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Application of oligosaccharide

A technology of oligosaccharide and acetaldehyde dehydrogenase, which is applied in medical preparations containing active ingredients, diseases of the digestive system, cardiovascular system, etc., and can solve the problems of undisclosed uses of doctoral thesis

Inactive Publication Date: 2015-09-16
XIANGTAN UNIV
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Problems solved by technology

[0008] But the doctoral dissertation does not disclose its use

Method used

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  • Application of oligosaccharide
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Embodiment

[0014] 1. Experimental method of oligosaccharide α-L-Rhap(1→4)→α-D-Galp for liver protection and activation of acetaldehyde dehydrogenase (ALDH)

[0015] 1) Establishment of mouse acute alcoholic liver injury model and experimental grouping: 120 male Kunming mice were purchased from Changsha Tianqin Biotechnology Co., Ltd., certificate number: SCXK (Xiang) 2009-0012, and the experimental animals were divided into Blank control group, acute alcoholic liver injury model control group, oligosaccharide α-L-Rhap(1→4)→α-D-Galp high, medium and low dose groups, positive drug silibinin group; Male Kunming mice were given 6.4g / kg.bw alcohol (67%, v / v, 12mL / kg.bw) to successfully replicate the mouse model of acute alcoholic liver injury. (1) Blank control group: per kilogram body weight 10mL distilled water in the stomach, 12mL distilled water per kilogram of body weight after 2 hours; (2) Acute alcoholic liver injury model control group: 10mL distilled water per kilogram body weight, 6...

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Abstract

The invention provides the application of oligosaccharide, and particularly discloses the application of oligosaccharide alpha-L-Rhap(1->4)->alpha-D-Galp serving as an acetaldehyde dehydrogenase activating agent, serving as a liver protective agent and in preparation of drugs for treating alcoholic liver diseases.

Description

technical field [0001] The invention provides a new application of oligosaccharide α-L-Rhap(1→4)→α-D-Galp. Background technique [0002] Acetaldehyde dehydrogenase (acetaldehyde dehydrogenase, ALDH) (EC1.2.1.10) (CAS[9028-91-5]), as a kind of aldehyde dehydrogenase, is responsible for catalyzing the oxidation of acetaldehyde to acetic acid. It plays a major role in alcohol metabolism and widely exists in various animals, plants and microorganisms. Mammalian acetaldehyde dehydrogenase can be divided into three categories according to its subcellular localization, structure and dynamic characteristics and the similarity of the original sequence: the first category exists in the cytoplasm (ALDH1), and the second category exists in the mitochondria (ALDH2 ), the third category is the inducible cytoplasmic aldehyde dehydrogenase and the inducible microsomal aldehyde dehydrogenase (such as ALDH3). Aldehyde dehydrogenase 2 (ALDH2) is an aldehyde oxidase that exists in the mitocho...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61K31/702A61P1/16A61P25/28A61P9/00A61P35/00
Inventor 邹晓青文杰彭圣明
Owner XIANGTAN UNIV
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