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Bilirubin adsorbent for blood perfusion

A blood perfusion and adsorbent technology, applied in the field of adsorbents for bilirubin and bile acid, can solve the problems of electrolyte disturbance, increased medical expenses for patients, poor biocompatibility, etc., and achieves increased biocompatibility and excellent adsorption performance. , the effect of excellent blood compatibility

Active Publication Date: 2014-12-03
TIANJIN YOUNASI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of adsorbent can only be used for plasma perfusion, and its biocompatibility is poor, and there are problems such as electrolyte disturbance that need attention, and it also greatly increases the medical expenses of patients.
[0006] At present, there is no adsorbent product that can be used for whole blood perfusion and has an excellent scavenging effect on bilirubin.

Method used

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  • Bilirubin adsorbent for blood perfusion
  • Bilirubin adsorbent for blood perfusion
  • Bilirubin adsorbent for blood perfusion

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Example 1 Preparation of highly cross-linked macroporous microspheres

[0028] At room temperature, dissolve 10g of gelatin in 1000ml of water to make a 1.0% (mass fraction) aqueous solution, place it in a 2000ml three-necked flask and heat it to 45°C to fully dissolve the gelatin; mix 50g of styrene, 100g of divinylbenzene , 110g of toluene, 190g of liquid paraffin, 10g of oligostyrene (polymerization degree 1000) and 1.5g of azobisisobutylcyanide were mixed evenly and then added to the three-necked bottle, started to stir, and adjusted the speed to disperse the oil droplets into an appropriate size, and then suspended Polymerization, slowly heat up to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly heat up to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then heat up at a speed of 1-2°C / 5 minutes Slowly raise the temperature to above 95°C in 5 minutes, react for 5 hours, then stop the reaction, filter and wash to prepare Cross-linke...

Embodiment 2

[0030] Example 2 Preparation of highly cross-linked macroporous microspheres

[0031] At room temperature, dissolve 18g of polyvinyl alcohol in 1200ml of water to make a 1.5% (mass fraction) aqueous solution, place it in a 3000ml three-neck bottle and heat it to 45°C to fully dissolve the polyvinyl alcohol; 25g of styrene, 125g Divinylbenzene, 20g of oligomeric methacrylates, 80g of toluene, 25g of liquid paraffin, 25g of solid paraffin and 2.0g of benzoyl peroxide were evenly mixed and then added to the three-necked bottle, started stirring, and adjusted the speed to disperse the oil droplets. After suspension polymerization, slowly heat up to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly heat up to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then react for 1-2 °C / 5 minutes to slowly raise the temperature to above 95 °C, react for 5 hours, then stop the reaction, filter and wash to prepare high Cross-linked polystyrene-divinylbenzene ma...

Embodiment 3

[0033] Example 3 Preparation of highly cross-linked ultra-macroporous microspheres

[0034] At room temperature, dissolve 20g of polyvinyl alcohol in 1000ml of water to make a 2.0% (mass fraction) aqueous solution, place it in a 2000ml three-necked bottle and heat it to 45°C to fully dissolve the polyvinyl alcohol; dissolve 150g of divinylbenzene , 200g of toluene, 190g of solid paraffin, 15g of polyvinyl acetate (polymerization degree 500) and 1.5g of benzoyl peroxide were mixed evenly and then added to the three-necked bottle, started to stir, and adjusted the speed to disperse the oil droplets into an appropriate size, and then suspended polymerization , Slowly raise the temperature to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly raise the temperature to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then react at a speed of 1-2°C / 5 Slowly heat up to above 95°C at a speed of 1 minute, react for 5 hours, then stop the reaction, filter and ...

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Abstract

The invention relates to a bilirubin adsorbent for blood perfusion. The bilirubin adsorbent is based on a molecular imprinting principle, oligomeric macromolecules and the like which have the molecular weight similar to that of human serum albumin are taken as pore-foaming agents, polystyrene-divinyl benzene is taken as a basic framework, and the bilirubin adsorbent with oversized aperture and high specific surface area is prepared according to a free radical suspension polymerization method. The bilirubin adsorbent not only has ultrahigh specific surface area, but also has a pore passage suitable for the free diffusion of bilirubin conjugated with albumin, and has a good adsorbing effect on the conjugated and non-conjugated bilirubin. Furthermore, compared with the traditional bilirubin adsorbent, the bilirubin adsorbent for blood perfusion has the characteristics of being simple in preparation technology, good in biocompatibility, large in adsorption capacity, and free from risk of electrolyte disorder, thus being not only used for plasma perfusion, but also used for removing the bilirubin by all-blood perfusion.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a novel medical adsorbent, in particular to an adsorbent suitable for removing excessively high bilirubin and bile acid in blood through extracorporeal blood perfusion. Background technique [0002] Bilirubin (Bilirubin BR) is one of the main pigments of bile, which is produced by aging red blood cells and excreted mainly after metabolism by the liver. If there is too much bilirubin in the body, or the liver's uptake, metabolism or excretion of bilirubin is impaired, bilirubin will accumulate in the body, resulting in bilirubinemia. Free bilirubin is an endogenous toxin. Its lipophilicity makes it easy to pass through biological membranes and deposit in tissues, causing yellow staining of sclera and skin. When the concentration of unconjugated bilirubin in plasma exceeds 20-25mg / dl, it can pass through the blood-brain barrier and combine with nerve nuclei, interfere with the f...

Claims

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Application Information

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IPC IPC(8): B01J20/26A61M1/14
Inventor 欧来良俞耀庭陈建王为超
Owner TIANJIN YOUNASI BIOTECH
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