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A kind of dexamethasone implant

A technology of dexamethasone and implants, which is applied in the direction of anti-inflammatory agents, non-central analgesics, and medical preparations of non-active ingredients, and can solve the difficulties of production, storage, and transportation, and the implantation of implants into the eye , Implant instability and other issues, to avoid toxic and side effects, stable drug release characteristics, and small systemic adverse reactions

Active Publication Date: 2015-12-02
合肥中人科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The disadvantages of this technical solution are three: one is that the auxiliary material PLGA is easily degraded under wet and hot conditions, and the implants made are unstable and difficult to produce, store and transport; the other is that the process is only suitable for heat-stable drugs. For thermally unstable drugs, the thermal decomposition of the drug will be caused by melt extrusion; the third is that the implant is implanted in the eye during surgery, and it is not suitable for percutaneous implantation into the renal capsule

Method used

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  • A kind of dexamethasone implant
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 prepares dexamethasone implant (A)

[0064]

[0065] Grind the above materials separately, pass through 120 sieves for dexamethasone and polylactic acid, and pass through 150 sieves for polyethylene glycol, weigh and mix according to the prescription amount, a total of 5g, mix evenly in a mixer, oscillate and put into 141 holes with an aperture of 0.9mm Put it in a stainless steel mold, put it in a ZR-II drug press machine (developed by Anhui Zhongren Technology Co., Ltd.), press it at 320Mpa, and demold it to obtain the dexamethasone implant (A).

[0066] The implant is easy to demould, has a smooth surface, and is a white cylinder with a diameter of 0.9mm, a length of 2.3mm, an intensity of 42MPa, and 90% of the drug release time is 30 days, see Example 4 and figure 1 .

Embodiment 2

[0067] Embodiment 2 prepares dexamethasone implant (B)

[0068]

[0069] Except that the pressure of the medicine press was 410Mpa, all the other preparation techniques were the same as in Example 1 to obtain the dexamethasone implant (B).

[0070] The implant is easy to demould, has a smooth surface, and is a white cylinder with a diameter of 0.9mm, a length of 2.1mm, a strength of 51MPa, and a 90% release time of 60 days, see Example 4 and figure 1 .

Embodiment 3

[0071] Embodiment 3 prepares dexamethasone implant (C)

[0072]

[0073] Except that the pressure of the medicine press is 480Mpa, all the other preparation processes are the same as in Example 1 to obtain the dexamethasone implant (C).

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Abstract

The invention relates to a dexamethasone implant, and a preparation method, purpose and an application method thereof. The implant is a circular column with diameter of 0.2-1.2 mm and length of 1-5 mm; and the implant is prepared from dexamethasone medicine, polylactic acid and polyethylene glycol through compacting. It takes the implant 7-180 days to release 90% of the medicine in human body; and the implant can be implanted into saccus renalis through medicine implant needle percutaneous puncture for treating chronic nephritis, or implanted into positions requiring long-time dexamethasone medication treatment for regional continuous long-time medicament treatment.

Description

technical field [0001] The invention relates to a dexamethasone implant and a preparation method thereof, in particular to the composition, shape, size, release characteristics and preparation method of a dexamethasone implant. [0002] The invention also relates to the application and application method of the dexamethasone implant. Background technique [0003] Dexamethasone is an adrenocortical hormone drug with anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects, and is mainly used for the treatment of severe bacterial infections and severe allergic diseases, various thrombocytopenic purpura, and neutropenia , severe skin diseases, immune rejection of organ transplantation, tumor treatment and inflammation sensitive to glucocorticoids, etc. [0004] Three chemical forms of dexamethasone are used clinically as drugs: dexamethasone, dexamethasone acetate, and dexamethasone sodium phosphate. Dexamethasone is easily absorbed from the digestive t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/573A61K47/34A61P29/00A61P37/08A61P37/06A61P7/04A61P31/04A61P7/00A61P17/00A61P35/00A61P13/12A61K47/10
Inventor 王世亮许健健吴永贵尹情胜陈殿良马建华徐德钧俞敏任翠丽周丽春邵娟
Owner 合肥中人科技有限责任公司
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