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Preparation method of liquid proliposome composed of squalene and astaxanthin and its application in base reduction and harm reduction

A technology of proliposome and astaxanthin, which is applied in the chemical field, can solve the problems of liquid proliposome preparation technology and application reports that have not been seen, and achieve the effects of large surface area, increased stability and large specific surface area

Inactive Publication Date: 2015-08-05
GUANGDONG BRANCH OF CHINA TOBACCO GENERAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There is no report on processing these free radical scavengers into liquid proliposomes and scientifically placing them in hookah cigarette holders to scavenge gaseous free radicals (reduced radicals), let alone studies based on the enhancement of squalene and astaxanthin. Preparation technology and application report of liquid proliposome with effective composition

Method used

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  • Preparation method of liquid proliposome composed of squalene and astaxanthin and its application in base reduction and harm reduction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Prepare each component according to the following parts by mass: 8 grams (g) of lecithin; Those skilled in the art can use 5 grams (g) of squalene from other sources; Those skilled in the art can use 10 grams (g) of astaxanthin from other sources); 8 grams (g) of glycerol; 8 grams (g) of hydroxymethyl starch, and 61 grams (g) of water.

[0050] The preparation steps are:

[0051] S1. Dissolving the composition of lecithin, squalene and astaxanthin in glycerol to obtain a mixed system;

[0052] S2. Homogenize the mixed system obtained in S1 at high speed to make it fully mixed to obtain a homogenized mixed system;

[0053] S3. Mix the stabilizer and water to obtain an aqueous solution of the stabilizer, add the aqueous solution of the stabilizer to the homogenized mixed system obtained in S2 and stir evenly to form a stable particle suspension to obtain the composition containing squalene and astaxanthin liquid proliposomes.

Embodiment 2

[0055] The preparation steps are the same as in Example 1. Weigh 8 grams of soybean lecithin, 10 grams of squalene, 5 grams of astaxanthin dissolved in 8 grams of glycerin, homogenize at a high speed to make it fully mixed, then add 8 grams of hydroxyethyl starch dissolved in 61 grams of water The aqueous solution is uniformly stirred to form a stable microparticle suspension, that is, the liquid proliposome containing the composition of antioxidant squalene and astaxanthin is obtained.

Embodiment 3

[0057] The preparation steps are the same as in Example 1. Weigh 10 grams of hydrogenated soybean lecithin, 5 grams of squalene, and 15 grams of astaxanthin dissolved in 10 grams of glycerol, homogenize at a high speed to fully mix, then add 10 grams of hydroxymethyl starch dissolved in 50 grams of water The aqueous solution is stirred evenly to form a stable microparticle suspension, that is, the liquid proliposome containing the antioxidant squalene and astaxanthin composition is obtained.

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Abstract

The invention discloses a preparation method of a squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of the squalene and astaxanthin composition liquid precursor lipidosome. The liquid precursor lipidosome is prepared by 8-12 parts of phospholipid, 8-15 parts of stabilizer, 8-15 parts of surfactant, 15-30 parts of squalene and astaxanthin composition and balance of water. The liquid precursor lipidosome is placed in a hollow cylinder provided with waterproof dustproof breathable films at two ends, the hollow cylinder is placed in a cigarette filter tip made of cellulose acetate fibers in the molding process of a cigarette filter tip bar, when a consumer smokes a cigarette, smoke passes by the internally arranged liquid precursor lipidosome, and an antioxidant is fully contacted with the mainstream smoke due to the large surface area of the liquid precursor lipidosome, so gas phase radicals in the mainstream smoke can be effectively cleared, and powerful technological support is provided for solving the problem that smoking is bad for health.

Description

technical field [0001] The invention relates to the technical field of chemistry, and more specifically relates to a liquid proliposome containing a composition of squalene and astaxanthin, a preparation method thereof, and an application in reducing bases and harms of hookah-type filters. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentration of free radicals to the human body have attracted widespread attention. Free radicals have the strongest effect on the body and are the most harmful. They can cause lung disease, heart disease and cancer. These free radicals can cause serious damage to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbons free radicals, and reactive oxygen free radicals produced by their reactions with oxygen such as superoxide anion (O 2 - ), hydrogen peroxide (H ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A24D3/14
Inventor 陈泽鹏江定心韦建玉王军朱文格林勇金亚波
Owner GUANGDONG BRANCH OF CHINA TOBACCO GENERAL
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