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Calcium borate silicate biological material as well as preparation and application thereof

A biomaterial, calcium borosilicate technology, applied in dental preparations, dental prostheses, compression molding cups, etc., to achieve the effect of easy operation, low price, and simple preparation process

Active Publication Date: 2014-05-28
安徽(淮北)新型煤化工合成材料基地管理委员会科技服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, pure phase calcium borosilicate ceramic materials and preparation methods thereof, especially pure phase calcium borosilicate Ca 11 Si 4 B 2 o 22 Ceramic materials have not been reported as biomaterials

Method used

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  • Calcium borate silicate biological material as well as preparation and application thereof
  • Calcium borate silicate biological material as well as preparation and application thereof
  • Calcium borate silicate biological material as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Preparation of Ca 11 Si 4 B 2 o 22

[0042] According to the chemical formula Ca 11 Si 4 B 2 o 22 , respectively weighed calcium carbonate CaCO 3 : 2.75 g, silicon dioxide SiO 2 : 0.609 g, boric acid H 3 BO 3 : 0.3092 g, after grinding and mixing in an agate mortar, select the air atmosphere for the first calcination, the temperature is 350 ℃, the calcination time is 3 hours, then cool to room temperature, take out the sample; the raw material calcined for the first time is fully Mix and grind evenly, then calcinate again in the air atmosphere, the temperature is 850 ° C, the calcining time is 9 hours, then cool to room temperature, take out the sample; finally it is fully ground again and calcined in the air in the muffle furnace, the calcining temperature is 1450 ℃, the calcination time is 15 hours, and the powdered Ca 11 Si 4 B 2 o 22 . The resulting powdered Ca 11 Si 4 B 2 o 22 Soak in simulated body fluid (SBF) for mineralization, ...

Embodiment 2

[0050] Embodiment 2: preparation Ca 11 Si 4 B 2 o 22

[0051] According to the chemical formula Ca 11 Si 4 B 2 o 22 , respectively weigh calcium oxide CaO: 2.0563 grams, silicon dioxide SiO 2 : 0.812 g, boron trioxide B 2 o 3 : 0.2321 g, after grinding and mixing in an agate mortar, select the air atmosphere for the first calcination, the temperature is 400 ° C, the calcination time is 4 hours, then cool to room temperature, take out the sample; the raw material for the first calcination is fully Mix and grind evenly, then calcinate again in the air atmosphere, the temperature is 900°C, the calcining time is 8 hours, then cool to room temperature, take out the sample; finally it is fully ground again and placed in the muffle furnace for air calcining, the calcining temperature is 1400°C, The calcination time is 14 hours, and the powdered Ca 11 Si 4 B 2 o 22 . The resulting powdered Ca 11 Si 4 B 2 o 22 Soak in simulated body fluid (SBF) for mineralization, ob...

Embodiment 3

[0053] Embodiment 3: preparation Ca 11 Si 4 B 2 o 22

[0054] According to the chemical formula Ca 11 Si 4 B 2 o 22 , weigh calcium hydroxide Ca(OH) 2 : 2.7167 g, silicon dioxide SiO 2 : 0.812 g, boric acid H 3 BO 3 : 0.4122 g, after grinding and mixing in an agate mortar, select the air atmosphere for the first calcination, the temperature is 450 ℃, the calcination time is 5 hours, then cool to room temperature, take out the sample; the raw material calcined for the first time is fully Mix and grind evenly, then calcinate again in the air atmosphere, the temperature is 800°C, the calcining time is 7 hours, then cool to room temperature, take out the sample; finally it is fully ground again and placed in the muffle furnace for air calcining, the calcining temperature is 1350°C, The calcination time is 13 hours, and the powdered Ca 11 Si 4 B 2 o 22 . The resulting powdered Ca 11 Si 4 B 2 o 22 Soak in simulated body fluid (SBF) for mineralization, observe the...

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Abstract

The invention relates to a calcium borate silicate biological material as well as preparation method and application thereof. Pure-phase calcium borate silicate Ca11Si4B2O22 powder is synthesized by a solid-phase synthesis method or a wet chemical synthesis method; the calcium borate silicate powder is pressed and moulded to obtain a calcium borate silicate ceramic block; the calcium borate silicate powder or the calcium borate silicate ceramic block is soaked in a simulated body fluid (SBF) for certain time and mineralized; after a while, a bone-like apatite layer can deposit on the surface of the powder or the ceramic block; researches find that the thickness of mineralized hydroxyapatite increases along with the increase of the soaking time. The calcium borate silicate powder or the ceramic material prepared through the preparation method has good biological performance, is a biological and medical material with very high potential, and can be used as a bone tissue repairing and filling material and a tooth repairing material.

Description

technical field [0001] The present invention relates to calcium borosilicate biomaterials, preparation methods and applications thereof, in particular to a biomineralization material capable of adsorbing hydroxyapatite (HAP) and inducing remineralization of hydroxyapatite and a preparation method thereof It belongs to the interdisciplinary field of material science, bionics and biomedicine. It involves a method that simulates the internal environment of the human body. The biomineralization method is used to spontaneously deposit hydroxyapatite in aqueous solution. The obtained coating not only has good Biological activity, but also can significantly improve the binding force of the coating. Background technique [0002] With the improvement of people's awareness of oral health, the demand for clinical technology to treat dental diseases caused by demineralization has increased rapidly. Organic matrices such as enamel matrix protein and dentin phosphoprotein in the human bo...

Claims

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Application Information

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IPC IPC(8): C04B35/22C04B35/622A61L27/10A61K6/02
Inventor 黄彦林王婧祁淑云魏东磊
Owner 安徽(淮北)新型煤化工合成材料基地管理委员会科技服务中心
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