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Azlocillin sodium composition powder for injection

A technology of azlocillin sodium and its composition, which is applied in the field of pharmaceuticals and pharmaceutical manufacturing, can solve the problems of not containing chitosan nanoparticles, etc., and achieve the effects of good stability, plump appearance, and good resolubility

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Chitosan nanoparticles are microparticles with a particle size of less than 100nm. As a drug carrier, they have slow-release and targeting effects and broad-spectrum antibacterial properties. They have certain inhibitory effects on the growth of various bacteria. There are no pharmaceutical dosage forms containing chitosan nanoparticles on

Method used

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  • Azlocillin sodium composition powder for injection
  • Azlocillin sodium composition powder for injection
  • Azlocillin sodium composition powder for injection

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Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1, preparation of azlocillin sodium composition freeze-dried powder for injection, in 1000 pieces.

[0038] Prescription:

[0039] Azlocillin Sodium 200g

[0040] Chitosan Nanoparticles 40g

[0041] Water for injection 2000ml

[0042] 2. Preparation process:

[0043] The chitosan nanoparticle that takes by weighing 40g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0044] Add 200 g of azlocillin sodium and stir to dissolve until clear.

[0045] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of azlocillin sodium 0.2g per bottle.

[0046] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool down ...

Embodiment 2

[0047] Embodiment 2, preparation of azlocillin sodium composition freeze-dried powder for injection, in 1000 pieces.

[0048] 1. Prescription:

[0049] Azlocillin Sodium 200g

[0050] Chitosan Nanoparticles 28g

[0051] Water for injection 2000ml

[0052] 2. Preparation process:

[0053] The chitosan nanoparticle that takes by weighing 28g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0054] Add 200 g of azlocillin sodium and stir to dissolve until clear.

[0055] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of azlocillin sodium 0.2g per bottle.

[0056] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool do...

Embodiment 3

[0057] Embodiment 3, preparation of azlocillin sodium composition freeze-dried powder for injection, in 1000 pieces.

[0058] Prescription:

[0059] Azlocillin Sodium 200g

[0060] Chitosan Nanoparticles 52g

[0061] Water for injection 2000ml

[0062] 2. Preparation process:

[0063] The chitosan nanoparticle that takes by weighing 52g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0064] Add 200 g of azlocillin sodium and stir to dissolve until clear.

[0065] Adjust the pH to 5.1 with the buffer salt of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of azlocillin sodium 0.2g per bottle.

[0066] Fill according to the test requirements, put it into a freeze dryer after half-tamping, cool down to...

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Abstract

The invention provides an azlocillin sodium composition powder for injection, and belongs to the field of medicine and medicine preparation technology. The azlocillin sodium composition powder comprises following raw material ingredients, by weight, 7.26 to 9.17 parts of azlocillin sodium, 1.45 to 1.84 parts of chitosan nanoparticle, and 88.99 to 91.29 parts of injection water. Advantages of the azlocillin sodium composition powder are that: the size of the chitosan nanoparticle is ultra small, so that the chitosan nanoparticle is capable of passing through capillary vessels with a smallest diameter, rapid removing of the chitosan nanoparticle by macrophage is avoided, so that lasting time of the azlocillin sodium composition in blood is prolonged greatly; the azlocillin sodium composition is capable of improving antimicrobial activity of azlocillin sodium significantly, reducing dosage of azlocillin sodium in clinic, and reducing adverse reaction of azlocillin sodium; and the chitosan nanoparticle can be used as a freeze-dried skeleton agent of the freeze-dried powder injection instead of mannitol so as to avoid active effects of mannitol on human bodies.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a freeze-dried powder injection of an azlocillin sodium composition for injection. Background technique: [0002] The chemical name of azlocillin sodium is [1](2S,5R,6R)-3,3-dimethyl-6-[[[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenyl Acetyl]amino]-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid sodium salt. [0003] Azlocillin sodium is white or off-white powder or loose lump, odorless, slightly bitter taste, hygroscopic, easily soluble in water, slightly soluble in ethanol, insoluble in ethyl acetate or acetone. [0004] Azlocillin sodium structural formula: [0005] [0006] Azlocillin sodium is a broad-spectrum semi-synthetic urea-based penicillin. As the third-generation broad-spectrum semi-synthetic penicillin, it is effective against G+ bacteria, G- bacteria and anaerobic bacteria, and can strongly resist Pseudomonas aeruginosa. It...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K47/36A61K9/19A61P31/04A61K31/431
Inventor 汪六一汪金灿李珠珠
Owner HAINAN WEI KANG PHARMA QIANSHAN
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