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Preparation method of veterinary compound levofloxacin injection

The technology of compound levofloxacin and injection is applied in the field of preparation of compound levofloxacin injection for veterinary use, and can solve the problems of easy crystallization failure, occurrence of sepsis, unstable quality and the like, and achieve the effects of ensuring appetite, maintaining vitality and increasing appetite.

Active Publication Date: 2015-03-11
CHONGQING ZONGYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The quality of ofloxacin injection currently on the market is unstable, and it is easy to crystallize and fail
Bacterial infections in livestock and poultry often cause fever and sepsis. Currently, ofloxacin injections on the market can only treat the symptoms but not the root cause

Method used

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  • Preparation method of veterinary compound levofloxacin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Prepare veterinary compound levofloxacin injection according to the following steps:

[0017] 1) Dissolve 45g of levofloxacin hydrochloride with water for injection, add 20ml of propylene glycol, stir and dissolve, and set aside;

[0018] 2) Add 45g of aminopyrine, 35g of nicotinamide, 60ml of propylene glycol, 80ml of N,N-dimethylformamide, and 0.8g of disodium edetate into water for injection, stir to dissolve, and set aside;

[0019] 3) Stir and dissolve 0.8 g of racecolin with water for injection, and set aside;

[0020] 4) Mix the liquids prepared in steps 1, 2, and 3 together, adjust the pH value to 4.0-4.5 with glacial acetic acid, add water for injection to make up to 1000ml, filter aseptically, and potting.

Embodiment 2

[0022] Prepare veterinary compound levofloxacin injection according to the following steps:

[0023] 1) Dissolve 50g of levofloxacin hydrochloride with water for injection, add 30ml of propylene glycol and stir to dissolve, set aside;

[0024] 2) Add 50g of aminopyrine, 40g of nicotinamide, 70ml of propylene glycol, 100ml of N,N-dimethylformamide, and 1.0g of disodium edetate into water for injection, stir to dissolve, and set aside;

[0025] 3) Stir and dissolve 1.0 g of racecolin with water for injection, and set aside;

[0026] 4) Mix the liquids prepared in steps 1, 2, and 3 together, adjust the pH value to 4.0-4.5 with glacial acetic acid, add water for injection to make up to 1000ml, filter aseptically, and potting.

Embodiment 3

[0028] Prepare veterinary compound levofloxacin injection according to the following steps:

[0029] 1) Dissolve 55g of levofloxacin hydrochloride with water for injection, add 30ml of propylene glycol and stir to dissolve, set aside;

[0030] 2) Add 55g of aminopyrine, 45g of nicotinamide, 90ml of propylene glycol, 120ml of N,N-dimethylformamide, and 1.2g of disodium edetate into water for injection, stir to dissolve, and set aside;

[0031] 3) Stir and dissolve 1.2 g of racecolin with water for injection, and set aside;

[0032] 4) Mix the liquids prepared in steps 1, 2, and 3 together, adjust the pH value to 4.5 with glacial acetic acid, add water for injection to make the volume up to 1000ml, filter aseptically, and seal it.

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Abstract

The invention relates to a preparation method of a veterinary compound levofloxacin injection. The preparation method comprises the following steps: (1) dissolving levofloxacin hydrochloride with water for injection, and adding partial formula amount of propylene glycol to the levofloxacin hydrochloride and dissolving for standby use; (2) adding aminopyrine, nicotinamide, remaining formula amount of propylene glycol, N,N-dimethylformamide, ethylene diamine tetraacetic acid (EDTA-2Na) to water for injection, stirring and dissolving for standby use; (3) stirring and dissolving bethanechol with water for standby use; (4) mixing liquid prepared and obtained in the first step, second step and third step together, adjusting the pH value to be 4.0-4.5, adding water for injection to a constant volume, and carrying out aseptic filtration and encapsulation. The prepared injection is more stable in quality and free of side effects, so that the injection has anti-inflammatory, febrifuge and laxative effects at the same time, both symptoms and root causes are treated, and the curative effect is improved.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a preparation method of veterinary compound levofloxacin injection. Background technique [0002] Levofloxacin is the optical isomer of ofloxacin. Its antibacterial activity in vitro is twice that of ofloxacin, and its toxic and side effects are greatly reduced. It is currently one of the best varieties of quinolones. Its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. This product has the characteristics of broad antibacterial spectrum and strong antibacterial effect. For most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter and Pseudomonas aeruginosa Gram-negative bacteria such as Monas, Haemophilus influenzae, and Neisseria gonorrhoeae have strong antibacterial activity, and their antibacterial activity ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K9/08A61P31/04A61P29/00A61P1/14A61P1/10A61K31/455A61K31/4152A61K31/27
CPCA61K9/08A61K31/27A61K31/4152A61K31/455A61K31/5383A61K2300/00
Inventor 梁金权
Owner CHONGQING ZONGYI PHARMA
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