Preparation method and application of pseudolarix lactone H

Abstract

The invention discloses an application of pseudolarix lactone H in pseudolarix seeds in preparation of functional foods and medicines for treating diabetes. The pseudolarix lactone H is prepared by the following methods: grinding the pseudolarix seeds, extracting by using a solvent A, extracting the filter residue by using a solvent B, concentrating and drying the extracting solution extracted twice, and merging to obtain a total crude extract; dispersing the total crude extract in an aqueous solution of low alcohols, extracting and degreasing by using petroleum ether, removing the petroleum ether phase, concentrating and drying the raffinate, and thus obtaining a triterpene extract of the pseudolarix seeds; and further taking a mixed solution of halomethane and acetone as a solvent, recrystallizing the triterpene extract, and thus obtaining the pseudolarix lactone H. The preparation method is simple in process, convenient in operation and low in energy consumption and is suitable for extracting and producing the pseudolarix lactone H from the pseudolarix seeds in a large scale.

Description

(1) Technical field [0001] The invention relates to the application of pseudolarolide H (pseudolarolide H), a component in pine seeds, in the preparation of functional food and medicine for treating diabetes, and a preparation method of pseudolarolide H, belonging to the technical field of medicine. (2) Background technology [0002] With the rapid development of the world economy and the aging of the population, diabetes mellitus (Diatetes mellitus) has become an epidemic non-communicable disease that has ravaged the world. It is one of the three major diseases in the world together with cancer and cardiovascular disease. Diabetes mellitus is an endocrine and metabolic disorder mainly manifested by glucose metabolism disorder. It is a group of metabolic diseases characterized by hyperglycemic metabolism due to defects in insulin secretion, or insulin action, or both. Chronic hyperglycemia in diabetes brings about increased oxidative stress, causing long-term damage to mult...

AI Technical Summary

Problems solved by technology

Western medicine currently treats diabetes oral drugs mainly include: sulfonylureas (such as glimepiride), biguanides (such as metformin), etc., most of them are synthetic drugs, which can promote insulin secretion, reduce the output of liver glycogen or increase Sensitivity to insulin, but it is easy to cause hypoglycemia or lactic acidosis, and cannot fundamentally prevent further necrosis of islet β cells, leading to insulin dependence

With the in-depth research on the basic theory of diabetes, the research on new diabetes drugs with other mechanisms of action has made progress, and many of them have been applied clinically: α-glucosidase inhibitors (such as acarbose), which can inhibit intestinal The α-glucosidase in the upper part blocks the decomposition of carbohydrates and enters the middle and lower parts of the small intestine for further decomposition and absorption, so that blood sugar can be maintained at a stable level and relieve the rise in blood sugar after meals, but this type of drug will cause abdominal discomfort and flatulence Other gastrointestinal adverse reactions

Aldose reductase inhibitors (such as epalrestat) can prevent and delay diabetic complications by inhibiting the polyalcohol metabolism pathway, but these drugs have relatively large toxic and side effects and unsatisfactory curative effects, which greatly limit their use. application

In addition, there are gluconeogenesis inhibitors, insulin sensitizers, etc., and the scope of application is not very wide.

Images