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Application of anisodine hydrobromide in preparing medicines for treating depression

A technology for anisodine hydrobromide and depression, which is applied in the field of medicine and can solve the problems of cognitive impairment of patients, large individual differences in medicines, and poor medication compliance.

Inactive Publication Date: 2012-12-12
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still adverse reactions such as anxiety, agitation, sexual dysfunction and nausea
Moreover, these drugs vary greatly among individuals, and some medication compliance is poor
And these drugs have different degrees of damage to the cognitive function of patients

Method used

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  • Application of anisodine hydrobromide in preparing medicines for treating depression
  • Application of anisodine hydrobromide in preparing medicines for treating depression
  • Application of anisodine hydrobromide in preparing medicines for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0016] Embodiment: Therapeutic effect of anisodine hydrobromide on depression model rats

[0017] 1. Experimental plan

[0018] 1. Experimental animals: 60 SD rats, purchased from the Experimental Animal Center of Zhengzhou University, clean grade, 200-250 g body weight, animal and feed certificate: SCXK (Yu) 2005-0001.

[0019] 2. After the animals are purchased, there are 6-7 animals per cage, room temperature 18-22°C, regular ventilation, placed under natural circadian rhythm lighting conditions, controlling interfering sound and light, providing sufficient drinking water (sterilized water) and standard mouse feed, Free to eat and drink. Feed for 1 week to adapt to the environment, touch and grasp the rats one by one every day to adapt to the operation and light of the experimenter.

[0020] 3. After the rats have adapted to the environment, measure their autonomous behavior, remove those with high and low behavior scores, select 30 rats, weigh them, and divide them into ...

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Abstract

The invention discloses application of anisodine hydrobromide in preparing medicines for preventing or treating depression, in order to develop a medicine for effectively preventing or treating depression. Anisodine has the chemical formula of C17H21NO5 and a relative molecular weight of 319.35, is a pyrethroid type alkaloid, is present in belladonna plants and is a choline receptor blocking agent isolated firstly in China. The hydrobromide of the anisodine is mainly used clinically, and can be used for treating vascular headache, retinal vasospasm, central retinopathy, ischemic optic neuropathy, acute paralysis, paralysis agitans, bronchial asthma, kinesia, organic phosphorus pesticide poisoning and the like. However, literatures reporting treatment of depression are not available. In the invention, experiments show that anisodine hydrobromide plays a role in treating depression, and has a very good therapeutic effect in depression symptoms of interest blank, pleasant sensation disappearance, reduced exiting degree, reduced increment of body weight and the like.

Description

technical field [0001] The invention relates to a new application of anisodine hydrobromide, in particular to the application in the preparation of drugs for treating depression, and belongs to the technical field of medicine. Background technique [0002] Depression is a common mood disorder in psychiatry, with significant and persistent low mood or loss of interest as the core symptom, often accompanied by excessive worry, sleep disturbance, low self-evaluation, social avoidance, and the patient feels extremely painful subjectively. Depression is characterized by high rates of suicide, self-harm, and relapse. It is estimated that the number of patients with major depressive disorder in my country has reached 26 million, and depression ranks second in the burden of disease in developed countries. Systemic diseases and malignant tumors. At present, the average incidence of depression is about 2%, and the lifetime prevalence of depression is about 17%, and most cases have re...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P25/24
Inventor 吕路线李文强赵晶媛杨鸽张红星杨勇锋王秀娟丁敏利
Owner XINXIANG MEDICAL UNIV
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