Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process for producing memantine hydrochloride

A memantine hydrochloride and production process technology, applied in the field of medicine, can solve the problems of low final yield, achieve the effect of avoiding the influence of yield, reducing side reactions, and improving product yield

Active Publication Date: 2014-08-06
CHENGDU YILUKANG MEDICAL TECH & SERVICE
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method has simple process, little harm to human body, and no pollution to the environment; but the final yield of the above method product is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Acetamidolation of 1-bromo-3,5-dimethyladamantane with acetonitrile under the action of concentrated sulfuric acid

[0031] The details are as follows: In a 500ml reaction flask, add 36.5g of 1-bromo-3,5-dimethyladamantane (0.15mol) and 105.75g of acetonitrile, then slowly add 280ml of concentrated Sulfuric acid (97%), stirred. Control the reaction temperature at 5°C; stir at room temperature for 12 hours after dropping, then pour the reaction solution into ice water and let it stand for 10 hours, a white precipitate precipitates; filter with suction and dry the filter cake to obtain 1-acetylamino-3, The crude product of 5-dimethyladamantane was 32.49g, and the yield was 97.73%.

Embodiment 2

[0033] 1-Acetamido-3,5-dimethyl hydrolysis under basic conditions to give 1-amino-3,5-dimethyladamantane

[0034] The details are as follows: In a 500ml reaction flask, add 22.1g (0.1mol) of 1-acetylamino-3,5-dimethyladamantane prepared as described in Example 1, 20.1g of ethylene glycol, and 20g of hydrogen Sodium oxide and 55ml of water, slowly warm up and stir to dissolve the sodium hydroxide; control the temperature to 150°C and stir for 12 hours; stop stirring, cool the reaction solution to room temperature and transfer it to ice water, stir well, and let it stand for 1 hour. The oily matter precipitated; repeated extraction with 50ml of petroleum ether for 3 times, combined the petroleum ether layers for 3 times, dried the petroleum ether layer with anhydrous sodium sulfate, and then evaporated the petroleum ether to obtain a light yellow oily liquid which is 1-amino- 3,5-Dimethyladamantane.

Embodiment 3

[0036] 1-amino-3,5-dimethyladamantane was acidified to obtain memantine hydrochloride

[0037] Specifically as follows: get the oil prepared in Example 2, pass through dry hydrogen chloride, white solids are separated out, stop flowing hydrogen chloride gas when the solution pH=6, and the separated white solids are sucked and dried to obtain 19.93 g of memantine hydrochloride crude product, Yield 92.37% (Note: combined with the comprehensive yield of Examples 2 and 3).

[0038] Purification: recrystallized twice with chloroform to obtain 18.84g of the product, with a yield of 87.32% (note: combine the comprehensive yields of Examples 2 and 3).

[0039] The memantine hydrochloride prepared by the continuous process of the above-mentioned examples 1-3 has a comprehensive yield of the final product of 85.33%, which is far higher than the final product yield of the memantine hydrochloride prepared in the prior art Chinese patent CN 1335299 A embodiment 1 79%. The production proc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and in particular relates to a process for producing memantine hydrochloride. The process for producing the memantine hydrochloride comprises the steps of performing acetyl amination reaction on 1-bromo-3,5-dimethyladamantane and acetonitrile at 5-10 DEG C under the action of concentrated sulfuric acid to obtain 1-acetamino-3,5-dimethyladamantane; performing hydrolysis reaction on the 1-acetamino-3,5-dimethyladamantane and polyol which does not contain an ether bond under an alkali condition to obtain 1-amino-3,5-dimethyladamantane; and acidifying the 1-amino-3,5-dimethyladamantane with hydrochloric acid, and performing re-crystallization to obtain the high-purity memantine hydrochloride. The process for producing the memantine hydrochloride, disclosed by the invention, has the advantage that the product yield of the memantine hydrochloride is increased by controlling process parameters and changing process conditions based on an existing synthetic process.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a production process of memantine hydrochloride. Background technique [0002] Memantine hydrochloride (memantine hydrochloride), also known as 1,3-dimethyl-5-aminoadamantane hydrochloride, memantine hydrochloride, memantine hydrochloride, is a new type of anti-senile dementia drug, the first by German Merz company developed and marketed in Germany in 1984 under the trade name of Akatinol Memantine??, including regular tablets, capsules, and oral liquids. And in February 2002 and October 2003, it was approved to go on the market in Europe and the United States. Its chemical name is: 1-amino-3,5-dimethyladamantane hydrochloride, which is a non-competitive, moderately strong and fast voltage-gated N-methyl-D-aspartic acid (NMDA ) receptor antagonist, which can prevent the overload of intracellular calcium and inhibit the excitotoxicity of excitatory amino acids. It has good cura...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C211/38C07C209/00C07C209/62
Inventor 彭超
Owner CHENGDU YILUKANG MEDICAL TECH & SERVICE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com