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Myricetin lipid microcapsule taking lecithin as carrier and preparation method thereof

A technology of myricetin lipid and myricetin, which is applied in the field of myricetin lipid microcapsules and its preparation, can solve the problems of poor stability of plant flavonoids, and achieve the effects of improved stability and outstanding biological activity

Inactive Publication Date: 2013-02-13
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of plant flavonoids is relatively poor. In order to improve its stability, domestic and foreign researchers have carried out research on microcapsules made of cyclodextrin inclusions. The antioxidant stability of plant flavones inclusions by cyclodextrins has been significantly improved.
There are also reports on the use of gelatin and gum arabic as carrier materials to make plant flavonoid microcapsules, but the use of lecithin to make plant flavonoids into lipid microcapsules has not yet been carried out.

Method used

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  • Myricetin lipid microcapsule taking lecithin as carrier and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024] Myricetin (produced by Zhejiang Ningbo Traditional Chinese Medicine Pharmaceutical Co., Ltd., purity 98.0%) weighed 15 g, rapeseed lecithin (purity 60.0%, produced by Zhejiang Quzhou Donggang Oil Factory) weighed 45 g, monoglyceride stearate (food grade, (produced by Guangzhou Yihe Chemical Co., Ltd.) weighed 8 g, completely dissolved the three substances with 10 liters of absolute ethanol, stirred evenly, kept at 60°C under a vacuum of 0.085 MPa, and evaporated to recover ethanol until dry. Add 50 liters of water containing 0.3 g / L Tween 40 (manufactured by Wenzhou Qingming Chemical Co., Ltd.), stir well, and use an 800 W ultrasonic instrument to sonicate the water for 8 minutes to promote the dissolution and dispersion of substances in the water. Stand still for 5 minutes to form myricetin lipid microcapsules. It was determined that the amount of myricetin encapsulated by lipid microcapsules was 92.0% of the raw material, and the particle size of the microcapsules was...

Embodiment 2

[0032] Myricetin (produced by Zhejiang Ningbo Traditional Chinese Medicine Pharmaceutical Co., Ltd., purity 98.0%) weighed 20 g, rapeseed lecithin (purity 70.0%, produced by Zhejiang Quzhou Donggang Oil Factory) weighed 40 g, monoglyceride stearate (food grade, (produced by Guangzhou Yihe Chemical Co., Ltd.) weighed 12 g, completely dissolved the three substances with 15 liters of absolute ethanol, stirred evenly, kept at 70°C under a vacuum of 0.080 MPa, and evaporated to recover ethanol until dry. Add 60 liters of water containing 0.4 g / L Tween 40 (manufactured by Wenzhou Qingming Chemical Co., Ltd.), stir well, and use an ultrasonic instrument with a power of 800 W to sonicate the water for 10 minutes to promote the dissolution and dispersion of substances in the water. After standing still for 10 minutes, myricetin lipid microcapsules are formed. It was determined that the amount of myricetin encapsulated in lipid microcapsules was 91.6% of the raw material, and the partic...

Embodiment 3

[0037] Myricetin (produced by Zhejiang Ningbo Traditional Chinese Medicine Pharmaceutical Co., Ltd., purity 98.0%) weighed 17 g, rapeseed lecithin (purity 55.0%, produced by Zhejiang Quzhou Donggang Oil Factory) weighed 50 g, monoglyceride stearate (food grade, (produced by Guangzhou Yihe Chemical Co., Ltd.) weighed 10 g, completely dissolved the three substances with 13 liters of absolute ethanol, stirred evenly, kept at 50°C under a vacuum of 0.085 MPa, and evaporated to recover ethanol until dry. Add 55 liters of water containing 0.3 g / L Tween 40 (manufactured by Wenzhou Qingming Chemical Co., Ltd.), stir well, and use an ultrasonic instrument with a power of 800 W to sonicate the water for 9 minutes to promote the dissolution and dispersion of substances in the water. Stand still for 8 minutes to form myricetin lipid microcapsules. It was determined that the amount of myricetin encapsulated in lipid microcapsules was 91.3% of the raw material, and the particle size of the ...

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Abstract

The invention provides a myricetin lipid microcapsule taking lecithin as a carrier and a preparation method thereof. The myricetin lipid microcapsule is prepared by the following preparation method: weighing myricetin, rape lecithin or soybean lecithin, and stearic acid monoglyceride in proportion, adding adequate anhydrous ethanol for dissolving, evaporating the obtained solution under the conditions of vacuum degree of 0.080-0.085 MPa and temperature of 50-70 EDG C to recover ethanol to be dry, adding adequate tween 40 aqueous solution with the concentration of 0.3-0.4g / L into a residual material, fully dissolving under the ultrasonic condition, and standing for 5-10 minutes after completely dissolving to prepare the myricetin lipid microcapsule. The preparation method utilizes the lecithin of the vegetable oil materials for preparing the myricetin into the lipid microcapsule, with the particle size controlled to be 100nm-300nm; and the stability of the prepared plant flavonoid lipid microcapsule is obviously improved compared with flavonoid powder, especially the in vivo bioavailability is increased. Animal studies show that the absorption rate of the lipid microcapsule is increased by more than 2 times compared with original powder so as to more prominently give play to the biological activities of the plant flavonoid.

Description

(1) Technical field [0001] The invention relates to a myricetin lipid microcapsule with lecithin as a carrier and a preparation method thereof. (2) Background technology [0002] A variety of plant flavonoids have biological activities such as lowering blood fat, regulating blood sugar, enhancing cardiovascular function, and anti-oxidation, and are widely used as raw materials for medicines and health foods. However, the stability of plant flavonoids is relatively poor. In order to improve its stability, domestic and foreign researchers have carried out research on microcapsules made of cyclodextrin inclusions. There are also reports of using gelatin and gum arabic as carrier materials to make plant flavonoid microcapsules, but using lecithin to make plant flavonoids into lipid microcapsules has not yet been carried out. (3) Contents of the invention [0003] The biological activity of plant flavonoids is more prominent, and a variety of plant flavonoids are made into med...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/352A61K47/24A61P3/06A61P3/08A61P9/00A61P39/06A23L1/29A23L33/00
Inventor 钱俊青郭辉竺少铭
Owner ZHEJIANG UNIV OF TECH
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