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Efficient florfenicol powder composition and preparation method thereof

A technology of florfenicol and composition, which is applied in the field of high-efficiency florfenicol powder composition and its preparation, can solve the problems of unsatisfactory expected results and low solubility of florfenicol, achieve simple preparation method, improve antibacterial effect of effect

Inactive Publication Date: 2013-01-23
上海明磊邦森生物科技(登封)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are also scholars who have carried out research on florfenicol superfine powder in order to improve the dissolution rate of florfenicol (Nanjing Agricultural University, Wang Jiacai's master's thesis), but the expected results are not ideal. Low problem, preparation of florfenicol-β-cyclodextrin inclusion compound (Wei Xiaozang, Zhongnan Pharmacy, 2006, December)

Method used

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  • Efficient florfenicol powder composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 500 g of florfenicol, dissolve it with 3000 mL of acetone, and set aside.

[0035] In addition, take 5 kg of florfenicol adsorption material lactose, dissolve it in 50 liters of water, then add 27 g of disodium salt of ethylenediaminetetraacetic acid, and dissolve 55 g of sodium lauryl sulfate; add the acetone solution of florfenicol to the above-mentioned In the solution containing lactose, stir quickly and spray quickly (spray conditions: the air inlet temperature is controlled at 150-180°C, the air outlet temperature is controlled at 40-50°C, the spray pressure is 0.5-0.6 Mpa, and the vacuum degree is controlled at 0-20 between Kpa), collect the product and dry it at 60-70°C for 5 hours to obtain the product.

[0036] The product obtained is released in vitro according to conventional methods, compared with the florfenicol raw material drug, with water as the release medium, the HPLC method is used to measure the drug content, and the release percentage at each...

Embodiment 2

[0039] Weigh and take Florfenicol 100g, dissolve it with 5000mL of ethanol, and set aside.

[0040] In addition, take by weighing 5 kg of the porous micropowder silica gel of Florfenicol adsorption material, disperse with 50 liters of water, add EDTA disodium salt 10 g, sodium lauryl sulfate 50 g and dissolve; the ethanol solution of Florfenicol Add it into the suspension containing porous micro-powdered silica gel, stir quickly, and spray quickly (spray conditions: the air inlet temperature is controlled at 150-180°C, the air outlet temperature is controlled at 40-50°C, the spray pressure is 0.5-0.6 Mpa, the control The vacuum degree is between 0-20 Kpa), and the product is collected and dried at 60-70°C for 5 hours to obtain the product.

[0041] The product obtained is released in vitro according to conventional methods, compared with the florfenicol raw material drug, with water as the release medium, the HPLC method is used to measure the drug content, and the release perce...

Embodiment 3

[0044] Weigh and take Florfenicol 250g, dissolve with ethyl acetate 5000mL, set aside.

[0045] In addition, take by weighing 5 kg of florfenicol adsorption material cornstarch glue, disperse with 50 liters of water, add 55 g of disodium salt of edetate, and dissolve 10 g of sodium lauryl sulfate; the ethyl acetate of florfenicol Add the solution into the suspension containing cornstarch, stir quickly, and spray quickly (spray conditions: the air inlet temperature is controlled at 150-180°C, the air outlet temperature is controlled at 40-50°C, the spray pressure is 0.5-0.6 Mpa, and the vacuum is controlled The temperature is between 0 and 20 Kpa), and the product is collected and dried at 60 to 70°C for 5 hours to obtain the product.

[0046] The product obtained is released in vitro according to conventional methods, compared with the florfenicol raw material drug, with water as the release medium, the HPLC method is used to measure the drug content, and the release perce...

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Abstract

The invention discloses an efficient florfenicol powder composition and a preparation method thereof. The powder composition comprises the following components in percentage by weight: 1-50% of florfenicol, 46-98.9% of a florfenicol-absorbed carrier and 0.05-4% of a florfenicol absorption promoter. The method comprises the following steps of: preparing the raw materials according to the above components; preparing a florfenicol organic solvent solution; dissolving the florfenicol absorption promoter and the florfenicol-absorbed carrier into water to obtain a mixed water solution; and adding the florfenicol organic solvent solution into the mixed water solution, and rapidly spray-drying. The preparation method disclosed by the invention is simple and low in cost. The product disclosed by the invention has the advantages of extrinsic quick release, esoteric quick absorption, high plasma peak concentration, thorough drug absorption and less antibiotic residue. The product disclosed by the invention can be applied to the treatment of infection on all parts of domestic animals caused by bacteria.

Description

technical field [0001] The invention relates to an antibacterial drug for animals and a preparation method thereof, in particular to a high-efficiency florfenicol powder composition and a preparation method thereof. Background technique [0002] Florfenicol (florfenicol), also known as fluprofen, is a monofluorinated derivative of thiamphenicol, chemical name: (R-(R*,R*))-dichloro-N-(1-(fluoro Methyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide. Florfenicol is the third-generation product of chloramphenicol, which is a new broad-spectrum antibiotic for animals. Florfenicol was launched in Japan in 1990, in Norway in 1993, in France, the United Kingdom, Audrey and Spain in 1995, and was also approved in China. The 2010 edition (Chinese Veterinary Pharmacopoeia) has been accepted. Powders, injections, etc. containing florfenicol. However, different preparations of florfenicol have different dosage forms in use, and there are significant differences in efficacy in...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/165A61K47/38A61K47/36A61K47/26A61K47/02A61K47/18A61P31/04
Inventor 张正全
Owner 上海明磊邦森生物科技(登封)有限公司
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