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Method and device to detect and treat diseases such as tumor or virus infection

A technology for tumors and tumor cells, which is applied in the field of tumor treatment and monitoring equipment, and can solve problems such as recurrence and metastasis, low immunity, and easy recurrence of tumor cells

Inactive Publication Date: 2014-04-16
王天欣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after surgery, long-term radiotherapy and chemotherapy, the body of tumor patients is greatly damaged, and their immunity is low. The remaining tumor cells are particularly prone to resurgence, causing recurrence and metastasis.
Several studies have shown that tumor resection surgery will cause a large number of tumor cells to flow into the blood and eventually cause recurrence

Method used

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  • Method and device to detect and treat diseases such as tumor or virus infection
  • Method and device to detect and treat diseases such as tumor or virus infection
  • Method and device to detect and treat diseases such as tumor or virus infection

Examples

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example 1

[0094] example 1: A device for removing pathogens from the blood, such as figure 1Shown: It includes an extracorporeal circulation circuit composed of blood outflow tube 1, plasma separator 3 and blood return tube 7 connected in sequence, and a pathogen inactivation device is connected to plasma outflow tube 4 and plasma return tube 6 of plasma separator 3 5.

[0095] The plasma flowing through the pathogen inactivation device 5 can also directly flow back into the patient's body or flow into the pipeline connecting the patient's blood vessel and the blood outflow end of the plasma separator. At this time, the plasma separator may not have a plasma return pipe.

[0096] The pathogen inactivation device 5 can be a transparent container with an ultraviolet radiation device on the outside or inside or a container with a microwave radiation device on the outside or inside. The blood outflow tube 1 is provided with a blood pump 2 . The device can also be attached with HIV adso...

example 2

[0097] Example 2: One of the plasma separators containing pathogen adsorbents for the treatment of HBV / HCV infection, such as figure 2 As shown, blood is separated into virus-containing plasma and blood cells after passing through the plasma separator. The plasma separator contains hollow fibers 8 made of multiple polysulfone membranes. The total area of ​​the hollow fibers is 1 square meter. , Membrane pore size 0.5 microns. Both ends of the container are connected by arterial and venous pipelines to allow blood to flow through the hollow fiber 8, and the hollow fiber 8 is filled with a solid-phase carrier pathogen adsorbent 9. On the solid phase carrier pathogen adsorbent 9 there are pathogen affinity substances, such as cross-linked dextran Sepharose 4B particles with a particle size of 90 um, covalently linked to anti-hepatitis B surface antigen antibody or PSMA. Plasma from the plasma outflow tube can be further passed through a virus inactivation device (such as ultr...

example 3

[0098] Example 3: The blood of patients with hepatitis C first undergoes extracorporeal circulation through the arteriovenous channel. The blood passes through a hollow fiber membrane plasma separator with a blood flow rate of 200ml / min. The separated plasma flows through a flat container that is transparent to ultraviolet rays (such as A quartz glass container with an internal volume of 10x10x1cm), the container is irradiated by an ultraviolet lamp with a wavelength of 253nm, and the radiation intensity on the container is 60μW / cm 2 , the plasma flows through the container for 30 seconds, then merges with the blood cells and flows back into the patient. The whole operation lasts 2 hours. After the above intensity of ultraviolet irradiation, more than 95% of the hepatitis C virus in the plasma sample can be inactivated by virus culture test. Heating (for example, 50-70 degrees) can also be used to kill the virus. For example, the container is placed in a microwave generato...

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Abstract

The invention provides a method to reduce the rate of tumor metastasis and tumor recurrence after surgery and chemotherapy and radiotherapy by removing circulating tumor cells (CTC) in the blood after surgery and chemotherapy and radiotherapy by means of specificity, thereby improving the survival rate of cancer patients. The invention provides a method and a system for removing tumor cells. Patients ' blood is guided out to pass through a container, an antibody or a ligand capable of combining with the specificity of the tumor cells is fixed on a solid-phase carrier in the container, whne the patients ' blood passes through the container, the tumor cells can be absorbed by the specificity to be unable to flow back to patients ' blood, and then the tumor cells are removed from the blood to reduce the recidivation of tumor patients and to prolong their survival rate. The removed tumor cells can be washed out from the solid-phase carrier for counting. The invention further provides a method to remove pathogen from blood. Blood is withdrawn from a patient and its plasma and cellular components are separated by means of a plasma separator under the effect of a blood pump, the plasma portion inactivates the pathogen in the blood via a pathogen inactivating device, flows back to extracorporeal circulation passage to merge with the cellular components and then is returned to the patient. The method adopts a physical means, so that side effects can be reduced. The device is simple in structure and can be connected with other blood purification devices.

Description

technical field [0001] The present invention relates to methods and devices for detecting and treating tumors, viral infections, autoimmune diseases and other diseases, in particular to detecting and treating diseases by removing pathogenic substances in peripheral circulating blood. The present invention relates to a device and method for treating and monitoring tumors. In particular, it relates to a device and method for preventing tumor recurrence and metastasis by eliminating free tumor cells in blood, and the invention also relates to a device and method for treating pathogenic infection. In particular, it relates to a device and method for treating infections by inactivating pathogens in the blood. Background technique [0002] The specific operation of blood purification can be found in many textbooks, literature and research reports. Blood purification includes hemodialysis, hemofiltration, hemoperfusion, plasma exchange, etc. Hemodialysis, referred to as hemodial...

Claims

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Application Information

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IPC IPC(8): A61M1/34A61M1/36A61M1/38
CPCA61M1/3679A61M1/3486A61M1/3681A61M1/3472A61M1/3623A61M2202/0415A61M2205/053A61M2205/75A61M1/3683A61M1/3616A61B18/02A61B18/04A61B18/1815A61B18/20A61B2018/00577A61M1/3621A61M1/3687A61N5/10G01N33/48
Inventor 王天欣马文斌陈以旺刘镭
Owner 王天欣
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