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Preparation method of triptolide nano coating agent

A technology of triptolide alcohol and film coating agent, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve problems such as application limitations, toxic side effects, etc. Dosage, reduce toxic side effects, and avoid the effect of liver first-pass effect

Inactive Publication Date: 2014-03-12
FUJIAN ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application is greatly limited due to its relatively toxic and side effects on the digestive system, urinary system and blood system.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A triptolide nano-coating agent, characterized in that: its preparation method comprises the following steps:

[0030] Step 1) Preparation of nanoparticles: Dissolve 0.1g triptolide, 0.6g lecithin and 0.1g stearic acid in 150mL acetone, in 1.5×10 6 Emulsion 5 times under Pa, add 100mL containing mass fraction to the aqueous solution of 0.1% surfactant, evaporate the solvent under reduced pressure, make the nanoparticles precipitate from the suspoemulsion;

[0031] Step 2) Freeze-drying: use vacuum freeze-drying, pre-freeze the nanoparticles at -20°C for 3h, then adjust the pressure to 8Pa, and dry at 20°C for 15h. The diameter of the dried triptolide nanoparticles is 100nm, and they are distributed for use ;

[0032] Step 3) Preparation of sol: mix polyvinyl acetal and PEG400 as a matrix and add to water, swell in a water bath at 90°C to form a gel, dissolve borneol, glycerin, and azone in absolute ethanol, add to the gel, and stir well To completely dissolve; step 3)...

Embodiment 2

[0042] A triptolide nano-coating agent, characterized in that: its preparation method comprises the following steps:

[0043] Step 1) Preparation of nanoparticles: Dissolve 80g of triptolide, 550g of lecithin and 370g of stearic acid in 160mL of dichloromethane in 1.5×10 6 Emulsion 5 times under Pa, add 50mL containing the aqueous solution that the mass fraction is 0.2% surfactant, evaporate the solvent under reduced pressure, make the nanoparticle separate out from the suspoemulsion;

[0044] Step 2) Freeze-drying: use vacuum freeze-drying, pre-freeze the nanoparticles at -30°C for 2h, then adjust the pressure to 10Pa, and dry at 23°C for 16h. The diameter of the dried triptolide nanoparticles is 150nm, and they are distributed for use ;

[0045] Step 3) Preparation of sol: mix polyvinyl acetal and PEG400 as a matrix and add to water, swell in a water bath at 90°C to form a gel, dissolve borneol, glycerin, and azone in absolute ethanol, add to the gel, and stir well To comp...

Embodiment 3

[0055] A triptolide nano-coating agent, characterized in that: its preparation method comprises the following steps:

[0056] Step 1) Preparation of nanoparticles: Dissolve 10og triptolide, 56g lecithin and 340g stearic acid in 175mL chloroform in 1.5×10 6 Emulsion 5 times under Pa, add 60mL containing the aqueous solution that mass fraction is 0.3% surfactant, evaporate the solvent under reduced pressure, make the nanoparticle separate out from the suspoemulsion;

[0057] Step 2) Freeze-drying: use vacuum freeze-drying, pre-freeze the nanoparticles at -40°C for 1 hour, then adjust the pressure to 5Pa and dry at 25°C for 20 hours. ;

[0058] Step 3) Preparation of sol: mix polyvinyl acetal and PEG400 as a matrix and add to water, swell in a water bath at 90°C to form a gel, dissolve borneol, glycerin, and azone in absolute ethanol, add to the gel, and stir well To completely dissolve; step 3) the mass percent of each component is:

[0059] Polyvinyl acetal 40%;

[0060] PEG4...

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Abstract

The invention discloses a preparation method of a triptolide nano coating agent. The triptolide nano coating agent is prepared by the following steps: preparation of nanoparticles, freeze drying, preparation of a sol, and preparation of the nano coating agent. The coating agent prepared by the preparation method disclosed by the invention is convenient to use, so that the long-acting control-released medicine effect can be realized, the bioavailability of the medicine is improved, the use level of the medicine is reduced, the toxic and side effects of triptolide are effectively reduced, and the officinal dosage forms of triptolide are enriched.

Description

technical field [0001] The invention belongs to the research field of traditional Chinese medicine preparation technology, and in particular relates to a preparation method of triptolide nano-coating agent. Background technique [0002] Film coating agent (film coating agent) is a semi-solid coating agent for external use made by dissolving polymer film-forming materials and drugs in organic solvents. Apply the coating agent to the affected area, and after the organic solvent evaporates quickly, a thin film can be formed on the surface of the affected area to protect the affected area. At the same time, the drug contained in it is released slowly and plays a therapeutic role, so it is especially suitable for the treatment of skin diseases . [0003] Triptolide, also known as triptolide and triptolide, is a triptolide from the genus Triptolide of the family Euonymus. Tripterygium wilfordii Hook. F., Kunming Begonia T. hypoglaucum Lévl Hutch., Cangshan Tripterygium T. ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/585A61K47/34A61K47/32A61P29/00A61P19/02A61P37/02A61P35/00
Inventor 阙慧卿林绥钱丽萍
Owner FUJIAN ACAD OF MEDICAL SCI
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