Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy

A technology of carboxymethyl chitosan and bioactive molecules, which is applied in the field of surface modification of magnesium alloys, can solve problems such as easy corrosion, achieve simple operation, improve corrosion resistance and biocompatibility, and overcome the effects of easy falling off

Inactive Publication Date: 2014-03-26
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the active nature of magnesium alloys, it is easy to corrode in aqueous solution, so the modification of magnesium alloys by dopamine has not been reported yet.

Method used

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  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy
  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy
  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Cathodic liquid phase plasma treatment

[0030] Use 2500-mesh and 5000-mesh sandpaper to polish the surface of the magnesium alloy until it is bright, remove the oxide layer on the surface, then use acetone to ultrasonically clean it for 3 times, each time for 5 minutes, then use 5000-mesh sandpaper to smooth the surface of the graphite rod, and then use ethanol to ultrasonically clean it. Wash 3 times, 5 minutes each time. Using 0.08mol / L NaCl water-ethanol solution as the electrolyte, the volume ratio of deionized water to absolute ethanol is 1:4, with the cleaned magnesium alloy as the cathode and the cleaned graphite rod as the anode, immersed in the electrolytic In the liquid, using a DC pulse power supply, adjusting the discharge voltage to 400V, the frequency to 100Hz, the duty cycle to 30%, and the distance between the cathode and the anode to 4cm, the cathode liquid phase plasma deposition is carried out on the magnesium alloy, and the discharge treatment ti...

Embodiment 2

[0038] In step 1 of the cathodic liquid-phase plasma treatment of the present embodiment, the water-ethanol solution of 0.05mol / L NaCl is used as the electrolyte, wherein the volume ratio of deionized water to absolute ethanol is 1:2, and a DC pulse power supply is used. The discharge voltage is 350V, the frequency is 150Hz, the duty ratio is 25%, and the distance between cathode and anode is 5cm. The magnesium alloy is subjected to cathodic liquid phase plasma deposition. The discharge treatment time is 20 minutes, and the MgO corrosion-resistant coating is formed on the surface of the magnesium alloy. . The other steps were the same as in Example 1 to obtain a magnesium alloy with surface-bonded carboxymethyl chitosan bioactive molecules.

Embodiment 3

[0040] In the cathodic liquid phase plasma treatment step 1 of the present embodiment, the water-ethanol solution of 0.12mol / L NaCl is used as the electrolyte, wherein the volume ratio of deionized water to absolute ethanol is 1:5, and a DC pulse power supply is used. The discharge voltage is 500V, the frequency is 130Hz, the duty ratio is 35%, and the distance between cathode and anode is 3cm. The magnesium alloy is subjected to cathodic liquid phase plasma deposition. The discharge treatment time is 10 minutes, and the MgO corrosion-resistant coating is formed on the surface of the magnesium alloy. . The other steps were the same as in Example 1 to obtain a magnesium alloy with surface-bonded carboxymethyl chitosan bioactive molecules.

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Abstract

The invention discloses a method for bonding carboxymethyl chitosan bioactive molecules on the surface of magnesium alloy. According to the method, a dopamine polymer film is formed on the surface of the magnesium alloy subjected to cathode liquid phase plasma processing by means of spontaneous deposition and polymerization of dopamine hydrochloride in alkaline ethanol solutions, and the carboxymethyl chitosan can be bonded on the surface of the magnesium alloy through the amidation between amidogen and carboxyl in a dopamine polymer medium layer. According to the method, the operation is easy, a carboxymethyl chitosan film layer formed on the surface of the magnesium alloy is flat and smooth and not prone to falling off, corrosion resistance and biocompatibility of the magnesium alloy can be effectively improved, the defects that the surface of a coating obtained through the cathode liquid phase plasma processing is rough, multiporous and crackled are overcome, the defect that a polymer coating formed through a physical modification method is prone to falling off is also overcome, and therefore the method lays the foundation for magnesium alloy to be used as biomedical materials.

Description

technical field [0001] The invention belongs to the technical field of magnesium alloy surface modification, and specifically relates to a method of bonding carboxymethyl chitosan on the surface of a magnesium alloy by using a polydopamine film as a medium layer and combining cathodic liquid phase plasma technology and chemical modification technology Methods for Bioactive Molecules. Background technique [0002] As a new type of biomedical material, magnesium alloy has attracted extensive attention due to its excellent mechanical properties, good biocompatibility and unique biodegradability. Magnesium alloy has low density, high specific strength and specific stiffness, elastic modulus and compressive strength close to natural bone, and magnesium is an essential element for human metabolism, which can promote the growth of bone tissue. Therefore, magnesium alloys have great application potential in orthopedics and cardiovascular system repair. However, the corrosion resis...

Claims

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Application Information

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IPC IPC(8): B05D7/14B05D7/24C25D9/12
Inventor 陈亚芍易金红黄林林
Owner SHAANXI NORMAL UNIV
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