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Drug-loading nano-fiber membrane and preparation method thereof

A nanofiber membrane and drug-loaded nanotechnology, which is applied in fiber processing, animal fiber, cellulose/protein conjugated artificial filament, etc., can solve the problem of complex hydrogel process, difficult control of drug loading, and drug controllability. , Insufficient release and other problems, to achieve the effect of excellent sustained release function, excellent mechanical properties, and excellent release performance

Inactive Publication Date: 2013-02-20
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of hydrogel is relatively complicated, and the drug loading is not easy to control, and there are still deficiencies in the controllability and release of drugs.

Method used

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  • Drug-loading nano-fiber membrane and preparation method thereof
  • Drug-loading nano-fiber membrane and preparation method thereof
  • Drug-loading nano-fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of spinning solution: ①Weigh 0.4604g of PVA into a dry Erlenmeyer flask, add 4.1mL of deionized water, and stir at 90°C for 2h. ②According to the existing technology, the silk fibroin aqueous solution with a concentration of 6.577% (w / w) is obtained after the natural silk is desericinized, dissolved in a ternary solvent, dialyzed, and centrifuged. ③According to the mass ratio of polyvinyl alcohol and silk fibroin being 7:3, add a certain amount of silk fibroin aqueous solution into the polyvinyl alcohol solution and mix well. ④ Add 0.0494 g of vanillin to the polyvinyl alcohol silk fibroin mixed solution to finally obtain a spinning solution with a vanillin content of 10%.

[0024] (2) Electrospinning: Pour the prepared spinning solution into the glass spinneret, and start applying voltage after the spinning solution flows out of the plastic nozzle. The spinning voltage is 11KV, and the receiving distance between the nozzle and the collecting scree...

Embodiment 2

[0031] (1) Preparation of spinning solution: ①Weigh 0.3946g of PVA into a dry Erlenmeyer flask, add 1.9mL of deionized water, and stir at 90°C for 2h. ② Natural silk is desericinized, dissolved in a ternary solvent, dialyzed and centrifuged to obtain a silk fibroin aqueous solution with a concentration of 6.577% (w / w). ③ Add the silk fibroin aqueous solution (6g) with a mass ratio of polyvinyl alcohol to silk fibroin of 5:5 into the polyvinyl alcohol solution and mix well. ④ Take 0.0524 g of vanillin and add it to the mixed solution of polyvinyl alcohol silk fibroin to finally obtain a polyvinyl alcohol silk fibroin spinning solution with a mass ratio of polyvinyl alcohol to silk fibroin of 5:5 and a vanillin content of 10%.

[0032] (2) Electrospinning: Pour the prepared solution into the glass spinneret, and start applying voltage after the spinning solution flows out of the plastic nozzle. The spinning voltage is 11KV, and the receiving distance is 15cm.

[0033] ...

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Abstract

The invention discloses a drug-loading nano-fiber membrane and a preparation method thereof. The drug-loading nano-fiber membrane comprises 10-20% of vanillin by mass and the balance of polyvinyl alcohol and fibroin; and the ratio of the polyvinyl alcohol to the fibroin is (5-10):(1-5) by mass. According to the invention, the polyvinyl alcohol and fibroin with good biocompatibility are used as a drug carrier, and the polyvinyl alcohol-fibroin drug-loading fiber containing vanillin is prepared by adopting an electrostatic spinning technology; absolute ethyl alcohol is uniformly spread on the surface of the nano-fiber membrane for sufficient reaction; and after drying, a drug-loading nano-fiber membrane is obtained. The preparation technology of the drug-loading nano-fiber membrane is simple; and the obtained material has good biocompatibility and degradability, stable performance and excellent drug releasing performance.

Description

technical field [0001] The invention specifically relates to a vanillin-loaded polyvinyl alcohol silk fibroin nanofiber film and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Polyvinyl alcohol (PVA) is a water-soluble polymer obtained by hydrolysis of polyvinyl acetate, which has good chemical stability and biocompatibility. Polyvinyl alcohol (PVA) is a non-toxic and harmless Polymer with excellent film-forming properties and mechanical properties. Silk fibroin (SF) is a structural protein with simple extraction method and low cost. At the same time, silk fibroin also has the advantages of good compatibility and safety to living tissues, but pure silk fibroin membrane is hard and brittle and easy to break. In wet state or wet state, the mechanical properties of the film are poor. The pure PVA film has poor compatibility with the human body and is not easy to degrade. Therefore, the blending of PVA and SF...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728D01F8/10D01F8/02D01F1/10D06M13/144D06M101/24D06M101/12
Inventor 戴礼兴张豆豆张小雪王一帆孙君王建军
Owner SUZHOU UNIV
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