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UHMWPE (Ultra High Molecular Weight Polyethylene) artificial joint with surface wear-resistant layer and preparation method of same

An ultra-high molecular weight, artificial joint technology, applied in the field of ultra-high molecular weight polyethylene artificial joints and preparation, can solve the problems of unguaranteed material mechanical properties, weakened bearing capacity of joint cups, and material mechanical properties. Replacement frequency, good toughness and mechanical properties and anti-aging properties, the effect of improving wear resistance

Inactive Publication Date: 2013-04-03
NANJING UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Irradiation crosslinking can effectively improve the wear resistance of UHMWPE, but the mechanical properties of the material decrease after irradiation [Steven M. Kurtz. The UHMWPE handbook: ultra-high molecular weight polyethylene in total joint replacement. 1st ed. London: Elsevier Academic Press, 2004.], the bearing capacity of the joint acetabular cup is weakened, and it is prone to early failure in the case of artificial joint physiological impact loading[ Lei Xiong , Dangsheng Xiong, Yuanyuan Yang, Jiabo Jin. Friction, wear and tensile properties of vacuum hot pressing crosslinked UHMWPE / nano-HAP composites. Journal of Biomedical Materials Research B: Applied Biomaterials, Volume 98B, Issue 1, 127-138, 2011] , the wear resistance of the knee joint after irradiation cross-linking is lower than that of the hip joint [Fisher J, McEwen HM, Tipper JL, et al. Wear, debris, and biological activity of cross-linked polyethylene in the knee : benefits and potential concerns. Clinical Orthopaedics & Related Research, 2004,428:114-119.], patent CN201010129279.5 mentions a preparation method of an anti-irradiation-oxidized artificial joint socket, which can inhibit the artificial joint material from However, the overall material is still the material after irradiation, and the mechanical properties of the material cannot be guaranteed. Therefore, it is necessary to propose a new type of material that has a wear-resistant surface layer and can maintain good mechanical properties of the substrate. artificial joint

Method used

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  • UHMWPE (Ultra High Molecular Weight Polyethylene) artificial joint with surface wear-resistant layer and preparation method of same

Examples

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preparation example Construction

[0022] combine figure 1 , the artificial joint of the present invention consists of a wear-resistant layer 1 and a matrix 2, and its preparation method comprises the following steps:

[0023] (1) Vacuum packaging the composite of ultra-high molecular weight polyethylene (medical grade, molecular weight greater than 2 million) and nanoparticles (composite powder or composite powder formed by vacuum hot pressing). The mass fraction of nanoparticles is 0-10%. Nanoparticles are inorganic nanoparticles whose surface is modified by a coupling agent, such as nano-hydroxyapatite, nano-alumina, zirconia or silica, etc. The composite powder is blended by ball milling Preparation, the ball milling speed is 300rpm, and the time is 2 hours;

[0024] (2) Gamma ray irradiation is performed on the vacuum-packed complex, the gamma ray is produced by a cobalt-60 ray source, and the selected irradiation dose is less than or equal to 200kGy;

[0025] (3) The vacuum-irradiated composite and pur...

Embodiment 1

[0027] Example 1: Vacuum irradiated pure ultra-high molecular weight polyethylene powder is selected, that is, the nanoparticle content is 0%.

[0028] The preparation process is as follows:

[0029] (1) Vacuum packaging of pure UHMWPE powder;

[0030] (2) Gamma ray irradiation is performed on the vacuum-packed powder, and the selected dose is 100kGy;

[0031] (3) The powder obtained by vacuum irradiation and the unirradiated pure ultra-high molecular weight polyethylene powder are layered into the mold, and the vacuum hot-pressing furnace is turned on to carry out vacuum hot-pressing on the material loaded into the mold. The specific parameters are: vacuum degree- 0.1MPa, pressure 10MPa, hot pressing temperature 150°C, holding time 1.5 hours. The prepared samples were tested on a three-station knee joint wear tester under the conditions of 25% calf serum lubrication, a load of 1062N, a CoCrMo alloy on the grinding surface, and a surface roughness of 0.1 μm. The wear rate o...

Embodiment 2

[0032] Example 2: Vacuum irradiated ultra-high molecular weight polyethylene composite powder is selected. The preparation process is as follows:

[0033] (1) Vacuum packaging ultra-high molecular weight polyethylene powder containing 1% nano-hydroxyapatite particles;

[0034] (2) Gamma ray irradiation is performed on the vacuum-packed powder, and the selected dose is 100kGy;

[0035](3) The powder obtained by vacuum irradiation and the unirradiated pure ultra-high molecular weight polyethylene powder are layered into the mold, and the vacuum hot-pressing furnace is turned on to carry out vacuum hot-pressing on the material loaded into the mold. The specific parameters are: vacuum degree- 0.1MPa, pressure 15MPa, hot pressing temperature 200°C, holding time 2 hours. The thickness of the matrix of the demoulded artificial hip joint socket sample is 8-10 mm, and the thickness of the wear-resistant layer is 2-4 mm. The prepared artificial hip joint socket samples were tested on...

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Abstract

The invention discloses a UHMWPE (Ultra High Molecular Weight Polyethylene) artificial joint with a surface wear-resistant layer and a preparation method of the UHMWPE artificial joint. Vacuum irradiated UHMWPE or a composite material thereof is used as a wear-resistant surface layer for forming a polymer composite material with a lamellar structure; and the material is applied to an artificial hip joint and an artificial knee joint tibia pad in the field of artificial joints, wherein the wear-resistant surface layer is formed by the vacuum irradiated UHMWPE or the composite material thereof and a matrix layer is prepared from unirradiated UHMWPE. Compared with the wear resistance of the unirradiated pure UHMWPE, the wear resistance of the UHMWPE artificial joint material with the surface wear-resistant layer, which is prepared by the invention, is improved for three times under the condition that a calf serum knee joint is worn; the matrix material keeps the related characteristics of original UHMWPE; physical impact resistance capacity of the material can be improved; and service life of the artificial joint is prolonged.

Description

technical field [0001] The invention belongs to implant devices, in particular to an artificial joint of ultra-high molecular weight polyethylene with a surface wear-resistant layer and a preparation method. Background technique [0002] Ultra High Molecular Weight Polyethylene (UHMWPE) is a thermoplastic engineering plastic with low friction and wear. It has been used as a bearing material for artificial joint cups for 50 years. Applied to artificial hip joints, knee joints and wrist joints, it cooperates with metal alloy or ceramic joint ball heads to form joint friction pairs. Under the conditions of human physiological impact loading and multi-directional movement, UHMWPE joint acetabular cups will produce a large number of fine wear debris after long-term use, which will induce a series of adverse physiological reactions in macrophages, release osteolytic factors, and lead to good fixation and fit. Aseptic loosening of the artificial joint occurs and eventually fails. ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/46A61L27/34A61L27/30A61L27/32A61L27/16A61L27/50A61F2/30C08J3/28
CPCA61F2/30767A61F2002/30001
Inventor 熊党生熊磊邓亚玲石雁
Owner NANJING UNIV OF SCI & TECH
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