Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing granisetron hydrochloride and preparation thereof

A technology of granisetron hydrochloride and composition, which is applied in the field of pharmaceutical compositions containing granisetron hydrochloride and its preparation, can solve the problems of unsustainable curative effect, reduced adverse drug reactions, large adverse reactions, etc. Hepatic damaging effect and effect of improving medication compliance

Active Publication Date: 2014-10-15
CHINA NAT MEDICINES GUORUI PHARMA
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the technical deficiencies in the prior art that the adverse reactions in the antiemetic treatment process in the clinical cancer treatment process are large and the curative effect is difficult to sustain, the present invention provides a pharmaceutical composition for antiemetic, which is composed of granisetron hydrochloride and Sulfin is the active ingredient of the drug. When the pharmaceutical composition is used for antiemetic treatment, the two active components have a significant synergistic effect on the antiemetic aspect, and can significantly reduce the adverse reactions of the drug, especially showing a significant effect on the liver. Protective effect, so it is suitable to be developed into a clinical therapeutic drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing granisetron hydrochloride and preparation thereof
  • Pharmaceutical composition containing granisetron hydrochloride and preparation thereof
  • Pharmaceutical composition containing granisetron hydrochloride and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The freeze-dried powder injection of embodiment 1 pharmaceutical composition of the present invention

[0022] Prescription composition:

[0023]

[0024] Preparation process: Weigh granisetron hydrochloride, draconidin and mannitol respectively according to the prescription amount. Add mannitol to an appropriate amount of water for injection, stir to dissolve and adsorb with 0.1% (w / v) activated carbon, pre-filter with a 0.45 μm filter or filter membrane, add granisetron hydrochloride, stir to dissolve and adjust the pH value to 7.0-8.5 with sodium hydroxide After pre-filtering with a 0.45 μm filter or membrane, constant volume, 0.45 μm and 0.22 μm filter or filter membrane for sterilization and filtration, filling, semi-tamponing, and freeze-drying can obtain the lyophilized powder injection of the composition of the present invention.

Embodiment 2

[0025] The freeze-dried powder injection of embodiment 2 pharmaceutical composition of the present invention

[0026] Prescription composition:

[0027]

[0028] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

Embodiment 3

[0029] The freeze-dried powder injection of embodiment 3 pharmaceutical composition of the present invention

[0030] Prescription composition:

[0031]

[0032] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention particularly relates to a pharmaceutical composition containing granisetron hydrochloride and a freeze-dried powder injection thereof and belongs to the field of medicine. The granisetron hydrochloride enables the liver transaminase content to be increased during nausea and vomiting in the treatment, radiotherapy and chemotherapy process and accordingly influences the treatment effect on nausea and vomiting. For overcoming the technical shortcomings, the invention provides a pharmaceutical composition containing the granisetron hydrochloride. An applicant prepares the pharmaceutical composition into the freeze-dried powder injection through reasonable compatibility and finds that the pharmaceutical composition has good treatment effect on nausea and vomiting in the treatment, radiotherapy and chemotherapy process when applying the freeze-dried powder injection to vomiting-stopping treatment, the adverse medicine effect can be remarkably reduced, and the pharmaceutical composition especially has remarkable protection effect on the liver and therefore is suitable for development of clinic treatment medicine.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing granisetron hydrochloride and a preparation thereof, in particular to a lyophilized powder injection containing granisetron hydrochloride and fenaurolactin as pharmaceutical active ingredients, belonging to the field of medicine. Background technique [0002] Vomiting is a manifestation of the strong contraction of the stomach forcing the contents of the stomach or part of the small intestine out of the body through the esophagus and oral cavity. The process can be divided into 3 stages, namely nausea, retching and vomiting. During nausea, the upper part of the stomach relaxes and the gastric antrum contracts briefly; during vomiting, the gastric antrum continues to contract, the cardia opens, the abdominal muscles contract, and the abdominal pressure increases, forcing the gastric contents to quickly and violently reflux from the stomach and be discharged through the esophagus and oral c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/08A61P1/16A61P11/00A61K31/439
Inventor 王健蒋敏吴洁王旭王磊姚磊刘家玉
Owner CHINA NAT MEDICINES GUORUI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com