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A kind of white cauliflower oil suppository and preparation method thereof

A technology of rapeseed oil suppositories and cauliflower seeds, which is applied in suppository delivery, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problem of low bioavailability of cauliflower oil, achieve the effect of improving bioavailability and effectively treating hemorrhoids

Active Publication Date: 2018-09-11
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cauliflower seed is mainly used internally (decoction) and external application (decoction and fumigation), because the main active ingredients that exert its external function are volatile oils. Utilization rate is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A white cauliflower oil suppository consists of the following components in parts by weight: 1-3 parts of white cauliflower oil, 7-9 parts of base, and 0.1-1 part of absorption accelerator.

[0018] A preparation method of cauliflower oil suppository, comprising the following steps:

[0019] (1) Extraction of cauliflower oil:

[0020] ①Crush the cauliflower seeds and pass through a 40-60 mesh sieve for later use;

[0021] ②5-10 times of distilled water impregnated cauliflower seeds for 0.5-1.5h;

[0022] ③ Heating, distillation and extraction for 5-8 hours, and cooling to separate the volatile oil.

[0023] (2) Preparation of cauliflower oil suppositories:

[0024] Weigh 7-9 parts by weight of the substrate, heat and melt in a water bath at 60°C-80°C, add 0.1-1 part of absorption enhancer and 1-3 parts of volatile oil of cauliflower, stir well to make it uniform, and keep warm at 50°C-60 ℃, pour it into a suppository mold coated with liquid paraffin, take it out aft...

Embodiment 2

[0027] A cauliflower oil suppository consists of the following components in parts by weight: 10 g of cauliflower oil, 80 g of base, and 10 g of absorption enhancer.

[0028] A preparation method of cauliflower oil suppository, comprising the following steps:

[0029] (1) Extraction of cauliflower oil:

[0030] ① Crush cauliflower seeds into powder, pass through a 40-mesh sieve for later use;

[0031] ② Weigh an appropriate amount of the above-mentioned cauliflower seed powder, add 5 times of distilled water and soak for 1 hour;

[0032] ③Subsequently heated and distilled to extract for 6 hours, and cooled to separate the volatile oil.

[0033] (2) Preparation of cauliflower oil suppositories:

[0034] Weigh the raw materials according to the following ratio:

[0035] White cauliflower oil: 10g

[0036] Glycerin gelatin: 56g

[0037] Macrogol 4000: 24g

[0038] Tween-80: 6g

[0039] Potassium sorbate: 4g

[0040] Heat glycerin gelatin and polyethylene glycol 4000 in a...

Embodiment 3

[0042] A cauliflower oil suppository consists of the following components in parts by weight: 10 g of cauliflower oil, 80 g of base, and 10 g of absorption enhancer.

[0043] A preparation method of cauliflower oil suppository, comprising the following steps:

[0044] (1) Extraction of cauliflower oil

[0045] ① Crush cauliflower seeds into powder, pass through a 50-mesh sieve for later use;

[0046] ② Weigh an appropriate amount of the above-mentioned cauliflower seed powder, add 6 times of distilled water and soak for 1 hour;

[0047] ③Then heated and distilled to extract for 5 hours, and cooled to separate the volatile oil.

[0048] (2) Preparation of cauliflower oil suppositories:

[0049] Weigh the raw materials according to the following ratio:

[0050] White cauliflower oil: 10g

[0051] Glycerin gelatin: 70g

[0052] Macrogol 1000: 10g

[0053] Sodium dodecyl sulfonate: 7g

[0054] Potassium sorbate: 3g

[0055] Heat glycerin gelatin and polyethylene glycol 10...

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PUM

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Abstract

The invention discloses a spiderflower seed oil suppository and a preparation method thereof. The spiderflower seed oil suppository disclosed by the invention is composed of the following components in parts by weight: 1-3 parts of spiderflower seed oil, 7-9 parts of matrix and 0.1-1 part of an absorption enhancer. The spiderflower seed oil suppository disclosed by the invention can directly act on anuses, and is capable of effectively increasing the bioavailability of spiderflower seed oil and treating haemorrhoids more effectively; simultaneously, found from searches, spiderflower seed volatile oil has the anti-inflammatory action, and thus, the spiderflower seed oil suppository disclosed by the invention is expected to be developed into a medicinal preparation for treating intestinal or vagina inflammation.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and mainly relates to a cauliflower oil suppository and a preparation method thereof. Background technique [0002] The cauliflower seed is the seed of the cauliflower genus of the cauliflower family, which is bitter, pungent, warm and slightly poisonous. "Compendium of Materia Medica" records: decoct water, wash hemorrhoids; mash, apply rheumatic arthralgia; brew wine and drink, stop malaria; "Anhui Medicinal Materials" records: disperse wind and dampness, promote blood circulation and relieve pain. As the main active ingredient of cauliflower seed, volatile oil has been found to have anti-inflammatory and analgesic effects. At present, cauliflower seed is mainly used internally (decoction) and external application (decoction and fumigation), because the main active ingredients that exert its external function are volatile oils. The utilization rate is not high. Contents of the inv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/02A61P9/14A61P29/00A61P15/02A61P1/00
CPCA61K9/0031A61K9/0034A61K9/02A61K36/185A61K47/10A61K47/12A61K47/20A61K47/26A61K47/42A61K2236/15A61K2236/331
Inventor 朱丽平陈建晖范超杰
Owner ZHENGZHOU HOUYI PHARMA
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