Hollow fibrous membrane with cell membrane simulation structure and construction method thereof

A technology of imitating cell membrane and construction method, which is applied in the field of hollow fiber membrane imitating cell membrane structure and its construction, can solve the problems of unstable coating, complex chemical reaction fixing coating process, unsatisfactory modification effect, etc., and achieve good biophase Capacitance, Surface Hydrophilicity and Biocompatibility Improvement, Stability Enhancement Effect

Inactive Publication Date: 2013-01-23
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a method for constructing a stable imitation cell outer layer membrane structure coating on the hollow fiber membrane surface, to overcome the instability of the usual physical adsorption polymer coating, the complexity of the chemical reaction fixing coating process, and the improvement Unsatisfactory sexual effect

Method used

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  • Hollow fibrous membrane with cell membrane simulation structure and construction method thereof
  • Hollow fibrous membrane with cell membrane simulation structure and construction method thereof
  • Hollow fibrous membrane with cell membrane simulation structure and construction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 1.2 g of methacryloxypropyltrimethoxysilane (MPS) monomer and 2.8 g of n-butyl methacrylate (BMA) monomer and dissolve them in 80 ml of absolute ethanol in a 250 ml three-necked bottle. 3.6 g of methacryloyloxyethoxyphosphorylcholine (MPC) and 0.050 g of initiator AIBN were respectively dissolved in 40 ml of absolute ethanol. After 30 minutes of deoxygenation by nitrogen gas, 30% of the MPC solution and the AIBN solution were simultaneously added at 60° C., and the remaining part was added dropwise within 2 hours. It was then condensed under reflux at 65°C and stirred for 16 hours. The product was precipitated with ether, rinsed, washed with acetonitrile, and dried with 1 The molar content of each component of MPC, BMA and MPS measured by H nuclear magnetic resonance spectrum is 40%, 42% and 18%, and the terpolymer is marked as PMBT442.

Embodiment 2

[0029] Take 0.95 g of methacryloxypropyltrimethoxysilane (MPS) monomer and 1.2 g of lauryl methacrylate (LMA) monomer and dissolve them in 60 ml of anhydrous isopropanol in a 250 ml three-necked bottle middle. Dissolve 1.8 g of methacryloyloxyethoxyphosphorylcholine (MPC) and 0.040 g of initiator AIBN in 40 ml of absolute ethanol. After passing through nitrogen to remove oxygen for 30 minutes, add 30% of the MPC and AIBN solution at 80° C., and the rest is added dropwise within 2 hours. It was then reflux condensed at 80°C and stirred for 16 hours. The product was precipitated with ether, rinsed, washed with acetonitrile, and dried with 1 The molar content of each component of MPC, BMA and MPS measured by H nuclear magnetic resonance spectrum is 52%, 31% and 17%, and the terpolymer is marked as PMLT532.

Embodiment 3

[0031] PMBT442 was formulated into a 1.0 mg / ml methanol solution, and the polypropylene hollow fiber membrane was immersed in the solution, taken out after 20 seconds and dried in a fume hood to form a coating. The coating was treated in 10% triethylamine aqueous vapor at room temperature for 3 days to obtain a cross-linked and stable coating. The advancing angle in contact with water is 80 degrees, and the receding angle is 60 degrees. Compared with the uncoated modified polypropylene fiber, the advancing angle is reduced by 20 degrees, and the receding angle is reduced by 40 degrees, such as figure 1 shown. After the coating was soaked in ethanol and 2% sodium dodecylsulfonate aqueous solution, the contact angle did not increase significantly, which proved that the coating had good stability. X-ray photoelectron spectroscopy shows that N, P, and Si elements in the polymer appear on the surface of the modified fiber, which proves that the polymer exists stably on the fiber ...

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Abstract

The invention discloses a hollow fibrous membrane with a cell membrane simulation structure and a construction method thereof. The method comprises the following steps of: dissolving a terpolymer containing a trimethoxy silicon crosslinkable group, a hydrophilic group and hydrophobic alkyl into an organic solvent; forming a coating on the surface of a hollow fibrous membrane with a spraying or dipping method; and treating the coating in aqueous solution steam of triethylamine, trimethylamine or ammonia for 2-5 days to form a stably-crosslinked cell membrane simulation structural coating. The hollow fibrous membrane used in the invention is a micropore fibrous membrane, so that the surface area of the hollow fibrous membrane is increased, and adsorption of stabilization of a polymer coating are facilitated; and crosslinking fixation is performed on the polymer on the surface of a hollow fibrous membrane material after coating, so that the stability of the coating can be enhanced remarkably, and high hydrophilicity and high biocompatibility are achieved.

Description

technical field [0001] The invention relates to a hollow fiber membrane imitating a cell membrane structure and a construction method thereof, in particular to a method for constructing a hollow fiber membrane imitating a cell membrane structure by using a cross-linkable amphiphilic (meth)acrylate copolymer on the surface of the hollow fiber membrane, belonging to Polymer chemistry and physics, surface science and biomedical materials technology. Background technique [0002] Hollow fiber membranes are the core components of medical devices such as artificial kidneys and artificial lungs. They are usually made of polysulfone, polyacrylonitrile, polypropylene, polyvinylidene fluoride, cellulose acetate, polyvinyl chloride, polyvinyl alcohol, poly The processing and preparation of amide hollow fiber membranes are used for auxiliary treatment such as hemodialysis, blood purification, ultrafiltration concentration and reinfusion of liver ascites. During use, the surface of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/38B01D67/00B01D69/08B01D69/02
Inventor 宫永宽王彦兵
Owner NORTHWEST UNIV(CN)
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