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Loratadine film preparation

A technology for loratadine and film-like preparations, which is applied to the field of drug-film preparations containing loratadine, can solve the problems of mutual influence, difficult to disperse uniformly, influence the solubility of substance B, etc., and achieves the effects of increasing beauty and improving interest

Active Publication Date: 2013-05-08
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acidic agent and alkaline agent in the effervescent agent react during the pulping process and cannot remain in the film at the same time
2) When preparing the compound film, due to the different physical and chemical properties of the active ingredients in the compound, the suitable prescription and process are different, and sometimes they will affect each other
For example, in a compound composed of A and B, acidic auxiliary materials can enhance the stability of substance A, but affect the solubility of substance B, making it difficult for B to disperse evenly during the pulping process

Method used

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  • Loratadine film preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] 1) Take 30g of loratadine and add 700ml of distilled water, stir and disperse evenly, then add 30g of sucralose, 10g of PEG400, 0.2g of brilliant blue and 20g of maleic acid while stirring, finally add 50g of PVP and 60g of HPMC, stir evenly, pass through 80 mesh Sieve, remove insoluble matter, vacuum defoaming. Obtain slurry A.

[0094] 2) Take 30g of loratadine and add 700ml of distilled water, stir and disperse evenly, then add 30g of sucralose, 10g of PEG400, 0.2g of brilliant blue and 20g of sodium bicarbonate while stirring, and finally add 50g of PVP and 60g of HPMC, stir evenly to form a high-viscosity mixture The solution was passed through an 80-mesh sieve to remove insoluble matter and vacuum defoamed. Obtain slurry B.

[0095] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dryer, coat with a coa...

Embodiment 2

[0101] 1) Take 60g of loratadine and add 600ml of distilled water, stir and disperse evenly, then add 10g of aspartame, 20g of sucralose, 0.2g of erythrosine, 0.2g of BHT and 10g of citric acid while stirring, and finally add 100g of PEO , stir evenly, pass through an 80-mesh sieve, remove insoluble matter, and vacuum defoam. Obtain slurry A.

[0102]2) Take 10g of loratadine and add 500ml of distilled water, stir and disperse evenly, then add 18g of cyclamate, 2g of vitamin E and 20g of potassium carbonate while stirring, and finally add 130g of PEO and 20g of CMC-Na, stir evenly, pass through a 80-mesh sieve to remove insoluble material, vacuum defoaming. Obtain slurry B.

[0103] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dryer, coat with a coating blade, spread the film on a stainless steel belt, and dry a...

Embodiment 3

[0109] 1) Take 10g of loratadine, add 500ml of distilled water, stir and disperse evenly, then add 15g of cyclamate, 10g of titanium dioxide and 15g of tartaric acid while stirring, and finally add 100g of PVP and 50g of cornstarch, stir evenly, and pass through a 80-mesh sieve to remove insoluble matter , vacuum defoaming. Obtain slurry A.

[0110] 2) Take 60g of loratadine and add 600ml of distilled water, stir and disperse evenly, then add 15g of aspartame, 10g of titanium dioxide and 15g of potassium bicarbonate while stirring, and finally add 100g of PEO, stir evenly, pass through a 80-mesh sieve to remove insoluble material, vacuum defoaming. Obtain slurry B.

[0111] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dryer, coat with a coating blade, spread the film on a stainless steel belt, and dry at 50°C fo...

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Abstract

The invention discloses a loratadine film preparation. The preparation comprises a strip-shaped film tape and an effective amount of an active medicine loratadine loaded thereon; the strip-shaped film tape comprises an acidic strip-shaped film tape and an alkaline strip-shaped film tape, and the acidic strip-shaped film tape and the alkaline strip-shaped film tape are connected into one and are arranged in an interval mode; the acidic strip-shaped film tape is based on a high-water-solubility polymer film forming material, and contains 1-20wt% of an acidic agent; the alkaline strip-shaped film tape is based on the high-water-solubility polymer film forming material, and contains 1-20wt% of an alkaline agent; and loratadine is loaded on the acidic strip-shaped film tape, or on the alkaline strip-shaped film tape, or simultaneously on the acidic strip-shaped film tape and the alkaline strip-shaped film tape. The loratadine film preparation becomes an effervescent film after meeting with water, and can palsy olfaction to cover a smell, and the dissolution of the loratadine film preparation can be accelerated.

Description

technical field [0001] The invention relates to a loratadine preparation, in particular to a drug film preparation containing loratadine. Background technique [0002] Loratadine is a long-acting tricyclic antihistamine. Clinically used to relieve symptoms related to allergic rhinitis, such as sneezing, runny nose and nasal itching, eye itching and burning sensation, and also used to relieve symptoms of chronic urticaria and other allergic skin diseases. It is prepared into a drug film preparation, which does not need to be taken with water and dissolves on the tongue. It is especially suitable for children, improves patient compliance, and is welcomed by patients; and its production process is simple, consumes less energy, and has low cost. [0003] There have been many researches on drug film preparations as early as the 1970s, such as stable drug film (Chinese Journal of Pharmaceutical Industry, 1976, 12 (19)), phenethylpiperidine drug film (Chinese Journal of Pharmaceut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4545A61K47/38A61K47/36A61K47/34A61K47/32A61P37/08A61P11/02A61P17/00A61K47/10A61K47/26
Inventor 陈芳侯惠民杨柳榴
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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