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Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application

A technology of multivesicular liposomes and tea polyphenols, applied in the chemical field, can solve the problems of hard outer wall, small microcapsule particle size, and poor air permeability, and achieve the effects of strong air permeability, increased stability, and large surface area

Inactive Publication Date: 2014-05-28
SOUTH CHINA AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microcapsules have small particle size, hard outer wall and poor air permeability, so they are not suitable for use in cigarette filters
[0010] The research of processing these free radical scavengers into multivesicular liposomes and putting them into cigarette filters to scavenge gaseous free radicals (reduced radicals) has not been reported so far, let alone a synergistic composition based on squalene and tea polyphenols. Preparation technology and application report of multivesicular liposome

Method used

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  • Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application
  • Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application
  • Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Prepare each component according to the following parts by mass: 20 grams (g) of hydrogenated lecithin; squalene (Shanghai Xinran Biotechnology Co., Ltd., with a content greater than 96.0%, the same as the following examples. But this does not limit the present invention, Those skilled in the art can use 5 grams (g) of squalene from other sources; Tea polyphenols (Ningbo Youjie Chemical Co., Ltd., content greater than 98.0%, the same as the following examples. But this does not limit the present invention, the present invention Those skilled in the art can use 40 grams (g) of tea polyphenols from other sources; 15 grams (g) of oleic acid; 20 grams (g) of hydroxyethyl starch.

[0052] The preparation steps are:

[0053] S1. Dissolve hydrogenated phospholipids, squalene and tea polyphenols in 100mL propylene glycol to obtain a mixed system;

[0054] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of oleic acid, homogenize at a high speed ...

Embodiment 2

[0059] Each component was prepared according to the following parts by mass: 15 grams of hydrogenated soybean lecithin; 10 grams of squalene; 35 grams of tea polyphenols; 15 grams of glycerin;

[0060] The preparation steps are:

[0061] S1. Dissolve hydrogenated soybean lecithin, squalene and tea polyphenols in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0062] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of glycerin, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0063] S3. Add hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0064] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and tea polyphenols.

Embodiment 3

[0066] Each component was prepared according to the following parts by mass: 20 grams of hydrogenated soybean lecithin; 20 grams of squalene; 25 grams of tea polyphenol; 15 grams of chitosan;

[0067] The preparation steps are:

[0068] S1. Dissolve hydrogenated soybean lecithin, squalene and tea polyphenols in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0069] S2. Transfer the mixed system obtained in S1 into 50mL water containing 15g chitosan, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0070] S3. Add hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0071] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and tea polyphenols.

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Abstract

The invention discloses a squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application. Multivesicular liposome comprises, by weight, 12-20 parts of hydrogenated phospholipid, 15-20 parts of stabilizer, 10-15 parts of surfactant and the balance of squalene and tea polyphenol composition. The multivesicular liposome is placed in cigarette filter tips made of cellulose acetate fibers during shaping of the cigarette filter tips. When a consumer smokes, smoke passes the multivesicular liposome, the antioxidant in the multivesicular liposome is in sufficient contact with mainstream smoke due to the fact that the multivesicular liposome is large in surface area, the gas-phase free radical can be effectively eliminated, and powerful technical support is provided for solve the problems of smoking and health.

Description

technical field [0001] The invention relates to the technical field of chemistry, and more specifically relates to a multivesicular liposome containing squalene and tea polyphenol composition, a preparation method thereof and an application in cigarette base reduction and harm reduction. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentration of free radicals to the human body have attracted widespread attention. Free radicals have the strongest effect on the body and are the most harmful. They can cause lung disease, heart disease and cancer. These free radicals can cause serious damage to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbons free radicals, and reactive oxygen free radicals produced by their reactions with oxygen such as superoxide anion (O 2 - ), hydrogen peroxide (H 2...

Claims

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Application Information

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IPC IPC(8): A24D3/10
Inventor 江定心金亚波陈泽鹏韦建玉田君同李福君郑凤霞
Owner SOUTH CHINA AGRI UNIV
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