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Double-stimulus response hydrogel with cyclodextrin and preparation method thereof

A dual-stimuli-response, cyclodextrin technology, applied in the direction of non-active components of polymer compounds, can solve the problems of hydrophobic drug molecule loading and effective release, and achieve the effect of easy realization and simple preparation process

Active Publication Date: 2014-02-05
JIANGSU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, although the research and application of smart hydrogels have been greatly developed in recent years, the high hydrophilicity of the hydrogel macromolecular chains and the high water content inside the hydrogel make it difficult to load hydrophobic drug molecules. and effective release, especially with the current in-depth research on many diseases from the perspective of molecular biology, more and more molecular design methods are used to design and synthesize drug active molecules. Drug active molecules with specific effects now exhibit more hydrophobic properties

Method used

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  • Double-stimulus response hydrogel with cyclodextrin and preparation method thereof
  • Double-stimulus response hydrogel with cyclodextrin and preparation method thereof
  • Double-stimulus response hydrogel with cyclodextrin and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] 1) Preparation of cyclodextrin modified crosslinking agent:

[0024] Weigh 1.14g of cyclodextrin and 0.1g of dimethylaminopyridine and dissolve in 10mL of dimethylformamide, then drop in 0.72g of acrylic acid, and place it in a constant temperature water bath at 60°C for stirring after it is completely dissolved. Then 2.26 g of dicyclohexylcarbodiimide was weighed and dissolved in 10 mL of dimethylformamide, and dropped into the above solution drop by drop to react for 10 h. After the reaction, it was cooled to room temperature, and the precipitated solid was removed by vacuum filtration, and the filtrate was precipitated with acetone, and the obtained white solid product was placed in a vacuum oven, and dried at 70°C until constant weight.

[0025] 2) Preparation of dual stimuli-responsive hydrogels with cyclodextrin:

[0026] Dissolve 0.24g of cyclodextrin-modified crosslinking agent, 0.24g of isopropylacrylamide and 0.12g of acrylic acid in 2mL of deionized water, a...

Embodiment 2

[0028] 1) Preparation of cyclodextrin modified crosslinking agent:

[0029] Weigh 1.14g of cyclodextrin and 0.1g of dimethylaminopyridine and dissolve in 7mL of dimethylformamide, then drop in 0.34g of acrylic acid, and place it in a constant temperature water bath at 50°C for stirring after it is completely dissolved. Then 1.07 g of dicyclohexylcarbodiimide was weighed and dissolved in 6 mL of dimethylformamide, and dropped into the above solution drop by drop to react for 8 h. After the reaction, it was cooled to room temperature, and the precipitated solid was removed by vacuum filtration. The filtrate was precipitated with acetone, and the obtained white solid product was placed in a vacuum oven and dried at 60° C. to constant weight.

[0030] 2) Preparation of dual stimuli-responsive hydrogels with cyclodextrin:

[0031] Dissolve 0.24g of cyclodextrin-modified crosslinking agent, 0.18g of isopropylacrylamide and 0.18g of acrylic acid in 2.5mL of deionized water, add 0.05g ...

Embodiment 3

[0033] 1) Preparation of cyclodextrin modified crosslinking agent:

[0034] Weigh 1.14g of cyclodextrin and 0.1g of dimethylaminopyridine and dissolve it in 18mL of dimethylformamide, then drop in 0.84g of acrylic acid, and place it in a constant temperature water bath at 50°C for stirring after it is completely dissolved. Then 2.64 g of dicyclohexylcarbodiimide was weighed and dissolved in 15 mL of dimethylformamide, and dropped into the above solution drop by drop to react for 12 h. After the reaction, cool to room temperature, remove the precipitated solid by vacuum filtration, and precipitate the filtrate with acetone. The obtained white solid product is placed in a vacuum oven and dried at 80° C. to constant weight.

[0035] 2) Preparation of dual stimuli-responsive hydrogels with cyclodextrin:

[0036] Dissolve 0.24g of cyclodextrin crosslinking agent, 0.12g of isopropylacrylamide and 0.24g of acrylic acid in 3mL of deionized water, add 0.06g of sodium bisulfite, pass n...

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Abstract

The invention discloses a double-stimulus response hydrogel with cyclodextrin and a preparation method thereof. A gel macromolecular chain is provided with a cyclodextrin group, a temperature sensitive unit and a pH value sensitive unit, wherein the weight percentage of the cyclodextrin group contained in a gel macromolecule is 14%-57%; the temperature sensitive unit is isopropyl acrylamide, and the weight percentage of the temperature sensitive unit in the gel macromolecule is 20%-50%; the pH value sensitive unit is acrylic acid, and the weight percentage of the pH value sensitive unit in the gel macromolecule is 14%-57%. According to the invention, the prepared carrier hydrogel can be used for loading of a large quantity of drug molecules by introducing cyclodextrin and the temperature and pH value response structure units; when outside temperature and a pH value are changed, the responsive change of regulating the release speed of drugs can be generated. The preparation process of the provided double-stimulus response carrier hydrogel with the cyclodextrin group is simple and convenient and easy to realize.

Description

[0001] technical field [0002] The invention relates to the field of dual-stimuli-responsive intelligent polymer materials, in particular to a dual-stimuli-responsive hydrogel with cyclodextrin and a preparation method thereof. Background technique [0003] The development of modern medicine and the improvement of people's living standards require drug delivery carriers to deliver drugs to designated sites at a predetermined release rate within a predetermined time, so as to maximize the bioavailability of drug molecules and reduce drug toxicity. purpose of side effects. Hydrogel is one of ideal materials used as this controlled release drug carrier (Pepas N.A., Bures P., Leobandung W., Ichikawa H., Hydrogels in pharmaceutical formulations, European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50: 27 -46). Generally speaking, hydrogel is a three-dimensional network constructed by hydrophilic macromolecular chains, which can be highly swollen in water and retain a ...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/54C08F220/06C08B37/16A61K47/40
Inventor 胡杰吴新振吉海燕巢艳红陈晓军
Owner JIANGSU UNIV
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