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Preparation method of novel adsorbent for selectively separating ciprofloxacin in water environment

A technology for ciprofloxacin and water separation, applied in chemical instruments and methods, and other chemical processes, can solve the problems of poor adsorption-desorption kinetics, slow mass transfer and charge transfer kinetics, and active site Embedding too deep and other problems, to achieve rapid adsorption kinetics, polymer recognition performance, and reduce non-specific adsorption effects

Inactive Publication Date: 2014-02-26
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the traditional molecular imprinting technology as a whole, such as too deep embedding of active sites, slow kinetic rate of mass transfer and charge transfer, poor kinetic performance of adsorption-desorption, etc.

Method used

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  • Preparation method of novel adsorbent for selectively separating ciprofloxacin in water environment
  • Preparation method of novel adsorbent for selectively separating ciprofloxacin in water environment
  • Preparation method of novel adsorbent for selectively separating ciprofloxacin in water environment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Preparation of yeast-brominated composite material

[0044] Disperse 2 g of activated yeast in 20 mL of dichloromethane, then add 2 mL of triethylamine, ice-bath for 10 min, and pass through N 2 After deoxygenation, 1 mL of 2-bromoisobutyryl bromide was added dropwise, and reacted at room temperature for 8 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0045] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0046] Add 0.5 g of Tween-20 and 25 mL of distilled water into a 100 mL three-neck flask, sonicate for 2 min, and then stir until no bubbles are generated. Then add 0.125 mol of ciprofloxacin, 0.5 mol of methacrylic acid, 0.5 mol of hydroxyethyl methacrylate, 3 mol of ethylene glycol di(methacrylate) ester and 0.25 g of yeast-brominated composite material into the above emulsion system . The mixture was soni...

Embodiment 2

[0054] (1) Preparation of yeast-brominated composite material

[0055] Disperse 2.5 g of activated yeast in 50 mL of dichloromethane, then add 3 mL of triethylamine, ice-bath for 20 min, and pass N 2 After deoxygenation, 3 mL of 2-bromoisobutyryl bromide was added dropwise and reacted at room temperature for 10 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0056] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0057] Add 0.6 g of Tween-20 and 36 mL of distilled water into a 100 mL three-neck flask, sonicate for 5 min, and then stir until no bubbles are generated. Then add 0.2 mol of ciprofloxacin, 0.6 mol of methacrylic acid, 0.6 mol of hydroxyethyl methacrylate, 4.8 mol of ethylene glycol di(methacrylate) ester and 0.25 g of yeast-brominated composite material into the above emulsion system . The mixture was sonicated ...

Embodiment 3

[0065] (1) Preparation of yeast-brominated composite material

[0066] Disperse 3 g of activated yeast in 75 mL of dichloromethane, then add 4 mL of triethylamine, ice-bath for 40 min, and pass through N 2 After oxygen removal, 8 mL of 2-bromoisobutyryl bromide was added dropwise and reacted at room temperature for 15 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0067] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0068] Add 0.8 g Tween-20 and 52 mL distilled water into a 100 mL three-neck flask, sonicate for 10 min, and then stir until no bubbles are generated. Then add 0.25 mol of ciprofloxacin, 1 mol of methacrylic acid, 1 mol of hydroxyethyl methacrylate, 10 mol of ethylene glycol di(methacrylate) ester and 0.25 g of yeast-brominated composite material into the above emulsion system . The mixture was sonicated fo...

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Abstract

The invention relates to a preparation method of a novel adsorbent for selectively separating ciprofloxacin in water environment, and belongs to the technical field of environmental material preparation. The preparation method comprises the following steps: modifying a commercialized dry yeast as a matrix material to form an initiator grafted composite material, and synthesizing a yeast surface molecule imprinting adsorbent in an environmentally-friendly emulsion system by utilizing a surface-initiated atom transfer radical polymerization method with ciprofloxacin as a template, methacrylic acid and hydroxyethyl methacrylate as functional monomers, ethylene glycol dimethacrylate as a cross-linking agent and cuprous bromide as a catalyst. A static state adsorption experiment is used for researching the adsorption balance, the dynamics and the selective identification performance of the prepared blotting adsorbent. A result shows that the yeast surface molecule imprinting adsorbent obtained in the invention has a rapid adsorption kinetics property and a superior identification performance on ciprofloxacin in the water environment.

Description

technical field [0001] The invention relates to a preparation method of a novel adsorbent for selectively separating ciprofloxacin in water environment, in particular, yeast is used as a matrix material, ciprofloxacin is used as a template, methacrylic acid (MAA) and hydroxyethyl methacrylate (HEMA) is a functional monomer, ethylene glycol di(methacrylate) (EGDMA) is a crosslinking agent, cuprous bromide (CuBr) is a catalyst, and atom transfer radical polymerization is used in a green and friendly emulsion system A method for synthesizing molecularly imprinted polymers on the surface of ciprofloxacin belongs to the technical field of environmental material preparation. Background technique [0002] Ciprofloxacin belongs to the third-generation fluoroquinolone antibiotics. Due to its broad antibacterial spectrum, good absorption, high blood concentration, rapid decomposition to various tissues, and long half-life, it is widely used in human medicine and animal husbandry. How...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30
Inventor 王娟孟敏佳戴江栋宋志龙李春香闫永胜
Owner JIANGSU UNIV
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