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Film forming composition for producing soft starch material capsule and preparation method of film forming composition

A technology of starch materials and soft capsules, applied in the field of biomedicine, can solve the problems of unsatisfactory encapsulation performance, failure to meet pharmacopoeia, friability and long disintegration time limit, etc., and reduce interaction or other compatibility problems. , Eliminate modification or replacement, improve the effect of gel performance

Active Publication Date: 2014-07-02
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the above prior art still has the defects of friability and long disintegration time limit, and the packaging performance is not ideal, which cannot meet the requirements of the Pharmacopoeia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Party:

[0048] Hydroxypropyl wheat starch: 5 parts, 3.8% hydroxypropyl content

[0049] Water: 40 parts,

[0050] Production steps: Soak hydroxypropyl wheat starch in water at 23°C in a plastic tank for 1 hour to obtain liquid A, heat liquid A to raise the temperature, when the temperature rises to 60°C, keep stirring for 25-30 minutes, then continue to heat up to 90°C ℃, keep warm for 1h, then cool down, keep warm for 1h when the temperature drops to 55°C, let it stand for defoaming, and seal it for later use. Take an appropriate amount of the film-forming composition prepared through the above steps to obtain 1000 starch soft capsules through the rotary die method.

Embodiment 2

[0052] Party:

[0053] Hydroxypropyl cornstarch: 5 parts, 2.4% hydroxypropyl content

[0054] Water: 20 parts

[0055] Production steps: add hydroxypropyl cornstarch to water and soak in a glue tank at 25°C for 2 hours to obtain liquid A, heat up liquid A, when the temperature rises to 65°C, keep it warm and stir for 35 minutes, then continue to heat up to 95°C, Keep warm for 1.5h, then cool down, keep warm for 1h when the temperature is lowered to 60°C, let it stand for defoaming, and seal it for later use. Take an appropriate amount of the film-forming composition prepared through the above steps to obtain 1000 starch soft capsules through the rotary die method.

Embodiment 3

[0057] Party:

[0058] Hydroxypropyl tapioca starch: 5 parts, 5.4% hydroxypropyl content

[0059] Water: 40 parts

[0060] Vanillin: 0.15 parts

[0061] Pharmaceutical grade tartrazine: 0.06 parts

[0062] Production steps: Soak hydroxypropyl wheat starch in water at 25°C in a plastic tank for 1 hour to obtain liquid A, heat liquid A to raise the temperature, when the temperature rises to 60°C, keep it warm and stir for 30 minutes, then continue to heat up to 85°C, Keep it warm for 1.5 hours, then cool it down, keep it warm for 1 hour when the temperature drops to 50°C, let it stand for defoaming, and seal it for later use. Take an appropriate amount of the film-forming composition prepared through the above steps to obtain 1000 starch soft capsules through the rotary die method.

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PUM

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Abstract

The invention relates to a film forming composition for producing a soft starch material capsule and a preparation method of the film forming composition, and the soft starch material capsule prepared from the film forming composition. The composition is formed by hydroxypropyl starch and water which are in a certain proportion, wherein optionally, proper auxiliary materials such as an opacifying agent, a colorant and a flavouring agent which are used for improving the performance of the soft capsule can be added. The preparation method comprises the following steps: mixing the materials according to a certain sequence; and controllably heating the materials in a temperature rising manner so as to obtain the film forming composition. The film forming composition can be directly produced so as to obtain the soft starch material capsule by indiscriminately using a production method of the traditional soft gelatin capsule.

Description

technical field [0001] The invention discloses a composition for preparing starch material soft capsules, a preparation method thereof, and a starch-based soft capsule prepared by the composition, and relates to the field of biomedicine. Background technique [0002] Capsules are a kind of pharmaceutical dosage form of modern medicine with wide uses and varieties. Capsules are widely used by various medical research institutions and institutions because of their simple prescription research, short development cycle, simple preparation process, and easy preparation of sustained and controlled release dosage forms. Favored by pharmaceutical companies. [0003] The capsule shell of traditional capsules is made of gelatin. Gelatin is a non-biologically active collagen hydrolyzate obtained by boiling animal skin and bone. It swells in cold water and dissolves into a glue in hot water. For a long period of time, almost all capsule shells on the market are made of gelatin. Even t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/48
CPCA61K8/00A61K47/38A61K9/4816C08L3/08C08L5/00C08L5/06
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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