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Pharmaceutical composition, and preparation method and application thereof

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of uncontrollable normal blood glucose level, weight gain, etc., and achieve the effects of novel formula, convenient taking and low price

Active Publication Date: 2013-06-05
HILL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the disadvantages of using sulfonylurea-based drugs is the inability to control normal blood glucose levels
These drugs also adversely affect the ability of β-cells to secrete insulin and may lead to weight gain

Method used

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  • Pharmaceutical composition, and preparation method and application thereof
  • Pharmaceutical composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Preparation of raw materials:

[0041] Fenugreek extract: extract fenugreek seeds at 60°C with ethanol with a mass concentration of 50% for 2-3 times, 1-3 hours each time; filter, discard the filter residue, and combine the filtrate; concentrate the filtrate to a relative density of 1.00 After -1.15, use 90% ethanol alcohol precipitation with 3 times the mass of the filter residue, and take its supernatant; the supernatant is adsorbed with an ion exchange resin for amino acids, then rinsed with deionized water, and then analyzed with 1N ammonia water. , to obtain the analysis solution; the analysis solution is concentrated and then dried to obtain the fenugreek extract;

[0042] Extract of plantago seed: reflux extract plantago seed with 75% ethanol aqueous solution with a mass concentration 4 times the mass of plantago seed for 3-5 times, each time for 1-2h; collect extract, filter, concentrate to remove solvent , and diluted with water to obtain a suspension solu...

Embodiment 2

[0047] (1) Preparation of raw materials:

[0048] Fenugreek extract: extract fenugreek seeds at 70°C with ethanol with a mass concentration of 60% for 2-3 times, 1-3 hours each time; filter, discard the filter residue, and combine the filtrate; concentrate the filtrate to a relative density of 1.15 Finally, use 85% ethanol alcohol precipitation with respect to 4 times the quality of the filter residue, and get its supernatant; the supernatant is adsorbed amino acids with ion exchange resin, then rinsed with deionized water, and then resolves the cationic resin column with 1.5N ammonia water, Obtain the analysis solution; the analysis solution is concentrated and then dried to obtain the fenugreek extract;

[0049] Plantago seed extract: use 80% ethanol aqueous solution with a mass concentration of 6 times the mass of Plantago seed to reflux extract the plantago seed for 5 times, each time for 1-2h; collect the extract, filter, concentrate to remove the solvent, add water Dilu...

Embodiment 3

[0054] Healthy male mice (22±2) g were selected and randomly divided into normal group (6 mice) and model group. The model group was intraperitoneally injected with streptozotocin 150 mg / kg, and their tails were cut to measure their random blood glucose after 48 hours. Screen the mice whose blood sugar value exceeds 10.1mmol / L to enter the experiment, and be divided into model group, positive drug group glyburide (3mg / kg.day), pharmaceutical composition FL of the present invention 1 High-dose group (300mg / kg.day gavage), the pharmaceutical composition FL of the present invention 1 Middle dose group (200mg / kg.day gavage), the pharmaceutical composition FL of the present invention 1 The low-dose group (100mg / kg.day gavage) was administered orally orally for four consecutive weeks. After the administration, the serum insulin and fasting blood glucose values ​​of the mice were measured. The experimental data were analyzed by variance analysis, and the results were expressed as X±...

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Abstract

The invention belongs to the technical field of pharmaceutical compositions, and discloses a hypoglycemic medicine for treating diabetes, and a preparation method and application thereof. The pharmaceutical composition is composed of the following components in parts by weight: 30-60 parts of fenugreek extract, 20-30 parts of Plantain seed extract, 50-60 parts of gardenia extract and 10-20 parts of konjak crude drug. The medicine disclosed by the invention has obvious functions of lowering blood sugar and promoting insulin secretion, has the advantages of novel formula, reliable quality, low price and no obvious side effect, and is convenient to take.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating diabetes prepared from Chinese herbal medicines and its preparation method and application. Background technique [0002] Diabetes is a common multiple disease that seriously endangers human health. It is difficult to cure and has extensive and serious complications. It is estimated that by 2025, the number of people with diabetes in China will reach 36 million, ranking second in the number of people with diabetes in the world, and most of them will be between the ages of 45 and 64. Diabetes can be divided into four types: Type 1 diabetes, Type II diabetes, gestational diabetes and specific type of diabetes. Type II diabetes is the result of the joint action of genetic and environmental factors, accounting for more than 90% of the total number of diabetics, more common in overweight or obese middle-aged and elderly people, and has obvious ...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P3/10A61P5/50
Inventor 周阳峰
Owner HILL PHARMA
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