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Triamcinolone acetonide acetat and preparation method thereof

A technology of cream and curmi, applied in the field of new curmi cream and its preparation, can solve the problems of uneven distribution of main ingredients, easy instability of cream, loss of effectiveness of cream, etc., to achieve industrial application, The preparation method is simple and easy to control, and the effect of anti-allergy is rapid

Active Publication Date: 2014-07-23
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are following problems in the new emulsifiable paste of the prior art: because this emulsifiable paste is formed by water phase, oily phase and emulsifier, emulsifiable paste is easily unstable after long-term placement, and emulsifiable paste loses effectiveness easily because of oil-water separation; The medicinal ingredients are unevenly distributed in the cream, making the medicinal effect unstable

Method used

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  • Triamcinolone acetonide acetat and preparation method thereof
  • Triamcinolone acetonide acetat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of curmixin emulsifiable paste is obtained by the preparation method of the following steps, and its preparation process schematic diagram is as follows: figure 1 Shown:

[0035] (1) Prepare each batch of raw materials according to the following prescription, the total weight of each batch is 400kg: triamcinolone acetonide acetate 0.4kg, miconazole nitrate 4kg, neomycin sulfate 1.2 billion units, propylene glycol 19.2kg, polyethylene glycol-40028.8 kg, C16-18 alcohol 23kg, glyceryl monostearate 15.5kg, white petrolatum 3.0kg, stearic acid 3.8kg, isopropyl myristate 19.2kg, Pingpingjia-O 6.1kg, lavender essence 0.4kg, purified water balance;

[0036] (2) Preparation of main drug solution: propylene glycol, polyethylene glycol-400, triamcinolone acetonide acetate, and miconazole nitrate of the above prescription amount are put into an insulated mixing tank, heated in a water bath, and constantly stirred to dissolve completely, Keep warm at 80±2°C for standby;

...

Embodiment 2

[0045] A kind of curmixin emulsifiable paste is obtained by the preparation method of the following steps, and its preparation process schematic diagram is as follows: figure 2 Shown:

[0046] (1) Prepare each batch of raw materials according to the following prescription, the total weight of each batch is 400kg: triamcinolone acetonide acetate 0.4kg, miconazole nitrate 4kg, neomycin sulfate 1.2 billion units, propylene glycol 19.2kg, polyethylene glycol-40028.8 kg, C16-18 alcohol 23kg, glyceryl monostearate 15.5kg, white petrolatum 3.0kg, stearic acid 3.8kg, isopropyl myristate 19.2kg, Pingpingjia-O 6.1kg, lavender essence 0.4kg, purified water balance;

[0047] (2) Preparation of the main drug solution: put propylene glycol, polyethylene glycol-400, triamcinolone acetonide, and miconazole nitrate in the above-mentioned prescription amount into an insulated stirring tank, heat in a water bath, and the temperature of the water bath is 80-85°C. Stir continuously to dissolve ...

Embodiment 3

[0057] A kind of curmixin emulsifiable paste is obtained by the preparation method of the following steps, and its preparation process schematic diagram is as follows: figure 2 Shown:

[0058] (1) Prepare each batch of raw materials according to the following prescription, the total weight of each batch is 400kg: triamcinolone acetonide acetate 0.4kg, miconazole nitrate 4kg, neomycin sulfate 1.2 billion units, propylene glycol 19.2kg, polyethylene glycol-40028.8 kg, C16-18 alcohol 23kg, glyceryl monostearate 15.5kg, white petrolatum 3.0kg, stearic acid 3.8kg, isopropyl myristate 19.2kg, Pingpingjia-O 6.1kg, lavender essence 0.4kg, purified water balance;

[0059] (2) Preparation of the main drug solution: put propylene glycol, polyethylene glycol-400, triamcinolone acetonide, and miconazole nitrate in the above-mentioned prescription amount into an insulated stirring tank, heat in a water bath, and the temperature of the water bath is 80-85°C. Stir continuously to dissolve ...

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Abstract

The invention relates to triamcinolone acetonide acetat and a preparation method thereof. The preparation method of the triamcinolone acetonide acetat disclosed by the invention comprises the following steps: preparing each batch of raw materials according to the prescription; preparing a main drug solution; preparing an aqueous solution; preparing an oil-phase solution; preparing triamcinolone acetonide acetat: pre-heating an emulsification tank to 50-60 DEG C, starting a vacuum pump, rapidly filtering an oil-phase solution, and sucking into the emulsification tank; starting a stirrer, rapidly sucking the filtered aqueous solution, keeping initial-emulsification temperature at 80-90 DEG C, and homogenizing for 5 minutes; sucking a main drug solution, keeping emulsification temperature at 80-85 DEG C, homogenizing for 8 minutes, stirring, emulsifying, cooling, adding lavender essence, after cooling to be below 40 DEG C, stopping, discharging to obtain triamcinolone acetonide acetat to be sub-packaged, and filling and sealing according to standards. The triamcinolone acetonide acetat prepared through the preparation method disclosed by the invention is high in stability, long in guarantee period, steady and uniform in quality, high in skin penetrability and more rapid in anti-inflammatory, antiallergic and itching-relieving effects; main drug components are uniformly distributed in the triamcinolone acetonide acetat; the preparation method is simple and easy to control, and therefore, the triamcinolone acetonide acetat and the preparation method thereof disclosed by the invention are applied to industrial application.

Description

technical field [0001] The present invention relates to a kind of medicine and the technical field of medicine manufacture, in particular to a kind of trimidesin cream and a preparation method thereof. Background technique [0002] Trimetine is a kind of dermatological medicine, which has significant curative effect on eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, jock itch and tinea manus and pedis. The common dosage form of trimezin is cream, which contains miconazole nitrate as a broad-spectrum antifungal drug, and also has antibacterial effect on some Gram-positive bacteria; triamcinolone acetonide acetate is a glucocorticoid drug, which has anti Inflammatory, anti-allergic and antipruritic effects; neomycin sulfate is effective against a variety of Gram-positive and negative bacteria. [0003] There are following problems in the new emulsifiable paste of prior art: because this emulsifiable paste is formed by water phase, oily phas...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K9/06A61K47/34A61P17/00A61P29/00A61P37/08A61P17/04A61P31/10A61P31/04A61K31/58A61K31/4174
Inventor 伍伟成
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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