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Silicon-nanowire-based fluorescence chemical sensor with selective fluorescence response to free copper ions and complexing copper ions

A technology of chemical sensors and silicon nanowires, which is applied in the field of fluorescent chemical sensors, can solve the problems of lack of detection methods for complexed copper ions

Active Publication Date: 2014-04-09
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, many fluorescent sensors for detecting copper ions have been developed, but most of these sensors are aimed at the detection of free copper ions, and the detection methods for complexed copper ions are still relatively scarce.

Method used

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  • Silicon-nanowire-based fluorescence chemical sensor with selective fluorescence response to free copper ions and complexing copper ions
  • Silicon-nanowire-based fluorescence chemical sensor with selective fluorescence response to free copper ions and complexing copper ions
  • Silicon-nanowire-based fluorescence chemical sensor with selective fluorescence response to free copper ions and complexing copper ions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1) Preparation of silicon nanowires:

[0047] At room temperature, silicon monoxide is put into a porcelain boat after being ground with a mortar, and the porcelain boat is placed in the middle of the quartz tube and pushed into a vacuum tube furnace; the system is first pumped to 10 with a mechanical pump and a molecular pump -3 Pa, followed by argon (accounting for 95% of the volume of the mixed gas) and hydrogen (accounting for 5% of the volume of the mixed gas) gas mixture at a flow rate of 10 sccm (mL / min), when the pressure is stable at 10000Pa, the system starts to heat up ;The system rises to 300°C at 25°C / min, and then to 800°C at 25°C / min. At this time, close the air valve and pump gate, keep warm for 10 minutes, continue to heat up to 1350°C, and react at 1350°C for 10 hours , naturally cooled to room temperature, and the product silicon nanowires were collected on both sides of the porcelain boat. The diameter of the silicon nanowires was 5-15nm. The HRTEM p...

Embodiment 2

[0057] 1) Preparation of ordered array of silicon nanowires:

[0058] Take (100) silicon wafers of 0.5cm×3cm, and perform ultrasonic cleaning with ethanol, acetone, and distilled water for 5 to 35 minutes; then place the silicon wafers in 1% HF aqueous solution for 20 minutes; take out the silicon wafers placed in AgNO with a concentration of 3mmol / L 3 and 2mol / L HF mixed aqueous solution for 10 minutes; take out the silicon chip and immerse it in 1mol / L HF and 0.05mol / L H 2 o 2 in a water bath at 65°C for 55 minutes; put the silicon chip taken out into a mixture of concentrated hydrochloric acid (mass concentration: 36%):concentrated nitric acid (mass concentration: 36%) with a volume ratio of 3:1 , soaked for 3 hours, took out the silicon wafer and rinsed it with distilled water and dried it naturally to obtain an ordered array of silicon nanowires composed of silicon nanowires. The SEM photo of the ordered array of silicon nanowires is as follows: figure 2 As shown, whe...

Embodiment 3

[0067] 1) Preparation of silicon nanowires:

[0068] At room temperature, silicon monoxide is put into a porcelain boat after being ground with a mortar, and the porcelain boat is placed in the middle of the quartz tube and pushed into a vacuum tube furnace; the system is first pumped to 10 with a mechanical pump and a molecular pump -3 Pa, followed by argon (accounting for 95% of the volume of the mixed gas) and hydrogen (accounting for 5% of the volume of the mixed gas) gas mixture at a flow rate of 40sccm (mL / min), when the pressure is stable at 750Pa, the system starts to heat up ;The system rises to 300°C at 10°C / min, and then to 800°C at 10°C / min. At this time, close the air valve and pump gate, keep warm for 40 minutes, continue to heat up to 1350°C, and react at 1350°C for 3 hours , naturally cool to room temperature, collect the product silicon nanowires on both sides of the porcelain boat, the diameter of the silicon nanowires is 5-15nm;

[0069] 2) Surface activati...

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Abstract

The invention relates to a silicon-nanowire-based fluorescence chemical sensor with selective fluorescence response to free copper ions and complexing copper ions as well as a preparation method and application of the silicon-nanowire-based fluorescence chemical sensor. A silicon nanowire or a silicon nanowire ordered array is reacted with 3-2-(2-amino ethyl amino) ethyl amino propyl trimethoxy silane and dansyl chloride after being subjected to surface activation, so that surface functionalized modification of the silicon nanowire or the silicon nanowire ordered array is realized, and the fluorescence chemical sensor is obtained. The fluorescence chemical sensor disclosed by the invention can be used for detecting the free copper ions and the complexing copper ions in a common solution system and a biological system which contain the free copper ions and the complexing copper ions and can be used as a substrate for cell growth to construct an active detection chip with cells; furthermore, the silicon-nanowire-based fluorescence chemical sensor can be used for observing the release of the free and complexing copper ions in a cell withering process in real and time and in situ.

Description

technical field [0001] The invention belongs to the field of fluorescent chemical sensors with nanostructures, in particular to a silicon nanowire-based fluorescent chemical sensor with selective fluorescent response to free copper ions and complexed copper ions, a preparation method thereof, and an application of the fluorescent chemical sensor. Background technique [0002] As one of the most abundant metal ions in the human body, copper ions play a very important role in regulating the physiological processes of the human body. In organisms, most copper ions exist in a complex state: a part of copper ions binds to some specific proteins, and a part binds to numerous small molecule nutrients. These copper ion complexes play a crucial role in the biocatalytic process. Although the total concentration of copper ions in organisms is generally as high as 100 micromolar, the free copper ions are very small, even less than one in each cell. In recent years, many fluorescent se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
Inventor 师文生苗荣穆丽璇
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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