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Use of Liushen pills in preparing medicines for preventing and treating dermatomycoses

A technology of fungal skin diseases and Liushen Pills, which is applied in the application field of Liushen Pills and its external preparations in the preparation of drugs for treating fungal skin diseases. Sexuality, toxic and side effects and other problems, to achieve the effect of not easy to relapse, good clinical application prospects, and no drug resistance

Active Publication Date: 2014-09-17
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of such diseases is mainly based on external medicines, such as miconazole nitrate, ketoconazole, clotrimazole, etc. Most of the patients have produced good curative effect through use, but these drugs have the following disadvantages: such as long course of treatment, It can range from ten days to several months; long-term use has serious side effects; drug resistance is easy to develop; the recurrence rate is high after drug withdrawal

Method used

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  • Use of Liushen pills in preparing medicines for preventing and treating dermatomycoses
  • Use of Liushen pills in preparing medicines for preventing and treating dermatomycoses
  • Use of Liushen pills in preparing medicines for preventing and treating dermatomycoses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 6

[0017] Example 1 Study on Antifungal Pharmacodynamics of Liushen Pills

[0018] 1. Materials

[0019] 1.1 Drugs

[0020] Liushen Pill Suspension: Liushen Pill (produced by Leiyunshang Pharmaceutical Co., Ltd.) is ground and added with different amounts of distilled water to make high concentration (3mg / ml), medium (1.5mg / ml), low concentration (0.75mg / ml) ) of the Liushen Pill suspension. Positive control drug: dacryline cream. Negative control drug: cream base.

[0021] 1.2 Strains

[0022] Trichophyton rubrum, Trichophyton gypsum, Epidermophyton flocculum, Microsporum canis, Candida albicans.

[0023] 1.3 Medium

[0024] Sabouraud's Modified Medium

[0025] 1.4 Test animals

[0026] White guinea pig 350g±10g, male

[0027] 1.5 Data processing

[0028] SPSS16.0 software was used for statistical analysis. Measurement data are expressed as mean ± standard deviation Indicates that the comparison between groups was performed by analysis of variance.

[0029] 2. Meth...

Embodiment 2 6

[0044] Example 2 Clinical Observation on Treatment of Athlete's Foot by Liushen Gel

[0045] 1 Materials and methods

[0046] 1.1 Clinical data

[0047] 210 cases of tinea pedis patients, according to the typical clinical symptoms and signs of the patients, and fungal microscopic examination positive cases of fungal infection of the foot, aged (24-55) years, gender is not limited, the course of disease is 14 days to 5 years, all patients adopt They were divided into treatment group and control group by random number table method, with 105 cases in each group. The general conditions, age, occupation, and physical condition of the two groups were balanced and comparable. Diagnostic criteria for tinea pedis: ①Inducement: the feet are prone to sweating, and the shoes are not breathable; ②Clinical manifestations: foot itching, desquamation and blisters, often secondary to bacterial infection due to scratching and friction; ③Fungus microscopic examination is positive. Exclusion cr...

Embodiment 3 6

[0061] Example 3 Liushen Ointment Treatment of tinea corporis Clinical Observation

[0062] 1 Materials and methods

[0063] 1.1 Clinical data

[0064] A total of 176 patients with skin diseases, clinical rash performance in line with the typical clinical features of tinea corporis, and fungal picture examination was positive, in line with the diagnostic criteria for tinea corporis. Among them, there were 106 males and 70 females; their age ranged from 22 to 67 years, with an average of 35.2 years, and the course of the disease ranged from 5 months to 5 years, with an average of 3.4 years. The patients were randomly divided into two groups, 88 cases in the treatment group and 88 cases in the control group. There was no significant difference between the two groups in terms of age, sex, course of disease, and severity of rash after statistical processing, and they were comparable. All patients did not use external antifungal and glucocorticoid hormone preparations within 4 we...

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Abstract

The invention discloses a new use of Liushen pills in preparing medicines for preventing and treating dermatomycoses. Pharmacodynamics study on fungal resistance of Liushen pills is carried out by use of lots of experiments and results indicate that the Liushen pills have inhibiting effect on all common skin pathomycete and obvious itching relieving effect. Besides, clinical study on treating tinea pedis, tinea corporis and tinea cruris by use of the Liushen pills is still carried out and results indicate that the Liushen pills have excellent treatment effect on the dermatomycoses such as the tinea pedis, the tinea corporis and the tinea cruris. Due to the use of the Liushen pills in treating the dermatomycoses, the uses of Chinese patent medicines are expanded, and the Liushen pills have the advantages of good curative effect, no drug resistance, no easy relapse and the like, and thus have excellent clinical use prospect.

Description

technical field [0001] The invention belongs to the new application of traditional Chinese medicine preparations, and specifically relates to the application of Liushen Pills and its external preparations in the preparation of medicines for treating fungal skin diseases. Background technique [0002] Fungal skin disease, also known as dermatophytosis, is an infection caused by superficial fungi invading human skin, hair, and deck, referred to as ringworm. Among them, dermatophytes are the main pathogenic bacteria of fungal skin diseases, mainly including Trichophyton, Microsporum and Epidermophyton. Common species are Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton flocculum. Divided into tinea capitis, tinea corporis, jock itch, tinea manuum, tinea pedis, etc. according to different parts of the disease. Tinea capitis is a dermatophytosis of the hair follicles of the scalp, clinically manifested by alopecia and scaling and often with an inflammatory r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K36/00A61K9/20A61P17/00A61P31/10
Inventor 李全王恒斌罗年翠王亦周
Owner 雷允上药业集团有限公司
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