Method for preparing polymethacrylate/hydroxyapatite composite biological ceramic material

Abstract

The invention provides a method for preparing a polymethacrylate / hydroxyapatite composite biological ceramic material. The method comprises the following steps: (1) dissolving polymethacrylate, a surfactant and a cosurfactant into an organic solvent, so as to prepare an oil-phase solution of polymethacrylate; (2) respectively adding a calcium ion solution and a phosphate ion solution into the oil-phase solution, so as to prepare an emulsion and a phosphate ion emulsion, mixing the calcium ion emulsion and the phosphate ion emulsion, and reacting for 24-48 hours at the temperature of 40-80 DEG C, so as to form a polymethacrylate / hydroxyapatite mixed emulsion; (3) volatilizing the organic solvent in the mixed emulsion, washing with water, drying, so as to obtain powder, and sintering the obtained powder in a spark plasma sintering chamber. The composite biological ceramic material prepared by the method is good in dispersity, high in mechanical strength, relatively lower in reaction temperature, higher in bioavailability and safer in production, and hydroxyapatite cannot be degraded.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a method for preparing a polymethacrylate / hydroxyapatite composite bioceramic material. Background technique [0002] Bone defects have always been a medical problem. At present, the ideal method is autologous or allogeneic bone grafting, and autologous bone grafting is widely regarded as the "gold standard" for measuring bone graft fusion. Although autologous bone grafting has many advantages, such as adapting to the regeneration of surrounding bone tissue, there are still some disadvantages, such as limited donors for autologous bone grafting, secondary trauma, increased surgical difficulty, and a certain failure rate. Allograft bone sometimes cannot stimulate osteogenesis, and often induces adverse reactions. Research on new bone substitute products has become a common problem faced by medical workers and material workers. [0003] Hydroxyapatite is the main inorganic component o...

AI Technical Summary

Problems solved by technology

The melt blending method is simple and convenient to operate, but due to the certain viscosity of the polymer, it is difficult to fully disperse the filler particles inside the substrate, resulting in uneven particle distribution and low interface strength; the in-situ composite method can better improve the interface strength, but it is easy to Residual reaction impurities affect product performance; the solution casting method is to select a suitable solvent, add nano-inorganic particles to the polymer bulk solution, and remove the solvent after sufficient dispersion. The obtained composite material has good dispersion, but the relative density is low and the performance not guaranteed