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Medicinal composition for treating hypertension and application thereof

A composition and technology for hypertension, applied in the field of traditional Chinese medicine pharmacy, can solve the problems of insignificant treatment effect, unclear mechanism of action, poor patient compliance, etc. Effect

Active Publication Date: 2014-07-02
XIZANG HANSES PHARMA DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing disclosed technology, the formula of pure Chinese medicine is mainly used for treatment. The prescription generally contains multi-flavored Chinese medicinal materials, and it is taken by decocting. Although it has a certain curative effect, it has slow onset and unclear mechanism of action. , The treatment effect is not obvious, the taste is bitter, the patient's compliance is poor, and some patients will have defects such as gastrointestinal discomfort

Method used

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  • Medicinal composition for treating hypertension and application thereof
  • Medicinal composition for treating hypertension and application thereof
  • Medicinal composition for treating hypertension and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0034] The preparation of the water-soluble extract of Tibetan Salvia miltiorrhiza: crush the authentic medicinal material Tibetan salvia miltiorrhiza, add water to extract after sieving; carry out alcohol precipitation treatment on the extract, filter and concentrate the alcohol solution; adjust the pH of the alcohol solution to 2.0, filter Remove the precipitate and take the supernatant; after purifying the supernatant by Sephadex resin, and eluting it with water and alcohol for 5 times respectively, the alcohol wash was collected and concentrated; the concentrate was at pH 8.0, Treat at 65°C for 1 hour, heat up to 80°C for 2 hours, then heat up to 100°C for 1 hour; adjust the pH of the system to 4.0, concentrate and dry.

[0035] The preparation method of the alcohol extract of Gastrodia elata is as follows: wash the dried authentic medicinal material Gastrodia elata, treat it with microwave or ultrasonic method for 8-10 minutes, break it, add water to refine it, and centrif...

Embodiment 1

[0037] Example 1 tablet

[0038] Take 100g of the dry extract of Tibetan Salvia miltiorrhiza, 70g of dry extract of Gastrodia elata, and 60g of dry extract of Eucommia ulmoides leaves prepared above, and evenly disperse them in 200g of corn oil, dry them in a low-temperature vacuum at 30°C, grind them into 200-mesh fine powder, and add 50g of lactose , 50g mannitol, 100g maltooligosaccharide, 0.2g stevioside were mixed and granulated, dried and whole granules were added with 4g magnesium stearate and mixed; tableting made 1000 tablets of preparation.

Embodiment 2

[0039] Example 2 dry suspension

[0040] Take 150g of the dry extract of Tibetan Salvia miltiorrhiza prepared above, 60g of dry extract of Gastrodia elata, and 100g of dry extract of Eucommia ulmoides leaves, and mix them evenly in 150g of olive oil. Prepare the dry powder, mix it with 100g hydroxypropyl methylcellulose, 200g microcrystalline cellulose, and 200g sucrose in a mixer; granulate; use 20ml of 50% ethanol to make a soft material, and make it with a 20-mesh nylon mesh Granules; dried, the whole grains are packaged into 1000 bags of dry suspension preparations.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a medicinal composition for treating hypertension and an application thereof. The medicinal composition comprises the following components by weight: 80-200g of red-rooted salvia root extract, 50-120g of tall gastrodia tuber extract, 40-200g of eucommia ulmoides leaf extract, 100-500g of natural dispersing agent and 10-50g of natural suspending agent. Through synergistic effect among various Chinese medicinal extracts, the medicinal value of each extract is increased, the dose of each Chinese medicinal extract for achieving the same medicinal effect is reduced, and the defects of a large number of taking forms, large dosage, slow response, gastrointestinal tract discomfort and the like in the conventional oral antihypertensive Chinese medicinal composition are overcome. Meanwhile, a special production process is adopted, and pure natural extracts such as the dispersing agent are taken as medicinal adjuvants, so that the mouthfeel of the medicine is improved. Compared with other products of the same type, the medicinal composition has the advantages of no bitterness and convenience in taking, and the compliance of patients is improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine extract pharmaceutical composition for lowering blood pressure, lowering blood fat, regulating heart function and anti-cardiocerebral ischemia and its application. Background technique [0002] Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension It is a common disease and frequently-occurring disease. Essential hypertension, also known as hypertension, is an independent disease with elevated blood pressure as the main clinical manifestation and the etiology is not clear, accounting for more than 90% of hypertensive patients. Secondary hypertension is also called symptomatic hypertension. In this category, the etiology o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A23L1/29A61K47/46A61K47/44A61K47/24A61P9/12A61P9/10A61P9/00A61P3/06A61P3/10A23L33/00
Inventor 钱陈钦
Owner XIZANG HANSES PHARMA DEV
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