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Cefixime capsule and preparation method thereof

A technology of cefixime and capsules, which is applied in the field of cefixime capsules and its preparation, can solve the problems affecting the speed and effect of drug treatment, slow drug absorption and distribution, and low dissolution rate, so as to shorten the production cycle and reduce production costs , The effect of simple production process

Active Publication Date: 2013-05-22
贝克诺顿(浙江)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cefixime preparations reported in the above literature all have poor stability, low dissolution rate, slow absorption and distribution of the drug in the body, which affects the treatment speed and effect of the drug.

Method used

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  • Cefixime capsule and preparation method thereof
  • Cefixime capsule and preparation method thereof
  • Cefixime capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dissolve 500g of cefixime and 750g of lecithin in 10L of methanol, add 200g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 50°C, take out the evaporated compound, grind it through a 80-100 mesh sieve, and obtain The cefixime phospholipid complex of silicon dioxide; take by weighing 145g the cefixime phospholipid complex containing silicon dioxide, dry granulate after mixing with 180g lactose, 30g croscarmellose sodium, the gained dry granule and 3.5 g of talcum powder was mixed evenly and filled into capsule shells to obtain cefixime capsules.

Embodiment 2

[0023] Dissolve 500g of cefixime and 1000g of lecithin in 10L of methanol, add 250g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 45°C, take out the evaporated compound, crush it through a 80-100 mesh sieve, and obtain The cefixime phospholipid complex of silicon dioxide; take by weighing 175g the cefixime phospholipid complex containing silicon dioxide, dry granulate after mixing with 200g microcrystalline cellulose, 25g crospovidone, the gained dry granule and 4.0 g of talcum powder was mixed evenly and filled into capsule shells to obtain cefixime capsules.

Embodiment 3

[0025] Dissolve 500g of cefixime and 1250g of distearoylphosphatidylcholine in 10L of methanol, add 200g of silicon dioxide, and stir; evaporate the methanol to dryness under reduced pressure below 50°C, take out the evaporated complex, and crush it over 80- 100 mesh sieves to obtain the cefixime phospholipid complex containing silicon dioxide; weigh 195g of the cefixime phospholipid complex containing silicon dioxide, mix it with 180g microcrystalline cellulose, 45g mannitol, and 35g low-substituted hydroxypropyl fiber Dry granulation after uniform mixing, and the obtained dry granules are mixed with 4.0 g of talcum powder and packed into capsule shells to obtain cefixime capsules.

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Abstract

The invention discloses a cefixime capsule and a preparation method thereof. The preparation is prepared by uniformly mixing dry particles and talcum powders, and filling the mixture into a capsule shell, wherein the dry particles are prepared by uniformly mixing cefixime phospholipid complex containing silicon dioxide, a filler and a disintegrating agent, through dry granulating; and in the cefixime phospholipid complex containing silicon dioxide, the weight ratio of the cefixime to the phospholipid to the silicon dioxide is 1: (1-3): (0.2-0.8). The cefixime capsule prepared by the invention is strong in stability, high in dissolution degree and simple in production process.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a cefixime capsule which can dissolve rapidly in vivo and in vitro and a preparation method thereof. Background technique [0002] Cefixime (Cefixime), chemical name: 6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-8 -Oxo-3-ethylene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate, molecular formula: C 16 h 15 N 5 o 7 S 2 ·3H 2 O, the molecular weight is 507.50, the structural formula is as follows: [0003] [0004] Cefixime is a third-generation oral cephalosporin that acts as a bactericidal agent by inhibiting the synthesis of bacterial cell walls. Cefixime has good effects on Gram-positive cocci such as pneumococcus and Streptococcus pyogenes in vitro and in vivo, and Gram-negative bacilli such as influenza bacilli, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, and Neisseria gonor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/546A61K47/48A61K47/24A61K47/04A61P31/04
Inventor 吴伟薛春雅朱乐民钱晓俊许高伟
Owner 贝克诺顿(浙江)制药有限公司
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