkinson's disease (PD) model mice

[0022] 1. Preparation of medicinal solution: decoct 1kg of Cistanche deserticola and 0.6kg of Acorus shichangbu with 3.2kg of water twice, the first time for 2 hours, the second time for 1 hour, combine the decoctions, filter, and when the filtrate is concentrated to 50°C, the relative density is 1.20; add ethanol to make the alcohol content in the solution 60%, let it stand for precipitation, take the supernatant, recover the ethanol and concentrate it to a thick paste, take the thick paste and add water to prepare different concentrations of liquid medicine.

[0023] 2. Modeling: take 6-week-old SPF grade C 57 BL / 6J strain male mice were intraperitoneally injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (40 mg·kg -1 d -1 , 1 time / d, for 7 con...

Embodiment 2

[0027] Example 2 Effect of the traditional Chinese medicine composition of the present invention on the content of dopamine (DA) and its metabolites in the substantia nigra-striatum of PD model mice

[0028] The preparation, modeling and administration methods of the medicinal solution are the same as in Example 1.

[0029] Material collection: After the drug administration, the brain was quickly decapitated, and the substantia nigra-striatum was separated in an ice bath, and immediately stored in a -80°C refrigerator for testing. The contents of dopamine (DA) and its metabolite homovanillic acid (HVA) were detected by high performance liquid chromatography. The results are shown in Table 1.

[0030] Table 1 Contents of DA and its metabolites in model rats in each group after administration (x±s, n=10)

[0031]

[0032] It can be seen from the results in Table 1 that the DA content of the model group was significantly lower than that of the normal group ( p p <0.01), t...

Embodiment 3

[0035] Example 3 The effect of the traditional Chinese medicine composition of the present invention on the expression of tyrosine hydroxylase (TH) in PD model mice / MES23.5 dopaminergic nerve cells

[0036] The preparation, modeling and administration methods of the medicinal solution are the same as in Example 1.

[0037] Material collection: After the administration, the mice in each group were quickly decapitated and the brains were taken out, and marked one by one according to the number, the brain tissue was perfused with paraformaldehyde aqueous solution to fix the brain tissue, the substantia nigra was taken out, and the brain was washed with sucrose-containing phosphate buffered saline (PBS ) immersion, conventional paraffin embedding, serial coronal sections (slice thickness 5um), immunohistochemical staining by peroxidase-labeled streptavidin (SP) two-step method, degreasing, hydration, and heat repair, Add rabbit anti-mouse TH monoclonal antibody (primary antibody...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating Parkinson disease. The composition is prepared from 6-15g of cistanche and 6-12g of rhizoma acori graminei, wherein the effect of cistanche in relieving body oxidative stress injury and eliminating free radicals is utilized and is combined with the effect of the rhizoma acori graminei in improving permeability of blood brain barrier to prepare powder, granules, electuary or other traditional Chinese medicine preparations for treating Parkinson disease. Experiments prove that the composition can be used for repairing injured dopaminergic neurons, effectively increasing the content of dopamine in substantia nigra-striatum, up-regulating expression of dopaminergic neurons TH, reducing the degree of brain tissue lipid peroxidation, increasing the antioxidative level in brain and reducing apoptosis of dopaminergic neuron of MPP+ induced Parkinson disease model MES23.5, and does not have remarkable toxins.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for treating Parkinson's disease. Background technique [0002] Parkinson's disease (Parkinson Disease, PD) is a kind of pathology characterized by the degeneration or disappearance of dopaminergic neurons in the nigrostriatum of the midbrain and the abnormal accumulation of α-synuclein in the cells, which causes the formation of Lewy bodies. Nervous system degenerative diseases with clinical manifestations such as resting tremor, muscle rigidity, bradykinesia, and posture and gait disorders. PD is common in middle-aged and elderly people. Epidemiological surveys show that the total number of PD patients in my country has reached more than 1.7 million, of which the prevalence rate of people over 65 years old is about 1.7%. With the aging of the population, the incidence rate is significantly Increase has become one of the mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/16
CPCA61K9/14A61K9/1623A61K9/1652A61K36/64A61K36/888A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 蔡晶叶水芬田允许艺惠
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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