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A kind of bioactive porous hybrid carbon nanofiber material and preparation method thereof

A technology of carbon nanofibers and bioactivity, which is applied in the fields of fiber chemical characteristics, rayon manufacturing, prosthesis, etc., can solve the application requirements that cannot meet the high bioactivity of carbon nanofibers, reduce the activity of bioactive particles, and the structure of pores is not easy Control and other issues to achieve excellent biological activity, accelerated release speed, and accelerated formation

Active Publication Date: 2016-05-11
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the hydrothermal activation method uses carbon dioxide, water vapor or a mixture of the two to treat carbon nanofibers at a certain temperature. The pores obtained by this method are mainly micropores, and the structure of the pores is not easy to control; the acid-base immersion method is mainly Use hydroxides, such as sodium hydroxide and potassium hydroxide, or acids, such as phosphoric acid, nitric acid and sulfuric acid, as activators to soak carbon nanofibers. Both methods reduce the activity of bioactive particles
The literature (Small, 2007,3(1):91–95) proposes to use polymethyl methacrylate as a porogen, and the literature (Journal of PolymerScience: Part B: PolymerPhysics, 2009,47:493–503) uses polylactic acid as a porogen In the two literatures, the blend spinning method was used to prepare porous carbon nanofibers, but the pre-oxidation, carbonization and other heat treatment stages used a one-step heating process, and the porous structure formed in the carbon nanofibers was irregular and the pore size was controllable. Poor performance, which cannot meet the application requirements of high bioactivity of carbon nanofibers in bone repair applications

Method used

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  • A kind of bioactive porous hybrid carbon nanofiber material and preparation method thereof
  • A kind of bioactive porous hybrid carbon nanofiber material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] Using calcium nitrate tetrahydrate as the calcium source, triethyl phosphate as the phosphorus source, and tetraethyl orthosilicate as the silicon source, the three are miscible to obtain a bioactive glass sol-gel solution, and its mass in the spinning solution The percentage is 5%. Polyacrylonitrile and polylactic acid are miscible in nitrogen-nitrogen dimethylformamide at a mass ratio of 2 / 1, and a uniform and stable solution is obtained by ultrasonication in a 70°C water bath, and then the bioactive glass sol-gel solution is added From the above solution, the spinning solution was prepared by ultrasonic aging for 4 days, and the nascent nanofiber membrane was prepared by electrospinning.

[0026] Cut the nascent nanofiber membrane to a suitable size, fix both ends with clamps, and apply a constant force at the lower end of the clamps, then hang it in a pre-oxidation furnace for thermal drawing and pre-oxidation process of heating up in stages, heating at 5°C / min Hea...

Embodiment 2

[0028]Calcium nitrate tetrahydrate was used as the calcium source, and triethyl phosphate was used as the phosphorus source. The α-tricalcium phosphate sol-gel solution was prepared by mixing the two, and its mass percentage in the spinning solution was 10%. Polyacrylonitrile and polylactic acid are miscible in nitrogen-nitrogen dimethylformamide at a mass ratio of 2 / 1, and a uniform and stable solution is obtained by ultrasonication in a water bath at 70°C, and then α-tricalcium phosphate sol-gel The solution was added to the above solution, and the spinning solution was prepared by ultrasonic aging for 4 days, and the primary nanofiber film was prepared by electrospinning.

[0029] Cut the nascent nanofiber membrane to a suitable size, fix both ends with clamps, and apply a constant force at the lower end of the clamps, then hang it in a pre-oxidation furnace for thermal drawing and pre-oxidation process of heating up in stages, heating at 5°C / min Heat at 100°C for 10 minute...

Embodiment 3

[0031] Calcium nitrate tetrahydrate was used as the calcium source, and triethyl phosphate was used as the phosphorus source, and the two were mixed to obtain a β-tricalcium phosphate sol-gel solution, and its mass percentage in the spinning solution was 8%. Polyacrylonitrile and polylactic acid are miscibly dissolved in nitrogen-nitrogen dimethylformamide at a mass ratio of 2 / 1, and a uniform and stable solution is obtained by ultrasonication in a water bath at 70°C, and then β-tricalcium phosphate sol-gel The solution was added to the above solution, and the spinning solution was prepared by ultrasonic aging for 5 days, and the nascent nanofiber membrane was prepared by electrospinning.

[0032] Cut the nascent nanofiber membrane to a suitable size, fix both ends with clamps, and apply a constant force at the lower end of the clamps, then hang it in a pre-oxidation furnace for thermal drawing and pre-oxidation process of heating up in stages, heating at 5°C / min Heat at 100°C...

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Abstract

The invention provides a bioactive porous hybrid carbon nanofiber material and a preparation method thereof, and belongs to the technical field of biological composite materials. The bioactive porous hybrid carbon nanofiber material is prepared by virtue of a process comprising the steps of evenly mixing a precursor sol-gel liquid of a bioactive substance, polyacrylonitrile, a pore-foaming agent and an organic solvent together under the conditions of heating in a water bath and ultrasonics, aging to obtain a spinning solution, forming a primary nanofiber film by virtue of an electrostatic spinning process, and then carrying out hot-stretching, pre-oxidating in heating stage by stage and carbonizing, and a preparation method of the bioactive porous hybrid carbon nanofiber material. Due to the bioactive nanoparticles existing on the surface of the material, the material has biocompatibility, bioactivity and biodegradability; due to existing regular-structure nano-scale pores, the material has the relatively high specific surface area, and therefore, the biological properties of the material are greatly improved. As a result, the bioactive porous hybrid carbon nanofiber material can be further used as a novel bone repair material or a bone tissue scaffold reinforcing material.

Description

technical field [0001] The invention belongs to the technical field of biological composite materials, in particular to a porous hybrid carbon nanofiber material with biological activity and a preparation method thereof, which can be used as a bone repair material with biological activity, biocompatibility and biodegradability. Background technique [0002] In recent years, carbon nanofibers (CNFs) have been widely used in the field of bone repair materials or bone tissue scaffold reinforcement materials due to their excellent mechanical properties, chemical stability, hemocompatibility, biological compatibility and high specific surface area. However, since the continuous length of carbon nanofibers cannot be degraded and excreted in the human body through biodissolution, aerobic biooxidation, phagocytosis, or excretion, its wide-scale application is greatly limited. In order to solve this problem, people have endowed carbon nanofibers with degradability and disintegration ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F9/22D01F1/10A61L27/40A61L27/56A61L27/54A61L27/58
Inventor 贾晓龙张翠华杨小平蔡晴唐天洪程丹
Owner BEIJING UNIV OF CHEM TECH
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